Search Results - "Salvesen, G S"

Regulation of Cell Death Protease Caspase-9 by Phosphorylation by Cardone, Michael H., Roy, Natalie, Stennicke, Henning R., Salvesen, Guy S., Franke, Thomas F., Stanbridge, Eric, Frisch, Steven, Reed, John C.

“…Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced…”
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Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC by Snipas, S J, Drag, M, Stennicke, H R, Salvesen, G S

“…Drosophila Nedd2-like caspase (DRONC), an initiator caspase in Drosophila melanogaster and ortholog of human caspase-9, is cleaved during its activation in…”
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X-linked IAP is a direct inhibitor of cell-death proteases by Reed, John C, Deveraux, Quinn L, Takahashi, Ryosuke, Salvesen, Guy S

“…The inhibitor-of-apoptosis (IAP) family of genes has an evolutionarily conserved role in regulating programmed cell death in animals ranging from insects to…”
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Dimer Formation Drives the Activation of the Cell Death Protease Caspase 9 by Renatus, Martin, Stennicke, Henning R., Scott, Fiona L., Liddington, Robert C., Salvesen, Guy S.

“…A critical step in the induction of apoptosis is the activation of the apoptotic initiator caspase 9. We show that at its normal physiological concentration,…”
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Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8 by Stennicke, H R, Renatus, M, Meldal, M, Salvesen, G S

“…Subsite interactions are considered to define the stringent specificity of proteases for their natural substrates. To probe this issue in the proteolytic…”
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Caspase substrates by Timmer, J C, Salvesen, G S

“…The relatively common occurrence of sequences within proteins that match the consensus substrate specificity of caspases in intracellular proteins suggests a…”
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Apolipoprotein E: High-Avidity Binding to β-Amyloid and Increased Frequency of Type 4 Allele in Late-Onset Familial Alzheimer Disease by Strittmatter, Warren J., Saunders, Ann M., Schmechel, Donald, Pericak-Vance, Margaret, Enghild, Jan, Salvesen, Guy S., Roses, Allen D.

“…Apolipoprotein E is immunochemically localized to the senile plaques, vascular amyloid, and neurofibrillary tangles of Alzheimer disease. In vitro,…”
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Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways by McStay, G P, Salvesen, G S, Green, D R

“…Caspases orchestrate the controlled demise of a cell after an apoptotic signal through specific protease activity and cleavage of many substrates altering…”
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Binding of Human Apolipoprotein E to Synthetic Amyloid β Peptide: Isoform-Specific Effects and Implications for Late-Onset Alzheimer Disease by Strittmatter, Warren J., Weisgraber, Karl H., Huang, David Y., Dong, Li-Ming, Salvesen, Guy S., Pericak-Vance, Margaret, Schmechel, Donald, Saunders, Ann M., Goldgaber, Dmitry, Roses, Allen D.

“…Apolipoprotein E (apoE), a plasma apolipoprotein that plays a central role in lipoprotein metabolism, is localized in the senile plaques, congophilic…”
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Catalytic properties of the caspases by Stennicke, H R, Salvesen, G S

“…Caspase stands for cysteine-dependent aspartate specific protease, and is a term coined to define proteases related to interleukin 1beta converting enzyme and…”
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The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis by Bredesen, Dale E, Mehlen, Patrick, Rabizadeh, Shahrooz, Snipas, Scott J, Assa-Munt, Nuria, Salvesen, Guy S

“…The development of colonic carcinoma is associated with the mutation of a specific set of genes. One of these, DCC (deleted in colorectal cancer), is a…”
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Dying from within: granzyme B converts entosis to emperitosis by Salvesen, G S

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Endogenous inhibitors of caspases by DEVERAUX, Q. L, STENNICKE, H. R, SALVESEN, G. S, REED, J. C

“…Caspases are cysteine proteases that are specific for aspastic acid residues. These enzymes have been extensively characterized as integral and highly…”
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Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates by Poreba, M, Kasperkiewicz, P, Snipas, S J, Fasci, D, Salvesen, G S, Drag, M

“…Traditional combinatorial peptidyl substrate library approaches generally utilize natural amino acids, limiting the usefulness of this tool in generating…”
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Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling by Chou, James J, Li, Honglin, Salvesen, Guy S, Yuan, Junying, Wagner, Gerhard

“…We report the solution structure of BID, an intracellular cross-talk agent that can amplify FAS/TNF apoptotic signal through the mitochondria death pathway…”
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Metacaspases are not caspases - always doubt by Enoksson, M, Salvesen, G S

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A lysosomal protease enters the death scene by Salvesen, G S

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Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6 by van Raam, B J, Ehrnhoefer, D E, Hayden, M R, Salvesen, G S

“…Necroptosis is a form of programmed cell death that occurs in the absence of caspase activation and depends on the activity of the receptor-interacting protein…”
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Kennedy's disease : Caspase cleavage of the androgen receptor is a crucial event in cytotoxicity by ELLERBY, L. M, HACKAM, A. S, HAYDEN, M. R, BREDESEN, D. E, PROPP, S. S, ELLERBY, H. M, RABIZADEH, S, CASHMAN, N. R, TRIFIRO, M. A, PINSKY, L, WELLINGTON, C. L, SALVESEN, G. S

“…X-linked spinal and bulbar muscular atrophy (SBMA), Kennedy's disease, is a degenerative disease of the motor neurons that is associated with an increase in…”
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Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion by Leverrier, S, Salvesen, G S, Walsh, C M

“…The extrinsic, or death receptor, pathway integrates apoptotic signals through the protease caspase-8 (casp8). Beyond cell death regulation, non-apoptotic…”
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