Prognostic factors in T3,N0-1 glottic and transglottic carcinoma. A multifactorial study of 221 cases treated by surgery or radiotherapy

Prognostic factors in T3,N0-1 glottic and transglottic carcinoma. A multifactorial study of 221 cases treated by surgery or radiotherapy

To evaluate prognostic factors in patients with T3,N0-1 glottic and transglottic carcinoma treated in a single institution. Retrospective, nonrandomized case series. Tertiary case referral centers, ambulatory or hospitalized care. Two hundred twenty-one consecutive cases of stage III glottic or tran...

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Bibliographic Details
Published in:Archives of otolaryngology--head & neck surgery Vol. 122; no. 1; p. 77
Main Authors: Kowalski, L P, Batista, M B, Santos, C R, Scopel, A, Salvajolli, J V, Torloni, H
Format: Journal Article
Language:English
Published: United States 01-01-1996
Subjects:
Actuarial Analysis
Aged
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Female
Glottis
Humans
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - therapy
Laryngectomy
Male
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Radiotherapy, Adjuvant
Retrospective Studies
Survival Analysis
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Summary:To evaluate prognostic factors in patients with T3,N0-1 glottic and transglottic carcinoma treated in a single institution. Retrospective, nonrandomized case series. Tertiary case referral centers, ambulatory or hospitalized care. Two hundred twenty-one consecutive cases of stage III glottic or transglottic squamous cell carcinoma. Tumor stage was T3,N0,M0 in 167 cases and T3,N1,M0 in 54 cases. Surgery in 176 cases and radiotherapy in 45 cases. Recurrences and survival (multivariate). Almost 7% of the patients who underwent surgery and 39.6% who had radiotherapy had local recurrences. Recurrences in the neck were seen in 16.4% of the patients who underwent surgery and in 10.5% of those who had radiotherapy. Distant metastases were diagnosed only in patients who underwent surgery (4.6%). The 5-year actuarial overall survival rates were 56.3% in the surgical group and 35.2% in the radiotherapy group (P = .007). Age involvement of pyriform sinus, N stage, and history of tracheostomy were independent prognostic factors for risk of death. The presence of metastatic lymph nodes, age, and involvement of the pyriform sinus were the important prognostic factors in patients who underwent surgery. A small group of patients with T3,N0,M0 tumors could benefit from radiotherapy, with surgery reserved for recurrence.
ISSN:0886-4470
DOI:10.1001/archotol.1996.01890130069011