Search Results - "Salom, Juan B."

Cerebroprotective Effect of 17β-Estradiol Replacement Therapy in Ovariectomy-Induced Post-Menopausal Rats Subjected to Ischemic Stroke: Role of MAPK/ERK1/2 Pathway and PI3K-Independent Akt Activation by Burguete, María C, Jover-Mengual, Teresa, Castelló-Ruiz, María, López-Morales, Mikahela A, Centeno, José M, Aliena-Valero, Alicia, Alborch, Enrique, Torregrosa, Germán, Salom, Juan B

“…Despite the overwhelming advances in the understanding of the pathogenesis of stroke, a devastating disease affecting millions of people worldwide, currently…”
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The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia by Vecino, Rebeca, Burguete, Maria C., Jover-Mengual, Teresa, Agulla, Jesus, Bobo-Jiménez, Verónica, Salom, Juan B., Almeida, Angeles, Delgado-Esteban, Maria

“…Brain preconditioning (PC) refers to a state of transient tolerance against a lethal insult that can be evoked by a prior mild event. It is thought that PC may…”
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Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage by DeGregorio-Rocasolano, Nuria, Martí-Sistac, Octavi, Ponce, Jovita, Castelló-Ruiz, María, Millán, Mònica, Guirao, Verónica, García-Yébenes, Isaac, Salom, Juan B., Ramos-Cabrer, Pedro, Alborch, Enrique, Lizasoain, Ignacio, Castillo, José, Dávalos, Antoni, Gasull, Teresa

“…Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through…”
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Cerebroprotective Effects of the TLR4-Binding DNA Aptamer ApTOLL in a Rat Model of Ischemic Stroke and Thrombectomy Recanalization by Aliena-Valero, Alicia, Hernández-Jiménez, Macarena, López-Morales, Mikahela A, Tamayo-Torres, Eva, Castelló-Ruiz, María, Piñeiro, David, Ribó, Marc, Salom, Juan B

“…ApTOLL, a TLR4 modulator aptamer, has demonstrated cerebroprotective effects in a permanent ischemic stroke mouse model, as well as safety and efficacy in…”
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Clot Composition Analysis as a Diagnostic Tool to Gain Insight into Ischemic Stroke Etiology: A Systematic Review by Aliena-Valero, Alicia, Baixauli-Martín, Júlia, Torregrosa, Germán, Tembl, José I, Salom, Juan B

“…Mechanical thrombectomy renders the occluding clot available for analysis. Insights into thrombus composition could help establish the stroke cause. We aimed…”
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Functional Recovery and Serum Angiogenin Changes According to Intensity of Rehabilitation Therapy After Stroke by Garcia-Rodriguez, Nicolás, Rodriguez, Susana, Tejada, Pedro Ignacio, Miranda-Artieda, Zuberoa Maite, Ridao, Natalia, Buxó, Xavi, Pérez-Mesquida, María Engracia, Beseler, Maria Rosario, Salom, Juan B, Pérez, Laura M, Inzitari, Marco, Otero-Villaverde, Sergio, Martin-Mourelle, Rosa, Molleda, Mercedes, Quintana, Manuel, Olivé-Gadea, Marta, Penalba, Anna, Rosell, Anna

“…Rehabilitation is still the only treatment available to improve functional status after the acute phase of stroke. Most clinical guidelines highlight the need…”
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Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke by Martínez-Alonso, Emma, Escobar-Peso, Alejandro, Aliena-Valero, Alicia, Torregrosa, Germán, Chioua, Mourad, Fernández-Serra, Rocío, González-Nieto, Daniel, Ouahid, Youness, Salom, Juan B., Masjuan, Jaime, Marco-Contelles, José, Alcázar, Alberto

“…Nitrones are encouraging drug candidates for the treatment of oxidative stress-driven diseases such as acute ischemic stroke (AIS). In a previous study, we…”
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Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation by DeGregorio-Rocasolano, Núria, Guirao, Verónica, Ponce, Jovita, Melià-Sorolla, Marc, Aliena-Valero, Alicia, García-Serran, Alexia, Salom, Juan B, Dávalos, Antoni, Martí-Sistac, Octavi, Gasull, Teresa

“…Death-associated protein kinase 1 (DAPK1) is a pleiotropic hub of a number of networked distributed intracellular processes. Among them, DAPK1 is known to…”
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Neutrophil extracellular traps are increased in patients with acute ischemic stroke: prognostic significance by Vallés, Juana, Lago, Aída, Santos, María Teresa, Latorre, Ana María, Tembl, José I, Salom, Juan B, Nieves, Candela, Moscardó, Antonio

“…Neutrophil extracellular traps (NETs) are networks of DNA, histones, and proteolytic enzymes produced by activated neutrophils through different mechanisms…”
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Dietary phytoestrogens improve stroke outcome after transient focal cerebral ischemia in rats by Burguete, María C., Torregrosa Pérez-Asensio, Germán, Fernando J., Castelló-Ruiz, María, Salom Gil, Juan B., José V., Alborch, Enrique

“…As phytoestrogens are postulated as being neuroprotectants, we assessed the hypothesis that dietary isoflavone‐type phytoestrogens are neuroprotective against…”
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Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia by Pérez-Asensio, Fernando J., Hurtado, Olivia, Burguete, María C., Moro, María A., Salom, Juan B., Lizasoain, Ignacio, Torregrosa, Germán, Leza, Juan C., Alborch, Enrique, Castillo, José, Knowles, Richard G., Lorenzo, Pedro

“…Background and purpose. It has been shown that the reversed operation of glutamate transporters when ATP levels fall accounts for most glutamate release…”
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Diabetes impairs the atrial natriuretic peptide relaxant action mediated by potassium channels and prostacyclin in the rabbit renal artery by Marrachelli, Vannina G., Centeno, José M., Miranda, Ignacio, Castelló-Ruiz, María, Burguete, María C., Jover-Mengual, Teresa, Salom, Juan B., Torregrosa, Germán, Miranda, Francisco J., Alborch, Enrique

“…Diabetes is associated with increased prevalence of hypertension, cardiovascular and renal disease. Atrial natriuretic peptide (ANP) plays an important role in…”
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Effect of uric acid in animal models of ischemic stroke: A systematic review and meta-analysis by Aliena-Valero, Alicia, Baixauli-Martín, Júlia, Castelló-Ruiz, María, Torregrosa, Germán, Hervás, David, Salom, Juan B

“…Addition of uric acid (UA) to thrombolytic therapy, although safe, showed limited efficacy in improving patients’ stroke outcome, despite alleged…”
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Mechanisms underlying the diabetes-induced hyporeactivity of the rabbit carotid artery to atrial natriuretic peptide by Marrachelli, Vannina G., Miranda, Francisco J., Centeno, José M., Miranda, Ignacio, Castelló-Ruiz, María, Burguete, María C., Jover-Mengual, Teresa, Salom, Juan B., Torregrosa, Germán, Alborch, Enrique

“…Atrial natriuretic peptide (ANP) plays an important role in the pathophysiology of the vascular complications in diabetes. The working hypothesis was that…”
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Brain Cell Senescence: A New Therapeutic Target for the Acute Treatment of Ischemic Stroke by Baixauli-Martín, Júlia, Aliena-Valero, Alicia, Castelló-Ruiz, María, Burguete, María C, López-Morales, Mikahela A, Muñoz-Espín, Daniel, Torregrosa, Germán, Salom, Juan B

“…Abstract Aging is a major risk factor for cerebral infarction. Since cellular senescence is intrinsic to aging, we postulated that stroke-induced cellular…”
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Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis by López-Morales, Mikahela A, Castelló-Ruiz, María, Burguete, María C, Hervás, David, Pérez-Pinzón, Miguel A, Salom, Juan B

“…Resveratrol (RSV) holds promise as cerebroprotective treatment in cerebral ischemia. This systematic review aims to assess the effects and mechanisms of RSV in…”
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Novel Antihypertensive Lactoferrin-Derived Peptides Produced by Kluyveromyces marxianus: Gastrointestinal Stability Profile and In Vivo Angiotensin I‑Converting Enzyme (ACE) Inhibition by García-Tejedor, Aurora, Sánchez-Rivera, Laura, Castelló-Ruiz, María, Recio, Isidra, Salom, Juan B, Manzanares, Paloma

“…Novel antihypertensive peptides released by Kluyveromyces marxianus from bovine lactoferrin (LF) have been identified. K. marxianus LF permeate was…”
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Uric Acid Neuroprotection Associated to IL-6/STAT3 Signaling Pathway Activation in Rat Ischemic Stroke by Aliena-Valero, Alicia, Rius-Pérez, Sergio, Baixauli-Martín, Júlia, Torregrosa, Germán, Chamorro, Ángel, Pérez, Salvador, Salom, Juan B.

“…Despite the promising neuroprotective effects of uric acid (UA) in acute ischemic stroke, the seemingly pleiotropic underlying mechanisms are not completely…”
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Optimised lyophilisation-based method for different biomolecule single-extractions from the same rat brain sample: Suitability for RNA and protein expression analyses after ischemic stroke by Aliena-Valero, Alicia, Rius-Pérez, Sergio, Pérez, Salvador, Torregrosa, Germán, Salom, Juan B.

“…•A lyophilisation-based method to obtain rat brain tissue powder was developed.•Different biomolecule specialist single-extractions can be carried out in…”
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Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats by Aliena-Valero, Alicia, López-Morales, Mikahela A., Burguete, María C., Castelló-Ruiz, María, Jover-Mengual, Teresa, Hervás, David, Torregrosa, Germán, Leira, Enrique C., Chamorro, Ángel, Salom, Juan B.

“…[Display omitted] •The effects of uric acid in an ischemic stroke model relevant to mechanical thrombectomy treatment were assessed.•At 24 h after stroke,…”
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