Search Results - "Saltos, N"

Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial by Creelan, Benjamin C., Wang, Chao, Teer, Jamie K., Toloza, Eric M., Yao, Jiqiang, Kim, Sungjune, Landin, Ana M., Mullinax, John E., Saller, James J., Saltos, Andreas N., Noyes, David R., Montoya, Leighann B., Curry, Wesley, Pilon-Thomas, Shari A., Chiappori, Alberto A., Tanvetyanon, Tawee, Kaye, Frederic J., Thompson, Zachary J., Yoder, Sean J., Fang, Bin, Koomen, John M., Sarnaik, Amod A., Chen, Dung-Tsa, Conejo-Garcia, Jose R., Haura, Eric B., Antonia, Scott J.

“…Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small…”
Get full text

Utilization of target lesion heterogeneity for treatment efficacy assessment in late stage lung cancer by Chen, Dung-Tsa, Chan, Wenyaw, Thompson, Zachary J, Thapa, Ram, Beg, Amer A, Saltos, Andreas N, Chiappori, Alberto A, Gray, Jhanelle E, Haura, Eric B, Rose, Trevor A, Creelan, Ben

“…Rationale Recent studies have discovered several unique tumor response subgroups outside of response classification by Response Evaluation Criteria for Solid…”
Get full text

Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8 by Gibson, P G, Simpson, J L, Saltos, N

“…To identify the characteristics of airway inflammation in persistent asthma and to examine the role of neutrophilic inflammation in noneosinophilic persistent…”
Get more information

Trastuzumab Deruxtecan in HER2-Mutant Non–Small-Cell Lung Cancer by Li, Bob T, Smit, Egbert F, Goto, Yasushi, Nakagawa, Kazuhiko, Udagawa, Hibiki, Mazières, Julien, Nagasaka, Misako, Bazhenova, Lyudmila, Saltos, Andreas N, Felip, Enriqueta, Pacheco, Jose M, Pérol, Maurice, Paz-Ares, Luis, Saxena, Kapil, Shiga, Ryota, Cheng, Yingkai, Acharyya, Suddhasatta, Vitazka, Patrik, Shahidi, Javad, Planchard, David, Jänne, Pasi A

“…A multicenter phase 2 study looked at the capacity of the antibody–drug conjugate trastuzumab deruxtecan to induce responses in HER2 -mutant lung cancer. The…”
Get full text

Race‐inclusive and equitable access to immune checkpoint inhibitor therapy: What are the biggest hurdles? by Puri, Sonam, Saltos, Andreas N., Gray, Jhanelle E.

“…A real‐world data analysis evaluating the clinical outcomes of consolidation durvalumab after concurrent chemoradiation in Black versus non‐Black patients with…”
Get full text

629-D The anti-tumor activity of IFNβ and membrane-stable CD40L expressing oncolytic virus MEM-288 in NSCLC patients is associated with modulation of the tumor microenvironment and systemic immune response by Saltos, Andreas N, Arrowood, Christy, Beasley, Georgia M, Ronald, James, El-Haddad, Ghassan, Gray, Jhanelle E, Pellini, Bruna, Tanvetyanon, Tawee, Guerra-Guevara, Luiziane, Khan, Uzma, Wolf, Steven, Gu, Lin, Wang, Xiaofei, Zheng, Hong, Foresman, Dana, Yu, Xiaoqing, Cantwell, Mark J, Antonia, Scott J, Beg, Amer A, Ready, Neal E

“…BackgroundMEM-288 is a conditionally replicative oncolytic adenovirus expressing human IFNβ and a recombinant membrane-stable form of CD40L (MEM40)…”
Get full text

Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis by Gibson, P.G, Wark, P.A.B, Simpson, J.L, Meldrum, C, Meldrum, S, Saltos, N, Boyle, M

“…Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to the fungus Aspergillus fumigatus, causing severe asthma that may progress to…”
Get full text

Induced sputum eosinophils and neutrophils and bronchiectasis severity in allergic bronchopulmonary aspergillosis by Wark, PA, Saltos, N, Simpson, J, Slater, S, Hensley, MJ, Gibson, PG

“…Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to the fungus Aspergillus fumigatus that may progress to bronchiectasis. The aim…”
Get full text

A phase I/IB trial of binimetinib in combination with erlotinib in NSCLC harboring activating KRAS or EGFR mutations by Saltos, Andreas N., Creelan, Ben C., Tanvetyanon, Tawee, Chiappori, Alberto A., Antonia, Scott J., Shafique, Michael R., Ugrenovic-Petrovic, Milijana, Sansil, Samer, Neuger, Anthony, Ozakinci, Hilal, Boyle, Theresa A., Kim, Jongphil, Haura, Eric B., Gray, Jhanelle E.

“…•Erlotinib 100 mg daily and binimetinib 15 mg BID × 5 days/week was well tolerated.•Common toxicities observed included grade 1–2 diarrhea, rash, fatigue, and…”
Get full text

Implementation of a High-Accuracy Targeted Gene Expression Panel for Clinical Care by Alontaga, Aileen Y., Cano, Pedro, Ozakinci, Hilal, Puskas, John A., Stewart, Paul A., Welsh, Eric A., Yoder, Sean J., Hicks, J. Kevin, Saltos, Andreas N., Bossler, Aaron D., Haura, Eric B., Koomen, John M., Boyle, Theresa A.

“…This study describes the validation of a clinical RNA expression panel with evaluation of concordance between gene copy gain by a next-generation sequencing…”
Get full text

Dose-Limiting Pulmonary Toxicity in a Phase 1/2 Study of Radiation and Chemotherapy with Ipilimumab Followed by Nivolumab for Patients With Stage 3 Unresectable Non-Small Cell Lung Cancer by Liveringhouse, Casey L., Latifi, Kujtim, Asous, Amalin G., Lam, Nghi B., Rosenberg, Stephen A., Dilling, Thomas J., MacMillan, Gretchen V., Chiappori, Alberto A., Haura, Eric B., Creelan, Ben, Gray, Jhanelle E., Tanvetyanon, Tawee, Shafique, Michael R., Saltos, Andreas N., Weiner, Ashley A., Clarke, Jeffrey, Kelsey, Christopher R., Kim, Sungjune, Caudell, James J., Rose, Trevor A., Conejo-Garcia, Jose R., Li, Jiannong, Schell, Michael J., Antonia, Scott J., Perez, Bradford A.

“…We hypothesized that concurrent ipilimumab with chemoradiationtherapy (chemoRT) followed by maintenance nivolumab would be safe for patients with unresectable…”
Get full text

CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors by Araujo, Haniel A., Do, Minh Truong, Qian, Yu, Sun, Xin, Montesion, Meagan, Palmer, Rachael, Jahchan, Nadine, Juan, Joseph M., Min, Chengyin, Yu, Yi, Pan, Xuewen, Arbour, Kathryn C., Vokes, Natalie, Molkentine, David, Owen, Dwight H., Memmott, Regan, Patil, Pradnya D., Marmarelis, Melina E., Awad, Mark M., Murray, Joseph C., Hellyer, Jessica A., Gainor, Justin F., Dimou, Anastasios, Bestvina, Christine M., Shu, Catherine A., Riess, Jonathan W., Blakely, Collin M., Mezquita, Laura, Tabbó, Fabrizio, Scheffler, Matthias, Digumarthy, Subba, Sacher, Adrian G., Lau, Sally C. M., Saltos, Andreas N., Rotow, Julia, Johnson, Rocio Perez, Liu, Corinne, Stewart, Tyler, Goldberg, Sarah B., Killam, Jonathan, Walther, Zenta, Schalper, Kurt, Davies, Kurtis D., Anagnostou, Valsamo, Marrone, Kristen A., Forde, Patrick M., Ricciuti, Biagio, Venkatraman, Deepti, Goldman, Jonathan W., Shaish, Hiram, Katz, Sharyn, Azok, Joseph T., Segal, Jeremy, Neal, Joel W., Lacroix, Ludovic, Elamin, Yasir Y., Negrao, Marcelo V., Le, Xiuning, Lam, Vincent K., Lewis, Whitney E., Carter, Brett, Roth, Jack A., Swisher, Stephen, Zhou, Teng, Poteete, Alissa, Kong, Yifan, Takehara, Tomohiro, Paula, Alvaro Guimaraes, Parra Cuentas, Edwin R., Blumenschein, George R., Byers, Lauren A., Gibbons, Don L., Tsao, Anne, Bivona, Trever G., Lieghl, Natasha, Levy, Benjamin, Brahmer, Julie R., Garassino, Marina C., Gandara, David R., Rizvi, Naiyer A., Scagliotti, Giorgio Vittorio, Wolf, Jürgen, Planchard, David, Besse, Benjamin, Wakelee, Heather A., Pennell, Nathan A., Shaw, Alice T., Jänne, Pasi A., Rudin, Charles M., Albacker, Lee, Mann, Helen, Lai, Zhongwu, Peters, Solange, Wong, Kwok K., Huang, Alan, Winslow, Monte M., Winters, Ian P., Papadimitrakopoulou, Vassiliki A., Cascone, Tina, Jewsbury, Philip

“…For patients with advanced non-small-cell lung cancer (NSCLC), dual immune checkpoint blockade (ICB) with CTLA4 inhibitors and PD-1 or PD-L1 inhibitors…”
Get full text

Early Adverse Event Derived Biomarkers in Predicting Clinical Outcomes in Patients with Advanced Non-Small Cell Lung Cancer Treated with Immunotherapy by Chen, Dung-Tsa, Saltos, Andreas N, Rose, Trevor, Thompson, Zachary J, Thapa, Ram, Chiappori, Alberto, Gray, Jhanelle E

“…Adverse events (AEs) have been shown to have clinical associations, in addition to patient safety assessments of drugs of interest. However, due to their…”
Get full text

Combination IFNβ and Membrane-Stable CD40L Maximize Tumor Dendritic Cell Activation and Lymph Node Trafficking to Elicit Systemic T-cell Immunity by Zheng, Hong, Yu, Xiaoqing, Ibrahim, Mohammed L, Foresman, Dana, Xie, Mengyu, Johnson, Joseph O, Boyle, Theresa A, Ruffell, Brian, Perez, Bradford A, Antonia, Scott J, Ready, Neal, Saltos, Andreas N, Cantwell, Mark J, Beg, Amer A

“…Oncolytic virus therapies induce the direct killing of tumor cells and activation of conventional dendritic cells (cDC); however, cDC activation has not been…”
Get more information

Induced sputum eosinophil cationic protein (ECP) measurement in asthma and chronic obstructive airway disease (COAD) by GIBSON, P. G, WOOLLEY, K. L, CARTY, K, MURREE-ALLEN, K, SALTOS, N

“…Background Induced sputum is a useful way to monitor airway inflammation in asthma, but cell counts are time‐consuming and labour intensive. Objective The aim…”
Get full text

Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: A randomized controlled trial by Wark, Peter Alexander Blanch, Hensley, Michael John, Saltos, Nicholas, Boyle, Michael James, Toneguzzi, Ruth Christine, Epid, Grad Dip Clin, Simpson, Jodie Louise, McElduff, Patrick, Gibson, Peter Gerard

“…Background: Allergic bronchopulmonary aspergillosis (ABPA) complicates chronic asthma and results from hypersensitivity to the fungus Aspergillus fumigatu s,…”
Get full text

Acute anti-inflammatory effects of inhaled budesonide in asthma: A randomized controlled trial by GIBSON, Peter G, SALTOS, Nicholas, FAKES, Kellie

“…Corticosteroids can have acute effects on airway function and methacholine airway responsiveness in asthma as early as 6 h after dosing, suggesting there may…”
Get full text

Airway mast cells and eosinophils correlate with clinical severity and airway hyperresponsiveness in corticosteroid-treated asthma by Gibson, Peter G., Saltos, Nicholas, Borgas, Trevor

“…Background: The relationship between airway inflammation and asthma severity in corticosteroid-treated asthma is unclear. Objectives: Our purpose was to…”
Get full text

Abstract 6655: Oncolytic adenovirus dually expressing interferon beta and membrane-stable CD40 ligand increases polyfunctional CD8+T cells associated with antitumor activity by Cantwell, Mark J., Saltos, Andreas N., Zheng, Hong, Foresman, Dana, Beg, Amer A.

“…MEM-288 is a dual-transgene armed oncolytic adenovirus in phase 1 clinical development as a standalone agent and in combination with immune checkpoint…”
Get full text

Prospective Phase I/II Study of Radiation and Chemotherapy With Ipilimumab Followed by Nivolumab for Patients With Stage III Unresectable NSCLC by Liveringhouse, C., Lam, N.B., Rosenberg, S.A., Dilling, T.J., Macmillan, G., Chiappori, A., Haura, E.B., Creelan, B., Gray, J., Tanvetyanon, T., Shafique, M., Saltos, A.N., Weiner, A.A., Kelsey, C.R., Schell, M., Antonia, S.J., Perez, B.A.

“…We hypothesized that the addition of concurrent ipilimumab (IPI) with chemoradiotherapy followed by consolidative nivolumab (NIVO) would be safe and tolerable…”
Get full text