Search Results - "Salvaris, E. J."

Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in Baboons by Hawthorne, W. J., Salvaris, E. J., Phillips, P., Hawkes, J., Liuwantara, D., Burns, H., Barlow, H., Stewart, A. B., Peirce, S. B., Hu, M., Lew, A. M., Robson, S. C., Nottle, M. B., D'Apice, A. J. F., O'Connell, P. J., Cowan, P. J.

“…The instant blood‐mediated inflammatory reaction (IBMIR) is a major obstacle to the engraftment of intraportal pig islet xenografts in primates. Higher…”
Get full text

Pig Thrombomodulin Binds Human Thrombin but Is a Poor Cofactor for Activation of Human Protein C and TAFI by Roussel, J. C., Moran, C. J., Salvaris, E. J., Nandurkar, H. H., D'Apice, A. J. F., Cowan, P. J.

“…Incompatibility between pig thrombomodulin (TM) and primate thrombin is thought to be an important factor in the development of microvascular thrombosis in…”
Get full text

Protective Effects of Transgenic Human Endothelial Protein C Receptor Expression in Murine Models of Transplantation by Lee, K. F. E., Lu, B., Roussel, J. C., Murray‐Segal, L. J., Salvaris, E. J., Hodgkinson, S. J., Hall, B. M., d'Apice, A. J. F., Cowan, P. J., Gock, H.

“…Thrombosis and inflammation are major obstacles to successful pig‐to‐human solid organ xenotransplantation. A potential solution is genetic modification of the…”
Get full text

Bortezomib, C1‐Inhibitor and Plasma Exchange Do Not Prolong the Survival of Multi‐Transgenic GalT‐KO Pig Kidney Xenografts in Baboons by Le Bas‐Bernardet, S., Tillou, X., Branchereau, J., Dilek, N., Poirier, N., Châtelais, M., Charreau, B., Minault, D., Hervouet, J., Renaudin, K., Crossan, C., Scobie, L., Takeuchi, Y., Diswall, M., Breimer, M. E., Klar, N., Daha, M. R., Simioni, P., Robson, S. C., Nottle, M. B., Salvaris, E. J., Cowan, P. J., d'Apice, A. J. F., Sachs, D. H., Yamada, K., Lagutina, I., Duchi, R., Perota, A., Lazzari, G., Galli, C., Cozzi, E., Soulillou, J.‐P., Vanhove, B., Blancho, G.

“…Galactosyl‐transferase KO (GalT‐KO) pigs represent a potential solution to xenograft rejection, particularly in the context of additional genetic…”
Get full text

Human Endothelial Protein C Receptor Overexpression Protects Intraportal Islet Grafts in Mice by Gock, H, Lee, K.F.E, Murray-Segal, L, Mysore, T.B, d'Apice, A.J.F, Salvaris, E.J, Cowan, P.J

“…Abstract Islet transplantation can potentially cure type 1 diabetes mellitus, but it is limited by a shortage of human donors as well as by islet graft…”
Get full text

Transgenic expression of human alpha 1,2-fucosyltransferase (H-transferase) prolongs mouse heart survival in an ex vivo model of xenograft rejection by Chen, Chao-Guang, Salvaris, E J, Romanella, M, Aminian, A, Katerelos, M, Fisicaro, N, D'Apice, AJF, Pearse, MJ

“…The expression of human alpha 1,2-fucosyltransferase (H-transferase, HT) has been proposed as an alternative strategy to alpha 1,3-galactosyltransferase (GT)…”
Get full text

Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft Function by MYSORE, Tharun B, SHINKEL, Trixie A, CHANDRA, Abhilash P, O'CONNELL, Philip J, D'APICE, Anthony J. F, COWAN, Peter J, COLLINS, James, SALVARIS, Evelyn J, FISICARO, Nella, MURRAY-SEGAL, Lisa J, JOHNSON, Lucinda E. A, LEPORE, Diana A, WALTERS, Stacey N, STOKES, Rebecca

“…Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft…”
Get full text

Rhesus monkeys and baboons develop FVIII inhibitors in response to porcine endothelial cells or islets by Stewart, JM, Tarantal, AF, Hawthorne, WJ, Salvaris, EJ, O’Connell, PJ, Nottle, MB, d’Apice, AJF, Cowan, PJ, Kearns-Jonker, M

Get full text

Xenoantibody Response to Porcine Islet Cell Transplantation using GTKO, CD55, CD59, and Fucosyl-Transferase Multiple Transgenic Donors by Chen, Y, Stewart, JM, Gunthart, M, Hawthorne, WJ, Salvaris, EJ, O’Connell, PJ, Nottle, MB, d’Apice, AJF, Cowan, PJ, Kearns-Jonker, M

Get full text

Transgenic expression of human α1,2-fucosyltransferase (H-transferase) prolongs mouse heart survival in an ex vivo model of xenograft rejection by CHEN, C.-G, SALVARIS, E. J, ROMANELLA, M, AMINIAN, A, KATERELOS, M, FISICARO, N, D'APICE, A. J. F, PEARSE, M. J

Get full text

Recombinant pig TFPI efficiently regulates human tissue factor pathways by Lee, K. F. Eddy, Salvaris, Evelyn J., Roussel, Jean-Christian, Robson, Simon C., D'Apice, Anthony J. F., Cowan, Peter J.

“…:  Rejected pig‐to‐primate organ xenografts almost invariably exhibit significant microvascular thrombosis, believed to be due in part to several molecular…”
Get full text

Transgenic expression of human alpha1,2-fucosyltransferase (H-transferase) prolongs mouse heart survival in an ex vivo model of xenograft rejection by Chen, C G, Salvaris, E J, Romanella, M, Aminian, A, Katerelos, M, Fisicaro, N, d'Apice, A J, Pearse, M J

“…The expression of human alpha1,2-fucosyltransferase (H-transferase, HT) has been proposed as an alternative strategy to alpha1,3-galactosyltransferase (GT)…”
Get full text