Search Results - "Salon, John A"

The significance of G protein-coupled receptor crystallography for drug discovery by Salon, John A, Lodowski, David T, Palczewski, Krzysztof

“…Crucial as molecular sensors for many vital physiological processes, seven-transmembrane domain G protein-coupled receptors (GPCRs) comprise the largest family…”
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Post-Translational Modifications of the Serotonin Type 4 Receptor Heterologously Expressed in Mouse Rod Cells by Salom, David, Wang, Benlian, Dong, Zhiqian, Sun, Wenyu, Padayatti, Pius, Jordan, Steven, Salon, John A, Palczewski, Krzysztof

“…G-Protein-coupled serotonin receptor type 4 (5-HT4R) is a pharmacological target implicated in a variety of gastrointestinal and nervous system disorders. As…”
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Heterologous Expression and Purification of the Serotonin Type 4 Receptor from Transgenic Mouse Retina by Salom, David, Wu, Nan, Sun, Wenyu, Dong, Zhiqian, Palczewski, Krzysztof, Jordan, Steven, Salon, John A

“…Recent breakthroughs in the solution of X-ray structures for G protein-coupled receptors (GPCRs) with diffusible ligands have employed extensively mutated or…”
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Heterologous Expression of the Adenosine A1 Receptor in Transgenic Mouse Retina by Li, Ning, Salom, David, Zhang, Li, Harris, Tim, Ballesteros, Juan A, Golczak, Marcin, Jastrzebska, Beata, Palczewski, Krzysztof, Kurahara, Carole, Juan, Todd, Jordan, Steven, Salon, John A

“…Traditional cell-based systems used to express integral membrane receptors have yet to produce protein samples of sufficient quality for structural study…”
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Development of multiplexed microarray binding assays for high-throughput drug discovery by Hong, Yulong, Liu, Li, Pai, Sadashiva, Graf, James N, Rao, Hongwei, Lynn, Jeffrey G, van Staden, Carlo, Lee, Paul H, Lai, Fang, Salon, John A

“…The ability to combine primary hit identification assays with target profiling would significantly streamline the current drug discovery process. Working…”
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Discovery of potent and selective small molecule NPY Y5 receptor antagonists by Islam, Imadul, Dhanoa, Dale, Finn, John, Du, Ping, Walker, Mary W, Salon, John A, Zhang, Jack, Gluchowski, Charles

“…The discovery of a new class of sulfonamide NPY Y5 receptor antagonists is described. Optimization of this series led to the identification of compounds with…”
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Distribution of a novel hypothalamic neuropeptide Y receptor gene and its absence in rat by Burkhoff, Amanda Milgram, Linemeyer, David L, Salon, John A

“…A recently reported Y receptor that has been confusingly referred to as both Y5 and Y2b has now been designated as Y6 by the IUPHAR organization. Using random…”
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GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2 by Jones, K A, Borowsky, B, Tamm, J A, Craig, D A, Durkin, M M, Dai, M, Yao, W J, Johnson, M, Gunwaldsen, C, Huang, L Y, Tang, C, Shen, Q, Salon, J A, Morse, K, Laz, T, Smith, K E, Nagarathnam, D, Noble, S A, Branchek, T A, Gerald, C

“…The principal inhibitory neurotransmitter GABA (gamma-aminobutyric acid) exerts its effects through two ligand-gated channels, GABA(A) and GABA(C) receptors,…”
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GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2 by JONES, K. A, BOROWSKY, B, CHENG TANG, QUANRONG SHEN, SALON, J. A, MORSE, K, LAZ, T, SMITH, K. E, NAGARATHNAM, D, NOBLE, S. A, BRANCHEK, T. A, GERALD, C, TAMM, J. A, CRAIG, D. A, DURKIN, M. M, MENG DAI, YAO, W.-J, JOHNSON, M, GUNWALDSEN, C, HUANG, L.-Y

“…The principal inhibitory neurotransmitter GABA (gamma-aminobutyric acid) exerts its effects through two ligand-gated channels, GABA(A) and GABA(C) receptors,…”
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Modeling the G-protein-coupled neuropeptide Y Y1 receptor agonist and antagonist binding sites by Du, P, Salon, J A, Tamm, J A, Hou, C, Cui, W, Walker, M W, Adham, N, Dhanoa, D S, Islam, I, Vaysse, P J, Dowling, B, Shifman, Y, Boyle, N, Rueger, H, Schmidlin, T, Yamaguchi, Y, Branchek, T A, Weinshank, R L, Gluchowski, C

“…Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor (GPCR) superfamily and mediate several physiological responses, such as blood pressure,…”
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GABA B receptors function as a heteromeric assembly of the subunits GABA B R1 and GABA B R2 by Jones, Kenneth A, Borowsky, Beth, Tamm, Joe A, Craig, Douglas A, Durkin, Margaret M, Dai, Meng, Yao, Wen-Jeng, Johnson, Mary, Gunwaldsen, Caryn, Huang, Ling-Yan, Tang, Cheng, Shen, Quanrong, Salon, John A, Morse, Kelley, Laz, Thomas, Smith, Kelli E, Nagarathnam, Dhanapalan, Noble, Stewart A, Branchek, Theresa A, Gerald, Christophe

“…The principal inhibitory neurotransmitter GABA (γ-aminobutyric acid) exerts its effects through two ligand-gated channels, GABAA and GABAC receptors, and a…”
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GABA sub(B) receptors function as a heteromeric assembly of the subunits GABA sub(B)R1 and GABA sub(B)R2 by Jones, KA, Borowsky, B, Tamm, JA, Craig, DA, Durkin, M M, Dai, Meng, Yao, Wen-Jeng, Johnson, M, Gunwaldsen, C, Huang, Ling-Yan, Tang, Cheng, Shen, Quanrong, Salon, JA, Gerald, C

“…The principal inhibitory neurotransmitter GABA ( gamma -aminobutyric acid) exerts its effects through two ligand-gated channels, GABA sub(A) and GABA sub(C)…”
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