Search Results - "Salomaa, Veikko"

Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort by Havulinna, Aki S, Sysi-Aho, Marko, Hilvo, Mika, Kauhanen, Dimple, Hurme, Reini, Ekroos, Kim, Salomaa, Veikko, Laaksonen, Reijo

“…OBJECTIVE—Ceramides are molecular lipids implicated in apoptosis, inflammation, obesity, and insulin resistance. An earlier study reported that ceramides were…”
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Prospects of Fine-Mapping Trait-Associated Genomic Regions by Using Summary Statistics from Genome-wide Association Studies by Benner, Christian, Havulinna, Aki S., Järvelin, Marjo-Riitta, Salomaa, Veikko, Ripatti, Samuli, Pirinen, Matti

“…During the past few years, various novel statistical methods have been developed for fine-mapping with the use of summary statistics from genome-wide…”
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FINEMAP: efficient variable selection using summary data from genome-wide association studies by Benner, Christian, Spencer, Chris C A, Havulinna, Aki S, Salomaa, Veikko, Ripatti, Samuli, Pirinen, Matti

“…The goal of fine-mapping in genomic regions associated with complex diseases and traits is to identify causal variants that point to molecular mechanisms…”
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Polygenic Risk Scores Predict Hypertension Onset and Cardiovascular Risk by Vaura, Felix, Kauko, Anni, Suvila, Karri, Havulinna, Aki S., Mars, Nina, Salomaa, Veikko, FinnGen, Cheng, Susan, Niiranen, Teemu

“…Although genetic risk scores have been used to predict hypertension, their utility in the clinical setting remains uncertain. Our study comprised N=218 792…”
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Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank by Julkunen, Heli, Cichońska, Anna, Tiainen, Mika, Koskela, Harri, Nybo, Kristian, Mäkelä, Valtteri, Nokso-Koivisto, Jussi, Kristiansson, Kati, Perola, Markus, Salomaa, Veikko, Jousilahti, Pekka, Lundqvist, Annamari, Kangas, Antti J., Soininen, Pasi, Barrett, Jeffrey C., Würtz, Peter

“…Blood lipids and metabolites are markers of current health and future disease risk. Here, we describe plasma nuclear magnetic resonance (NMR) biomarker data…”
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Taxonomic signatures of cause-specific mortality risk in human gut microbiome by Salosensaari, Aaro, Laitinen, Ville, Havulinna, Aki S., Meric, Guillaume, Cheng, Susan, Perola, Markus, Valsta, Liisa, Alfthan, Georg, Inouye, Michael, Watrous, Jeramie D., Long, Tao, Salido, Rodolfo A., Sanders, Karenina, Brennan, Caitriona, Humphrey, Gregory C., Sanders, Jon G., Jain, Mohit, Jousilahti, Pekka, Salomaa, Veikko, Knight, Rob, Lahti, Leo, Niiranen, Teemu

“…The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome…”
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Risks of Light and Moderate Alcohol Use in Fatty Liver Disease: Follow‐Up of Population Cohorts by Åberg, Fredrik, Puukka, Pauli, Salomaa, Veikko, Männistö, Satu, Lundqvist, Annamari, Valsta, Liisa, Perola, Markus, Färkkilä, Martti, Jula, Antti

“…Background and Aims The effects of alcohol use in nonalcoholic fatty liver disease are unclear. We investigated the impact of alcohol use in fatty liver…”
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Sex, Smoking, and Risk for Subarachnoid Hemorrhage by Lindbohm, Joni Valdemar, Kaprio, Jaakko, Jousilahti, Pekka, Salomaa, Veikko, Korja, Miikka

“…BACKGROUND AND PURPOSE—Women are at higher risk for subarachnoid hemorrhage (SAH) than men for unknown reasons. Also cumulative effects of smoking have been…”
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Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors by Ahola-Olli, Ari V., Würtz, Peter, Havulinna, Aki S., Aalto, Kristiina, Pitkänen, Niina, Lehtimäki, Terho, Kähönen, Mika, Lyytikäinen, Leo-Pekka, Raitoharju, Emma, Seppälä, Ilkka, Sarin, Antti-Pekka, Ripatti, Samuli, Palotie, Aarne, Perola, Markus, Viikari, Jorma S., Jalkanen, Sirpa, Maksimow, Mikael, Salomaa, Veikko, Salmi, Marko, Kettunen, Johannes, Raitakari, Olli T.

“…Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide…”
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Greengenes2 unifies microbial data in a single reference tree by McDonald, Daniel, Jiang, Yueyu, Balaban, Metin, Cantrell, Kalen, Zhu, Qiyun, Gonzalez, Antonio, Morton, James T., Nicolaou, Giorgia, Parks, Donovan H., Karst, Søren M., Albertsen, Mads, Hugenholtz, Philip, DeSantis, Todd, Song, Se Jin, Bartko, Andrew, Havulinna, Aki S., Jousilahti, Pekka, Cheng, Susan, Inouye, Michael, Niiranen, Teemu, Jain, Mohit, Salomaa, Veikko, Lahti, Leo, Mirarab, Siavash, Knight, Rob

“…Studies using 16S rRNA and shotgun metagenomics typically yield different results, usually attributed to PCR amplification biases. We introduce Greengenes2, a…”
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A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals by Deelen, Joris, Kettunen, Johannes, Fischer, Krista, van der Spek, Ashley, Trompet, Stella, Kastenmüller, Gabi, Boyd, Andy, Zierer, Jonas, van den Akker, Erik B., Ala-Korpela, Mika, Amin, Najaf, Demirkan, Ayse, Ghanbari, Mohsen, van Heemst, Diana, Ikram, M. Arfan, van Klinken, Jan Bert, Mooijaart, Simon P., Peters, Annette, Salomaa, Veikko, Sattar, Naveed, Spector, Tim D., Tiemeier, Henning, Verhoeven, Aswin, Waldenberger, Melanie, Würtz, Peter, Davey Smith, George, Metspalu, Andres, Perola, Markus, Menni, Cristina, Geleijnse, Johanna M., Drenos, Fotios, Beekman, Marian, Jukema, J. Wouter, van Duijn, Cornelia M., Slagboom, P. Eline

“…Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics…”
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Genomic prediction of coronary heart disease by Abraham, Gad, Havulinna, Aki S, Bhalala, Oneil G, Byars, Sean G, De Livera, Alysha M, Yetukuri, Laxman, Tikkanen, Emmi, Perola, Markus, Schunkert, Heribert, Sijbrands, Eric J, Palotie, Aarno, Samani, Nilesh J, Salomaa, Veikko, Ripatti, Samuli, Inouye, Michael

“…Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of genomic risk scores (GRSs) relative to clinical risk scores, such…”
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Genetic Risk Prediction and a 2-Stage Risk Screening Strategy for Coronary Heart Disease by Tikkanen, Emmi, Havulinna, Aki S., Palotie, Aarno, Salomaa, Veikko, Ripatti, Samuli

“…OBJECTIVE—Genome-wide association studies have identified several genetic variants associated with coronary heart disease (CHD). The aim of this study was to…”
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Genetic Associations of Chronotype in the Finnish General Population by Maukonen, Mirkka, Havulinna, Aki S., Männistö, Satu, Kanerva, Noora, Salomaa, Veikko, Partonen, Timo

“…Individuals with a later chronotype (evening types) tend to have unhealthier behaviors and increased morbidity and mortality as compared with those with an…”
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Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent by Buchwald, Jadwiga, Chenoweth, Meghan J., Palviainen, Teemu, Zhu, Gu, Benner, Christian, Gordon, Scott, Korhonen, Tellervo, Ripatti, Samuli, Madden, Pamela A. F., Lehtimäki, Terho, Raitakari, Olli T., Salomaa, Veikko, Rose, Richard J., George, Tony P., Lerman, Caryn, Pirinen, Matti, Martin, Nicholas G., Kaprio, Jaakko, Loukola, Anu, Tyndale, Rachel F.

“…Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are altered by the rate of nicotine clearance. Nicotine clearance…”
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Risk Factors of Sudden Death From Subarachnoid Hemorrhage by Lindbohm, Joni Valdemar, Kaprio, Jaakko, Jousilahti, Pekka, Salomaa, Veikko, Korja, Miikka

“…BACKGROUND AND PURPOSE—One in every 4 subarachnoid hemorrhage (SAH) patients dies suddenly outside hospital, but most SAH risk factor studies focus on…”
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Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes by Csengeri, Dora, Sprünker, Ngoc-Anh, Di Castelnuovo, Augusto, Niiranen, Teemu, Vishram-Nielsen, Julie Kk, Costanzo, Simona, Söderberg, Stefan, Jensen, Steen M, Vartiainen, Erkki, Donati, Maria Benedetta, Magnussen, Christina, Camen, Stephan, Gianfagna, Francesco, Løchen, Maja-Lisa, Kee, Frank, Kontto, Jukka, Mathiesen, Ellisiv B, Koenig, Wolfgang, Blankenberg, Stefan, de Gaetano, Giovanni, Jørgensen, Torben, Kuulasmaa, Kari, Zeller, Tanja, Salomaa, Veikko, Iacoviello, Licia, Schnabel, Renate B

“…Abstract Aims  There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We…”
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Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland by Kerminen, Sini, Martin, Alicia R., Koskela, Jukka, Ruotsalainen, Sanni E., Havulinna, Aki S., Surakka, Ida, Palotie, Aarno, Perola, Markus, Salomaa, Veikko, Daly, Mark J., Ripatti, Samuli, Pirinen, Matti

“…Polygenic scores (PSs) are becoming a useful tool to identify individuals with high genetic risk for complex diseases, and several projects are currently…”
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Associations of healthy food choices with gut microbiota profiles by Koponen, Kari K, Salosensaari, Aaro, Ruuskanen, Matti O, Havulinna, Aki S, Männistö, Satu, Jousilahti, Pekka, Palmu, Joonatan, Salido, Rodolfo, Sanders, Karenina, Brennan, Caitriona, Humphrey, Gregory C, Sanders, Jon G, Meric, Guillaume, Cheng, Susan, Inouye, Michael, Jain, Mohit, Niiranen, Teemu J, Valsta, Liisa M, Knight, Rob, Salomaa, Veikko V

“…Diet has a major influence on the human gut microbiota, which has been linked to health and disease. However, epidemiological studies on associations of a…”
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Twenty-five-year trends in myocardial infarction attack and mortality rates, and case-fatality, in six European populations by Dégano, Irene R, Salomaa, Veikko, Veronesi, Giovanni, Ferriéres, Jean, Kirchberger, Inge, Laks, Toivo, Havulinna, Aki S, Ruidavets, Jean-Bernard, Ferrario, Marco M, Meisinger, Christa, Elosua, Roberto, Marrugat, Jaume

“…Due to the burden of coronary heart disease (CHD), the monitoring of CHD trends is required. This study sought to examine the acute myocardial infarction (AMI)…”
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