Search Results - "Salomon, Arthur R"

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis by Curtis, Marion, Kenny, Hilary A., Ashcroft, Bradley, Mukherjee, Abir, Johnson, Alyssa, Zhang, Yilin, Helou, Ynes, Batlle, Raquel, Liu, Xiaojing, Gutierrez, Nuria, Gao, Xia, Yamada, S. Diane, Lastra, Ricardo, Montag, Anthony, Ahsan, Nagib, Locasale, Jason W., Salomon, Arthur R., Nebreda, Angel R., Lengyel, Ernst

“…Successful metastasis requires the co-evolution of stromal and cancer cells. We used stable isotope labeling of amino acids in cell culture coupled with…”
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Tandem Mass Tag Approach Utilizing Pervanadate BOOST Channels Delivers Deeper Quantitative Characterization of the Tyrosine Phosphoproteome by Chua, Xien Yu, Mensah, Theresa, Aballo, Timothy, Mackintosh, Samuel G., Edmondson, Ricky D., Salomon, Arthur R.

“…There are clear advantages to experimental approaches that reduce the amount of necessary cellular material for wide-scale quantitative profiling of the…”
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CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response by Qadir, Abdul S., Ceppi, Paolo, Brockway, Sonia, Law, Calvin, Mu, Liang, Khodarev, Nikolai N., Kim, Jung, Zhao, Jonathan C., Putzbach, William, Murmann, Andrea E., Chen, Zhuo, Chen, Wenjing, Liu, Xia, Salomon, Arthur R., Liu, Huiping, Weichselbaum, Ralph R., Yu, Jindan, Peter, Marcus E.

“…Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that this involves activation of signal transducer and activator of…”
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Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1) by Demirkan, Gokhan, Yu, Kebing, Boylan, Joan M, Salomon, Arthur R, Gruppuso, Philip A

“…Our understanding of signal transduction networks in the physiological context of an organism remains limited, partly due to the technical challenge of…”
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Proteomic profiling of Myc-associated proteins by Agrawal, Pooja, Yu, Kebing, Salomon, Arthur R., Sedivy, John M.

“…Mammalian c-Myc is a member of a small family of three closely related transcription factors. The Myc family of proto-oncogenes are among the most potent…”
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Cytochrome C is tyrosine 97 phosphorylated by neuroprotective insulin treatment by Sanderson, Thomas H, Mahapatra, Gargi, Pecina, Petr, Ji, Qinqin, Yu, Kebing, Sinkler, Christopher, Varughese, Ashwathy, Kumar, Rita, Bukowski, Melissa J, Tousignant, Renee N, Salomon, Arthur R, Lee, Icksoo, Hüttemann, Maik

“…Recent advancements in isolation techniques for cytochrome c (Cytc) have allowed us to discover post-translational modifications of this protein. We previously…”
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ERK positive feedback regulates a widespread network of tyrosine phosphorylation sites across canonical T cell signaling and actin cytoskeletal proteins in Jurkat T cells by Helou, Ynes A, Nguyen, Vinh, Beik, Samantha P, Salomon, Arthur R

“…Competing positive and negative signaling feedback pathways play a critical role in tuning the sensitivity of T cell receptor activation by creating an…”
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cAMP-dependent Tyrosine Phosphorylation of Subunit I Inhibits Cytochrome c Oxidase Activity by Lee, Icksoo, Salomon, Arthur R., Ficarro, Scott, Mathes, Isabella, Lottspeich, Friedrich, Grossman, Lawrence I., Hüttemann, Maik

“…Signaling pathways targeting mitochondria are poorly understood. We here examine phosphorylation by the cAMP-dependent pathway of subunits of cytochrome c…”
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A New Approach for Quantitative Phosphoproteomic Dissection of Signaling Pathways Applied to T Cell Receptor Activation by Nguyen, Vinh, Cao, Lulu, Lin, Jonathan T., Hung, Norris, Ritz, Anna, Yu, Kebing, Jianu, Radu, Ulin, Samuel P., Raphael, Benjamin J., Laidlaw, David H., Brossay, Laurent, Salomon, Arthur R.

“…Reversible protein phosphorylation plays a pivotal role in the regulation of cellular signaling pathways. Current approaches in phosphoproteomics focus on…”
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Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells by Cao, Lulu, Ding, Yiyuan, Hung, Norris, Yu, Kebing, Ritz, Anna, Raphael, Benjamin J, Salomon, Arthur R

“…The SH2-domain-containing leukocyte protein of 76 kDa (SLP-76) plays a critical scaffolding role in T cell receptor (TCR) signaling. As an adaptor protein that…”
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Profiling of Tyrosine Phosphorylation Pathways in Human Cells Using Mass Spectrometry by Salomon, Arthur R., Ficarro, Scott B., Brill, Laurence M., Brinker, Achim, Phung, Qui T., Ericson, Christer, Sauer, Karsten, Brock, Ansgar, Horn, David M., Schultz, Peter G., Peters, Eric C.

“…The reversible phosphorylation of tyrosine residues is an important mechanism for modulating biological processes such as cellular signaling, differentiation,…”
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Quantitative Time-Resolved Phosphoproteomic Analysis of Mast Cell Signaling by Cao, Lulu, Yu, Kebing, Banh, Cindy, Nguyen, Vinh, Ritz, Anna, Raphael, Benjamin J, Kawakami, Yuko, Kawakami, Toshiaki, Salomon, Arthur R

“…Mast cells play a central role in type I hypersensitivity reactions and allergic disorders such as anaphylaxis and asthma. Activation of mast cells, through a…”
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Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit by Boylan, Joan M., Salomon, Arthur R., Tantravahi, Umadevi, Gruppuso, Philip A.

“…Protein phosphatase 6 (PP6) is a ubiquitous Ser/Thr phosphatase involved in an array of cellular processes. To assess the potential of PP6 as a therapeutic…”
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New Prospects for an Old Enzyme:  Mammalian Cytochrome c Is Tyrosine-Phosphorylated in Vivo by Lee, Icksoo, Salomon, Arthur R, Yu, Kebing, Doan, Jeffrey W, Grossman, Lawrence I, Hüttemann, Maik

“…Mammalian cytochrome c (Cyt c) has two primary functions:  transfer of electrons from the bc 1 complex to cytochrome c oxidase (COX) as part of the…”
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Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT by Lo, Wan-Lin, Shah, Neel H., Ahsan, Nagib, Horkova, Veronika, Stepanek, Ondrej, Salomon, Arthur R., Kuriyan, John, Weiss, Arthur

“…T cell–antigen receptor (TCR) signaling requires the sequential activities of the kinases Lck and Zap70. Upon TCR stimulation, Lck phosphorylates the TCR, thus…”
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Deep phosphotyrosine characterisation of primary murine T cells using broad spectrum optimisation of selective triggering by Callahan, Aurora, Chua, Xien Yu, Griffith, Alijah A, Hildebrandt, Tobias, Fu, Guoping, Hu, Mengzhou, Wen, Renren, Salomon, Arthur R

“…Sequencing the tyrosine phosphoproteome using MS-based proteomics is challenging due to the low abundance of tyrosine phosphorylation in cells, a challenge…”
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SILAC Phosphoproteomics Reveals Unique Signaling Circuits in CAR‑T Cells and the Inhibition of B Cell-Activating Phosphorylation in Target Cells by Griffith, Alijah A, Callahan, Kenneth P, King, Nathan Gordo, Xiao, Qian, Su, Xiaolei, Salomon, Arthur R

“…Chimeric antigen receptor (CAR) is a single-pass transmembrane receptor designed to specifically target and eliminate cancers. While CARs prove highly…”
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SRC Homology 2 Domain-containing Leukocyte Phosphoprotein of 76 kDa (SLP-76) N-terminal Tyrosine Residues Regulate a Dynamic Signaling Equilibrium Involving Feedback of Proximal T-cell Receptor (TCR) Signaling by Ji, Qinqin, Ding, Yiyuan, Salomon, Arthur R.

“…SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) is a cytosolic adaptor protein that plays an important role in the T-cell…”
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Understanding and Exploiting the Mechanistic Basis for Selectivity of Polyketide Inhibitors of F0F1-ATPase by Salomon, Arthur R, Voehringer, David W, Herzenberg, Leonard A, Khosla, Chaitan

“…Recently, a family of polyketide inhibitors of F0F1-ATPase, including apoptolidin, ossamycin, and oligomycin, were shown to be among the top 0.1% most cell…”
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The NatA acetyltransferase couples Sup35 prion complexes to the [PSI+] phenotype by Pezza, John A, Langseth, Sara X, Raupp Yamamoto, Rochele, Doris, Stephen M, Ulin, Samuel P, Salomon, Arthur R, Serio, Tricia R

“…Protein-only (prion) epigenetic elements confer unique phenotypes by adopting alternate conformations that specify new traits. Given the conformational…”
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