Search Results - "Saltzberg, Daniel J"

Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain by Rafiei, Atefeh, Cruz Tetlalmatzi, Sofía, Edrington, Claire H, Lee, Linda, Crowder, D Alex, Saltzberg, Daniel J, Sali, Andrej, Brouhard, Gary, Schriemer, David C

“…Doublecortin (DCX) is a microtubule (MT)-associated protein that regulates MT structure and function during neuronal development and mutations in DCX lead to a…”
Get full text

Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs by Farelli, Jeremiah D, Galvin, Brendan D, Li, Zhiru, Liu, Chunliang, Aono, Miyuki, Garland, Megan, Hallett, Olivia E, Causey, Thomas B, Ali-Reynolds, Alana, Saltzberg, Daniel J, Carlow, Clotilde K S, Dunaway-Mariano, Debra, Allen, Karen N

“…Parasitic nematodes are responsible for devastating illnesses that plague many of the world's poorest populations indigenous to the tropical areas of…”
Get full text

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing by Gordon, David E, Jang, Gwendolyn M, Bouhaddou, Mehdi, Xu, Jiewei, Obernier, Kirsten, White, Kris M, O'Meara, Matthew J, Rezelj, Veronica V, Guo, Jeffrey Z, Swaney, Danielle L, Tummino, Tia A, Hüttenhain, Ruth, Kaake, Robyn M, Richards, Alicia L, Tutuncuoglu, Beril, Foussard, Helene, Batra, Jyoti, Haas, Kelsey, Modak, Maya, Kim, Minkyu, Haas, Paige, Polacco, Benjamin J, Braberg, Hannes, Fabius, Jacqueline M, Eckhardt, Manon, Soucheray, Margaret, Bennett, Melanie J, Cakir, Merve, McGregor, Michael J, Li, Qiongyu, Meyer, Bjoern, Roesch, Ferdinand, Vallet, Thomas, Mac Kain, Alice, Miorin, Lisa, Moreno, Elena, Naing, Zun Zar Chi, Zhou, Yuan, Peng, Shiming, Shi, Ying, Zhang, Ziyang, Shen, Wenqi, Kirby, Ilsa T, Melnyk, James E, Chorba, John S, Lou, Kevin, Dai, Shizhong A, Barrio-Hernandez, Inigo, Memon, Danish, Hernandez-Armenta, Claudia, Lyu, Jiankun, Mathy, Christopher J P, Perica, Tina, Pilla, Kala Bharath, Ganesan, Sai J, Saltzberg, Daniel J, Rakesh, Ramachandran, Liu, Xi, Rosenthal, Sara B, Calviello, Lorenzo, Venkataramanan, Srivats, Liboy-Lugo, Jose, Lin, Yizhu, Huang, Xi-Ping, Liu, YongFeng, Wankowicz, Stephanie A, Bohn, Markus, Safari, Maliheh, Ugur, Fatima S, Koh, Cassandra, Savar, Nastaran Sadat, Tran, Quang Dinh, Shengjuler, Djoshkun, Fletcher, Sabrina J, O'Neal, Michael C, Cai, Yiming, Chang, Jason C J, Broadhurst, David J, Klippsten, Saker, Sharp, Phillip P, Wenzell, Nicole A, Kuzuoglu-Ozturk, Duygu, Wang, Hao-Yuan, Trenker, Raphael, Young, Janet M, Cavero, Devin A, Hiatt, Joseph, Roth, Theodore L, Rathore, Ujjwal, Subramanian, Advait, Noack, Julia, Hubert, Mathieu, Stroud, Robert M, Frankel, Alan D, Rosenberg, Oren S, Verba, Kliment A, Agard, David A, Ott, Melanie, Emerman, Michael, Jura, Natalia

“…A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019…”
Get full text

Using Integrative Modeling Platform to compute, validate, and archive a model of a protein complex structure by Saltzberg, Daniel J., Viswanath, Shruthi, Echeverria, Ignacia, Chemmama, Ilan E., Webb, Ben, Sali, Andrej

“…Biology is advanced by producing structural models of biological systems, such as protein complexes. Some systems are recalcitrant to traditional structure…”
Get full text

The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex by Hepburn, Morgan, Saltzberg, Daniel J., Lee, Linda, Fang, Shujuan, Atkinson, Claire, Strynadka, Natalie C.J., Sali, Andrej, Lees-Miller, Susan P., Schriemer, David C.

“…In the non-homologous end-joining (NHEJ) of a DNA double-strand break, DNA ends are bound and protected by DNA-PK, which synapses across the break to tether…”
Get full text

A Residue-Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen–Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein–Ligand Interactions by Saltzberg, Daniel J, Broughton, Howard B, Pellarin, Riccardo, Chalmers, Michael J, Espada, Alfonso, Dodge, Jeffrey A, Pascal, Bruce D, Griffin, Patrick R, Humblet, Christine, Sali, Andrej

“…Characterization of interactions between proteins and other molecules is crucial for understanding the mechanisms of action of biological systems and, thus,…”
Get full text

Glutamine Side Chain 13C18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly by Wu, Haifan, Saltzberg, Daniel J, Kratochvil, Huong T, Jo, Hyunil, Sali, Andrej, DeGrado, William F

“…Infrared (IR) spectroscopy has provided considerable insight into the structures, dynamics, and formation mechanisms of amyloid fibrils. IR probes, such as…”
Get full text

Glutamine Side Chain 13 C═ 18 O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly by Wu, Haifan, Saltzberg, Daniel J, Kratochvil, Huong T, Jo, Hyunil, Sali, Andrej, DeGrado, William F

“…Infrared (IR) spectroscopy has provided considerable insight into the structures, dynamics, and formation mechanisms of amyloid fibrils. IR probes, such as…”
Get full text

SSEThread: Integrative threading of the DNA-PKcs sequence based on data from chemical cross-linking and hydrogen deuterium exchange by Saltzberg, Daniel J., Hepburn, Morgan, Pilla, Kala Bharath, Schriemer, David C., Lees-Miller, Susan P., Blundell, Tom L., Sali, Andrej

“…X-ray crystallography and electron microscopy maps resolved to 3–8 Å are generally sufficient for tracing the path of the polypeptide chain in space, while…”
Get full text

Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions by Watts, Joel C, Giles, Kurt, Saltzberg, Daniel J, Dugger, Brittany N, Patel, Smita, Oehler, Abby, Bhardwaj, Sumita, Sali, Andrej, Prusiner, Stanley B

“…The biochemical and neuropathological properties of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) prions are faithfully…”
Get full text

Structure of the Trehalose-6-phosphate Phosphatase from Brugia malayi Reveals Key Design Principles for Anthelmintic Drugs: e1004245 by Farelli, Jeremiah D, Galvin, Brendan D, Li, Zhiru, Liu, Chunliang, Aono, Miyuki, Garland, Megan, Hallett, Olivia E, Causey, Thomas B, Ali-Reynolds, Alana, Saltzberg, Daniel J, Carlow, Clotilde KS, Dunaway-Mariano, Debra, Allen, Karen N

“…Parasitic nematodes are responsible for devastating illnesses that plague many of the world's poorest populations indigenous to the tropical areas of…”
Get full text