Blueberry extract improves redox balance and functional parameters in the right ventricle from rats with pulmonary arterial hypertension

Purpose Pulmonary arterial hypertension (PAH) is a disease characterized by increased pulmonary vascular resistance and right ventricle (RV) failure. In this context, oxidative stress is an essential element contributing to PAH’s pathophysiology. Thus, blueberry (BB), which has a high antioxidant ca...

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Bibliographic Details
Published in:	European journal of nutrition Vol. 61; no. 1; pp. 373 - 386
Main Authors:	Türck, Patrick, Salvador, Isadora Schein, Campos-Carraro, Cristina, Ortiz, Vanessa, Bahr, Alan, Andrades, Michael, Belló-Klein, Adriane, da Rosa Araujo, Alex Sander
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2022 Springer Nature B.V
Subjects:	Animal models Animals Antioxidants Blood pressure Blueberry Plants Cardiovascular diseases Catalase Catheterization Chemistry Chemistry and Materials Science Disease Models, Animal Echocardiography Heart Ventricles Hypertension Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - drug therapy Hypertrophy Lipid peroxidation Lung diseases Male Monocrotaline NAD(P)H oxidase Nutrition Original Contribution Oxidation-Reduction Oxidative stress Pathophysiology Plant Extracts - pharmacology Pulmonary Arterial Hypertension Pulmonary arteries Pulmonary artery Pulmonary hypertension Rats Rats, Wistar Redox properties Ventricle Oxidative stress Blueberry Right ventricle Monocrotaline Pulmonary hypertension
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Summary:	Purpose Pulmonary arterial hypertension (PAH) is a disease characterized by increased pulmonary vascular resistance and right ventricle (RV) failure. In this context, oxidative stress is an essential element contributing to PAH’s pathophysiology. Thus, blueberry (BB), which has a high antioxidant capacity, emerges as a natural therapeutic approach in PAH. This work evaluated the effect of BB extract on redox balance in RV in a PAH’s animal model. Methods Male Wistar rats (200 ± 20 g) ( n = 72) were randomized into eight groups: control (CTR); monocrotaline (MCT); CTR and MCT treated at doses of 50, 100, and 200 mg/kg BB. PAH was induced by administration of MCT (60 mg/kg, intraperitoneal). Rats were treated with BB orally for 5 weeks (2 weeks before monocrotaline and 3 weeks after monocrotaline injection). On day 35, rats were submitted to echocardiography and catheterization, then euthanasia and RV harvesting for biochemical analyses. Results RV hypertrophy, observed in the MCT groups, was reduced with BB treatment. MCT elevated RV systolic pressure and pressure/time derivatives, while the intervention with BB decreased these parameters. PAH decreased RV output and pulmonary artery outflow acceleration/ejection time ratio, while increased RV diameters, parameters restored by BB treatment. Animals from the MCT group showed elevated lipid peroxidation and NADPH oxidase activity, outcomes attenuated in animals treated with BB, which also led to increased catalase activity. Conclusion Treatment with BB partially mitigated PAH, which could be associated with improvement of RV redox state. Such findings constitute an advance in the investigation of the role of BB extract in chronic progressive cardiovascular diseases that involve the redox balance, such as PAH.
ISSN:	1436-6207 1436-6215
DOI:	10.1007/s00394-021-02642-9