Search Results - "Samadfam, R"

Effects of long term treatment with high doses of odanacatib on bone mass, bone strength, and remodeling/modeling in newly ovariectomized monkeys by Duong, L.T, Pickarski, M, Cusick, T, Chen, C.M, Zhuo, Y, Scott, K, Samadfam, R, Smith, S.Y, Pennypacker, B.L

“…Abstract The objectives here were to evaluate the effects of odanacatib (ODN) at doses exceeding the clinical exposure on biomechanical properties of lumbar…”
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Differential effects of odanacatib and alendronate on bone turnover in the femoral neck of adult ovariectomized rhesus monkeys by Cusick, T.T, Pennypacker, B, Pickarski, M, Samadfam, R, Duong, L.T

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Effect of ovx on body composition, insulin and lipid profile by Samadfam, R, Awori, M, Wright, M, Smith, S.Y

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Effects of odanacatib compared to alendronate on bone remodeling and biomechanical properties of the lumbar spine in estrogen-deficient rhesus monkeys by Pennypacker, B, Chen, C.M, Zhuo, Y, Scott, K.R, Pickarski, M, Samadfam, R, Duong, L.T

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Combined activation of PPAR-gamma and PPAR-alpha reduces the negative effects of PPAR-gamma agonism on bone and may attenuate PPAR-gamma-mediated loss of bone strength by Smith, S, Samadfam, R, Chouinard, L, Awori, M, Benardeau, A, Bauss, F, Sebokova, E, Wright, M.B

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ALX-0141, an anti-rank-L targeting nanobody®, increases bone mass in cynomolgus monkeys by Samadfam, R, Jacobs, S, Van Roy, M, McGuire, A, Schoen, P, Baumeister, J, Smith, S.Y, Holz, J.-B

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580 Validation of an atopic dermatitis model in mice by repeated intra-dermal challenges with ovalbumin by Rashid, H., Samadfam, R.

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Further reductions in bone turnover after transition from alendronate to denosumab in ovariectomized cynomolgus monkeys resulted in maintained or improved cortical and trabecular bone mass and bone strength by Ominsky, M.S, Smith, S.Y, Jolette, J, Vlasseros, F, Samadfam, R, Kostenuik, P.J

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Contribution of B2 receptors for bradykinin in Arthus reaction‐induced plasma extravasation in wild‐type or B2 transgenic knockout mice by Samadfam, R, Teixeira, C, Bkaily, G, Sirois, P, De Brum‐Fernandes, A, D'Orleans‐Juste, P

“…The aim of the present study was to investigate the contribution of bradykinin (BK) B1 and B2 receptors in a model of type III hypersensitivity, the reverse…”
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Highly Predictive Objective Measurement of OA Joint Pain in Rat Using Bioseb Automated Dynamic Weight Bearing System by Rashid, Harun, Cornicelli, Joe, Young, Alan, Samadfam, Rana

“…Abstract only…”
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Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys by Masarachia, Patricia J, Pennypacker, Brenda L, Pickarski, Maureen, Scott, Kevin R, Wesolowski, Gregg A, Smith, Susan Y, Samadfam, Rani, Goetzmann, Jason E, Scott, Boyd B, Kimmel, Donald B, Duong, Le T

“…Odanacatib (ODN) is a selective and reversible inhibitor of cathepsin K (CatK) currently being developed as a once‐weekly treatment for osteoporosis. In this…”
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Effects of Denosumab, Alendronate, or Denosumab Following Alendronate on Bone Turnover, Calcium Homeostasis, Bone Mass and Bone Strength in Ovariectomized Cynomolgus Monkeys by Kostenuik, Paul J, Smith, Susan Y, Samadfam, Rana, Jolette, Jacquelin, Zhou, Lei, Ominsky, Michael S

“…ABSTRACT Postmenopausal osteoporosis is a chronic disease wherein increased bone remodeling reduces bone mass and bone strength. Antiresorptive agents…”
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Co‐Treatment of PTH With Osteoprotegerin or Alendronate Increases Its Anabolic Effect on the Skeleton of Oophorectomized Mice by Samadfam, Rana, Xia, Qingwen, Goltzman, David

“…We examined the effects of 60 days of co‐treatment of PTH with either OPG or alendronate in oophorectomized mice. Compared with PTH alone, co‐treatment of PTH…”
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Cathepsin K inhibitors prevent bone loss in estrogen‐deficient rabbits by Pennypacker, Brenda L, Duong, Le T, Cusick, Tara E, Masarachia, Patricia J, Gentile, Michael A, Gauthier, Jacques‐Yves, Black, W Cameron, Scott, Boyd B, Samadfam, Rana, Smith, Susan Y, Kimmel, Donald B

“…Two cathepsin K inhibitors (CatKIs) were compared with alendronate (ALN) for their effects on bone resorption and formation in ovariectomized (OVX) rabbits…”
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The Effect of Rosiglitazone on Bone Mass and Fragility Is Reversible and Can Be Attenuated With Alendronate by Kumar, Sanjay, Hoffman, Sandra J, Samadfam, Rana, Mansell, Peter, Jolette, Jacquelin, Smith, Susan Y, Guldberg, Robert E, Fitzpatrick, Lorraine A

“…ABSTRACT Rosiglitazone (RSG) is an antidiabetic drug that has been associated with increased peripheral fractures, primarily in postmenopausal women. In this…”
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The calcium‐sensing receptor and 25‐hydroxyvitamin D–1α‐hydroxylase interact to modulate skeletal growth and bone turnover by Richard, Christian, Huo, Rujuan, Samadfam, Rana, Bolivar, Isabel, Miao, Dengshun, Brown, Edward M, Hendy, Geoffrey N, Goltzman, David

“…We examined parathyroid and skeletal function in 3‐month‐old mice expressing the null mutation for 25‐hydroxyvitamin D–1α‐hydroxylase [1α(OH)ase−/−] and in…”
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Contribution of B 2 receptors for bradykinin in Arthus reaction‐induced plasma extravasation in wild‐type or B 2 transgenic knockout mice by Samadfam, R, Teixeira, C, Bkaily, G, Sirois, P, De Brum‐Fernandes, A, D'Orleans‐Juste, P

“…The aim of the present study was to investigate the contribution of bradykinin (BK) B 1 and B 2 receptors in a model of type III hypersensitivity, the reverse…”
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Production of Prostaglandin D2 by Human Osteoblasts and Modulation of Osteoprotegerin, RANKL, and Cellular Migration by DP and CRTH2 Receptors by Gallant, Maxime A, Samadfam, Rana, Hackett, Josette A, Antoniou, John, Parent, Jean‐Luc, de Brum‐Fernandes, Artur J

“…Human osteoblasts produce PGD2, which acts on the DP receptor to decrease osteoprotegerin production and on the CRTH2 receptor to decrease RANKL expression and…”
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Exogenous PTH and Endogenous 1,25‐Dihydroxyvitamin D Are Complementary in Inducing an Anabolic Effect on Bone by Samadfam, Rana, Xia, Qingwen, Miao, Dengshun, Hendy, Geoffrey N, Goltzman, David

“…PTH and 1,25(OH)2D each exert dual anabolic and catabolic skeletal effects. We assessed the potential interaction of PTH and 1,25(OH)2D in promoting skeletal…”
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Assessing postnatal skeletal development in non-clinical reproductive toxicology and pediatric studies by Adamo, Maria, Pouliot, Louise, Barbeau, Stephanie, Samadfam, R., Varela, A., Primakova, I., Smith, Susan Y., Robinson, Keith

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