Search Results - "Salter, Jason D"

The APOBEC Protein Family: United by Structure, Divergent in Function by Salter, Jason D., Bennett, Ryan P., Smith, Harold C.

“…The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins have diverse and important functions in human health and disease…”
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Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid Ligands by Salter, Jason D., Smith, Harold C.

“…The 11-member APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of zinc-dependent cytidine deaminases bind to RNA and single-stranded…”
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Structural insights for HIV-1 therapeutic strategies targeting Vif by Salter, Jason D., Morales, Guillermo A., Smith, Harold C.

“…•APOBEC binding residues of Vif form contiguous surface regions.•Vif utilizes at least two different interfaces to target APOBEC3 family members.•A potential…”
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RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates by Polevoda, Bogdan, McDougall, William M, Tun, Bradley N, Cheung, Michael, Salter, Jason D, Friedman, Alan E, Smith, Harold C

“…APOBEC3G (A3G) DNA deaminase activity requires a holoenzyme complex whose assembly on nascent viral reverse transcripts initiates with A3G dimers binding to…”
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Calcium and mitochondria by Gunter, Thomas E., Yule, David I., Gunter, Karlene K., Eliseev, Roman A., Salter, Jason D.

“…The literature suggests that the physiological functions for which mitochondria sequester Ca2+ are (1) to stimulate and control the rate of oxidative…”
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A Novel Ebola Virus VP40 Matrix Protein-Based Screening for Identification of Novel Candidate Medical Countermeasures by Bennett, Ryan P, Finch, Courtney L, Postnikova, Elena N, Stewart, Ryan A, Cai, Yingyun, Yu, Shuiqing, Liang, Janie, Dyall, Julie, Salter, Jason D, Smith, Harold C, Kuhn, Jens H

“…Filoviruses, such as Ebola virus and Marburg virus, are of significant human health concern. From 2013 to 2016, Ebola virus caused 11,323 fatalities in Western…”
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The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions by Prohaska, Kimberly M., Bennett, Ryan P., Salter, Jason D., Smith, Harold C.

“…Cytidine deaminases have important roles in the regulation of nucleoside/deoxynucleoside pools for DNA and RNA synthesis. The APOBEC family of cytidine…”
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APOBEC3G Subunits Self-associate via the C-terminal Deaminase Domain by Bennett, Ryan P., Salter, Jason D., Liu, Xiang, Wedekind, Joseph E., Smith, Harold C.

“…Human APOBEC3G (hA3G) is a cytidine deaminase active on HIV single-stranded DNA. Small angle x-ray scattering and molecular envelope restorations predicted a…”
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Nanostructures of APOBEC3G Support a Hierarchical Assembly Model of High Molecular Mass Ribonucleoprotein Particles from Dimeric Subunits by Wedekind, Joseph E., Gillilan, Richard, Janda, Alena, Krucinska, Jolanta, Salter, Jason D., Bennett, Ryan P., Raina, Jay, Smith, Harold C.

“…Human APOBEC3G (hA3G) is a cytidine deaminase that restricts human immunodeficiency virus (HIV)-1 infection in a vif (the virion infectivity factor from…”
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Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase by Bennett, Ryan P., Yoluç, Yasemin, Salter, Jason D., Ripp, Alexander, Jessen, Henning J., Kaiser, Stefanie M., Smith, Harold C.

“…Sangivamycin (S) is an adenosine (A) nucleoside analog with low nanomolar antiviral activity against SARS-CoV-2 in vitro. Previously, low nanomolar antiviral…”
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A New Class of Antiretroviral Enabling Innate Immunity by Protecting APOBEC3 from HIV Vif-Dependent Degradation by Bennett, Ryan P., Salter, Jason D., Smith, Harold C.

“…The infectivity of HIV depends on overcoming APOBEC3 (A3) innate immunity, predominantly through the expression of the viral protein Vif, which induces A3…”
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Corrigendum to “Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase” [Antivir. Res. 218 (2023) 105716–105728, doi: 10.1016/j.antiviral.2023.105716] by Bennett, Ryan P., Yoluç, Yasemin, Salter, Jason D., Ripp, Alexander, Jessen, Henning J., Kaiser, Stefanie M., Smith, Harold C.

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Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling by Hoffman, David L, Salter, Jason D, Brookes, Paul S

“…Mitochondria are proposed to play an important role in hypoxic cell signaling. One currently accepted signaling paradigm is that the mitochondrial generation…”
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Structural and functional assessment of APOBEC3G macromolecular complexes by Polevoda, Bogdan, McDougall, William M., Bennett, Ryan P., Salter, Jason D., Smith, Harold C.

“…•The APOBEC share structural features but are divergent in expression and functions.•Methods for the functional and structural analysis of APOBEC have been…”
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An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation by Bennett, Ryan P., Stewart, Ryan A., Hogan, Priscilla A., Ptak, Roger G., Mankowski, Marie K., Hartman, Tracy L., Buckheit, Robert W., Snyder, Beth A., Salter, Jason D., Morales, Guillermo A., Smith, Harold C.

“…Camptothecin (CPT) is a natural product discovered to be active against various cancers through its ability to inhibit Topoisomerase I (TOP1). CPT analogs also…”
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Core-Binding Factor β Increases the Affinity between Human Cullin 5 and HIV‑1 Vif within an E3 Ligase Complex by Salter, Jason D, Lippa, Geoffrey M, Belashov, Ivan A, Wedekind, Joseph E

“…HIV-1 Vif masquerades as a receptor for a cellular E3 ligase harboring Elongin B, Elongin C, and Cullin 5 (EloB/C/Cul5) proteins that facilitate degradation of…”
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A Hydrodynamic Analysis of APOBEC3G Reveals a Monomer−Dimer−Tetramer Self-Association That Has Implications for Anti-HIV Function by Salter, Jason D, Krucinska, Jolanta, Raina, Jay, Smith, Harold C, Wedekind, Joseph E

“…The innate antiviral factor APOBEC3G (A3G) possesses RNA binding activity and deaminates HIV-1 DNA. High-molecular mass forms of A3G can be isolated from a…”
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Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme by MacElrevey, Celeste, Salter, Jason D, Krucinska, Jolanta, Wedekind, Joseph E

“…The hairpin ribozyme requires functional groups from Ade38 to achieve efficient bond cleavage or ligation. To identify molecular features that contribute to…”
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Regulation of Antiviral Innate Immunity Through APOBEC Ribonucleoprotein Complexes by Salter, Jason D, Polevoda, Bogdan, Bennett, Ryan P, Smith, Harold C

“…The DNA mutagenic enzyme known as APOBEC3G (A3G) plays a critical role in innate immunity to Human Immunodeficiency Virus-1 (HIV-1 ). A3G is a zinc-dependent…”
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Bcl-2 and tBid proteins counter-regulate mitochondrial potassium transport by Eliseev, Roman A., Salter, Jason D., Gunter, Karlene K., Gunter, Thomas E.

“…The mechanism of cytochrome c release from mitochondria in apoptosis remains obscure, although it is known to be regulated by bcl-2 family proteins. Here we…”
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