Search Results - "Salviano, Ísis"
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Targeting Cellular Signaling Pathways in Breast Cancer Stem Cells and its Implication for Cancer Treatment
Published in Anticancer research (01-11-2016)“…Breast cancer is a public health problem both in developing and developed countries. The breast cancer stem cell (BCSC) hypothesis has grown in the cancer…”
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The tumor suppressor role of salvador family WW domain-containing protein 1 (SAV1): one of the key pieces of the tumor puzzle
Published in Journal of cancer research and clinical oncology (01-05-2021)“…Purpose In the complex tumor scenario, understanding the function of proteins with protumor or antitumor roles is essential to support advances in the cancer…”
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The APE1/REF-1 and the hallmarks of cancer
Published in Molecular biology reports (01-12-2024)“…APE1/REF-1 (apurinic/apyrimidinic endonuclease 1 / redox factor-1) is a protein with two domains, with endonuclease function and redox activity. Its main…”
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Regulation Is in the Air: The Relationship between Hypoxia and Epigenetics in Cancer
Published in Cells (Basel, Switzerland) (01-04-2019)“…Hypoxia is an inherent condition of tumors and contributes to cancer development and progression. Hypoxia-inducible factors (HIFs) are the major transcription…”
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APX2009 sensitizes hypoxic breast cancer cells to doxorubicin by increasing its accumulation and caspase-3/7-mediated apoptosis
Published in Breast cancer research and treatment (13-10-2024)“…The association of targeted therapy with chemotherapy is encouraged to increase the treatment efficiency, especially in hypoxic triple-negative breast cancer…”
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Mitochondria in colorectal cancer stem cells - a target in drug resistance
Published in Cancer drug resistance (01-01-2023)“…Colorectal cancer (CRC) is the third most diagnosed cancer and the second most deadly type of cancer worldwide. In late diagnosis, CRC can resist therapy…”
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Profiles of Expression of SAV1 in Normoxia or Hypoxia Microenviroment are Associated with Breast Cancer Prognosis
Published in Archives of medical research (01-02-2023)“…In breast cancer (BC), hypoxia is associated with poor prognosis. Protein Salvador homolog 1 (SAV1) acts as a tumor suppressor and is downregulated in the…”
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Neonatal overfeeding impairs differentiation potential of mice subcutaneous adipose mesenchymal stem cells
Published in Stem cell reviews (01-08-2018)“…Nutritional changes in the development (intrauterine life and postnatal period) may trigger long-term pathophysiological complications such as obesity and…”
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Opposite effects of demethylating treatment on VEGFA and HIF1A expression in MDA-MB-231 breast cancer cell line in hypoxic microenvironment
Published in Gene reports (01-09-2019)Get full text
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5-Aza-2’-deoxycytidine induces a greater inflammatory change, at the molecular levels, in normoxic than hypoxic tumor microenvironment
Published in Molecular biology reports (01-02-2021)“…Hypoxia is associated with tumor aggressiveness and poor prognosis, including breast cancer. Low oxygen levels induces global genomic hypomethylation and…”
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Transcriptome analysis of breast cancer cell line exposed to hypoxia-mimetic chemical CoCl2 or hypoxic microenvironment
Published in Gene reports (01-09-2020)“…Hypoxia is a common feature of solid tumors, including breast cancer, and is related to aggressiveness and poor prognosis. The hypoxia-inducible factor 1,…”
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High‐Resolution Melting (HRM) of Hypervariable Mitochondrial DNA Regions for Forensic Science
Published in Journal of forensic sciences (01-03-2018)“…Forensic strategies commonly are proceeding by analysis of short tandem repeats (STRs); however, new additional strategies have been proposed for forensic…”
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STAT3 Regulates the Redox Profile in MDA-MB-231 Breast Cancer Cells
Published in Cell biochemistry and biophysics (01-12-2024)“…Unbalanced redox status and constitutive STAT3 activation are related to several aspects of tumor biology and poor prognosis, including metastasis and drug…”
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The orally active pterocarpanquinone LQB‐118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress
Published in The Prostate (01-02-2018)“…Background The targeted induction of reactive oxygen species (ROS) is a developing mechanism for cancer therapy. LQB‐118 is a pterocarpanquinone and…”
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Preservação arquitetônica: teoria, legislação e prática
Published in Revista CPC (11-04-2013)Get full text
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