Search Results - "Salter, Russell D"

Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation by Heid, Michelle E, Keyel, Peter A, Kamga, Christelle, Shiva, Sruti, Watkins, Simon C, Salter, Russell D

“…The nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome drives many inflammatory processes and…”
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Functional Connectivity between Immune Cells Mediated by Tunneling Nanotubules by Watkins, Simon C., Salter, Russell D.

“…Intercellular signals can be transmitted through neuronal synapses or through gap junctions, with the latter mediating transmission of calcium fluxes and small…”
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Activation of macrophages by P2X7-induced microvesicles from myeloid cells is mediated by phospholipids and is partially dependent on TLR4 by Thomas, L Michael, Salter, Russell D

“…ATP-mediated activation of the purinergic receptor P2X(7) elicits morphological changes and proinflammatory responses in macrophages. These changes include…”
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Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner by Chu, Jessica, Thomas, L. Michael, Watkins, Simon C., Franchi, Luigi, Núñez, Gabriel, Salter, Russell D.

“…This study explores the mechanism by which a bacterial toxin induces the secretion of a proinflammatory cytokine from innate immune cells. CDC are exotoxins…”
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Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion by Shi, Guilan, Abbott, Kennady N, Wu, Wenbo, Salter, Russell D, Keyel, Peter A

“…Pediatric-onset systemic lupus erythematosus arises in humans and mice lacking the endonuclease Dnase1L3. When Dnase1L3 is absent, DNA from circulating…”
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CD40L induces functional tunneling nanotube networks exclusively in dendritic cells programmed by mediators of type 1 immunity by Zaccard, Colleen R, Watkins, Simon C, Kalinski, Pawel, Fecek, Ronald J, Yates, Aarika L, Salter, Russell D, Ayyavoo, Velpandi, Rinaldo, Charles R, Mailliard, Robbie B

“…The ability of dendritic cells (DC) to mediate CD4(+) T cell help for cellular immunity is guided by instructive signals received during DC maturation, as well…”
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Genetically Encoded pH Sensor for Tracking Surface Proteins through Endocytosis by Grover, Anmol, Schmidt, Brigitte F., Salter, Russell D., Watkins, Simon C., Waggoner, Alan S., Bruchez, Marcel P.

“…Traffic cam: A tandem dye prepared from a FRET acceptor and a fluorogenic donor functions as a cell surface ratiometric pH indicator, which upon…”
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The second transmembrane domain of P2X7 contributes to dilated pore formation by Sun, Chengqun, Heid, Michelle E, Keyel, Peter A, Salter, Russell D

“…Activation of the purinergic receptor P2X7 leads to the cellular permeability of low molecular weight cations. To determine which domains of P2X7 are necessary…”
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Methylthioadenosine reprograms macrophage activation through adenosine receptor stimulation by Keyel, Peter A, Romero, Matthew, Wu, Wenbo, Kwak, Daniel H, Zhu, Qin, Liu, Xinyu, Salter, Russell D

“…Regulation of inflammation is necessary to balance sufficient pathogen clearance with excessive tissue damage. Central to regulating inflammation is the switch…”
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Reduction of streptolysin O (SLO) pore-forming activity enhances inflammasome activation by Keyel, Peter A, Roth, Robyn, Yokoyama, Wayne M, Heuser, John E, Salter, Russell D

“…Pore-forming toxins are utilized by bacterial and mammalian cells to exert pathogenic effects and induce cell lysis. In addition to rapid plasma membrane…”
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Macrophage responses to bacterial toxins: a balance between activation and suppression by Keyel, Peter A., Heid, Michelle E., Salter, Russell D.

“…Toxins secreted by bacteria can impact the host in a number of different ways. In some infections, toxins play a crucial and central role in pathogenesis…”
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Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque by Zinman, Guy, Brower-Sinning, Rachel, Emeche, Chineye H, Ernst, Jason, Huang, Grace Tzu-Wei, Mahony, Shaun, Myers, Amy J, O'Dee, Dawn M, Flynn, JoAnne L, Nau, Gerard J, Ross, Ted M, Salter, Russell D, Benos, Panayiotis V, Bar Joseph, Ziv, Morel, Penelope A

“…Viral and bacterial infections of the lower respiratory tract are major causes of morbidity and mortality worldwide. Alveolar macrophages line the alveolar…”
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Preventive immunization of aged and juvenile non-human primates to β-amyloid by Kofler, Julia, Lopresti, Brian, Janssen, Chris, Trichel, Anita M, Masliah, Eliezer, Finn, Olivera J, Salter, Russell D, Murdoch, Geoffrey H, Mathis, Chester A, Wiley, Clayton A

“…Immunization against beta-amyloid (Aβ) is a promising approach for the treatment of Alzheimer's disease, but the optimal timing for the vaccination remains to…”
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Visualization of bacterial toxin induced responses using live cell fluorescence microscopy by Keyel, Peter A, Heid, Michelle E, Watkins, Simon C, Salter, Russell D

“…Bacterial toxins bind to cholesterol in membranes, forming pores that allow for leakage of cellular contents and influx of materials from the external…”
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Binding and Uptake of Agalactosyl IgG by Mannose Receptor on Macrophages and Dendritic Cells by Dong, Xin, Storkus, Walter J, Salter, Russell D

“…Increased levels of agalactosyl IgG (G0 IgG) are found in several autoimmune diseases, including rheumatoid arthritis, in which they are correlated with…”
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Streptolysin O clearance through sequestration into blebs that bud passively from the plasma membrane by Keyel, Peter A, Loultcheva, Lyussiena, Roth, Robyn, Salter, Russell D, Watkins, Simon C, Yokoyama, Wayne M, Heuser, John E

“…Cells survive exposure to bacterial pore-forming toxins, such as streptolysin O (SLO), through mechanisms that remain unclear. Previous studies have suggested…”
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Dendritic cell altered states: what role for calcium? by Salter, Russell D., Watkins, Simon C.

“…Ca2+‐driven responses in dendritic cells (DCs) are less well characterized than in lymphocytes. When DCs undergo a sequence of activation/maturation events,…”
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Coordinate stimulation of macrophages by microparticles and TLR ligands induces foam cell formation by Keyel, Peter A, Tkacheva, Olga A, Larregina, Adriana T, Salter, Russell D

“…Aberrant activation of macrophages in arterial walls by oxidized lipoproteins can lead to atherosclerosis. Oxidized lipoproteins convert macrophages to foam…”
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Tn-MUC1 DC Vaccination of Rhesus Macaques and a Phase I/II Trial in Patients with Nonmetastatic Castrate-Resistant Prostate Cancer by Scheid, Elizabeth, Major, Pierre, Bergeron, Alain, Finn, Olivera J, Salter, Russell D, Eady, Robin, Yassine-Diab, Bader, Favre, David, Peretz, Yoav, Landry, Claire, Hotte, Sebastien, Mukherjee, Som D, Dekaban, Gregory A, Fink, Corby, Foster, Paula J, Gaudet, Jeffery, Gariepy, Jean, Sekaly, Rafick-Pierre, Lacombe, Louis, Fradet, Yves, Foley, Ronan

“…MUC1 is a glycoprotein expressed on the apical surface of ductal epithelial cells. Malignant transformation results in loss of polarization and overexpression…”
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Identification and characterization of a novel variant of the human P2X7 receptor resulting in gain of function by Sun, Chengqun, Chu, Jessica, Singh, Sarita, Salter, Russell D.

“…The P2X 7 receptor exhibits significant allelic polymorphism in humans, with both loss and gain of function variants potentially impacting on a variety of…”
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