Search Results - "Salnikov, Alexei V"

Therapeutic Potential of Amanitin-Conjugated Anti-Epithelial Cell Adhesion Molecule Monoclonal Antibody Against Pancreatic Carcinoma by MOLDENHAUER, Gerhard, SALNIKOV, Alexei V, LÜTTGAU, Sandra, HERR, Ingrid, ANDERL, Jan, FAULSTICH, Heinz

“…Human epithelial cell adhesion molecule (EpCAM) is overexpressed in many cancers. Anti-EpCAM antibodies have shown promise in preclinical studies, but showed…”
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Synergistic Activity of Sorafenib and Sulforaphane Abolishes Pancreatic Cancer Stem Cell Characteristics by RAUSCH, Vanessa, LI LIU, SALNIKOV, Alexei V, HERR, Ingrid, KALLIFATIDIS, Georgios, BAUMANN, Bernd, MATTERN, Jürgen, GLADKICH, Jury, WIRTH, Thomas, SCHEMMER, Peter, BÜCHLER, Markus W, ZÖLLER, Margot

“…Recent evidence suggests that pancreatic cancer and other solid tumors contain a subset of tumorigenic cells capable of extensive self-renewal that contribute…”
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Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential by Salnikov, Alexei V, Liu, Li, Platen, Mitja, Gladkich, Jury, Salnikova, Olga, Ryschich, Eduard, Mattern, Jürgen, Moldenhauer, Gerhard, Werner, Jens, Schemmer, Peter, Büchler, Markus W, Herr, Ingrid

“…Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT…”
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CD24 controls Src/STAT3 activity in human tumors by Bretz, Niko P., Salnikov, Alexei V., Perne, Claudia, Keller, Sascha, Wang, Xiaoli, Mierke, Claudia T., Fogel, Mina, Erbe-Hofmann, Natalie, Schlange, Thomas, Moldenhauer, Gerhard, Altevogt, Peter

“…CD24 is a glycosyl-phosphatidylinositol-anchored membrane protein that is frequently over-expressed in a variety of human carcinomas and is correlated with…”
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Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma by Oldberg, Åke, Kalamajski, Sebastian, Salnikov, Alexei V, Stuhr, Linda, Mörgelin, Matthias, Reed, Rolf K, Heldin, Nils-Erik, Rubin, Kristofer

“…Research on the biology of the tumor stroma has the potential to lead to development of more effective treatment regimes enhancing the efficacy of drug-based…”
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Inhibition of integrin αVβ6 changes fibril thickness of stromal collagen in experimental carcinomas by Olof Olsson, P., Gustafsson, Renata, Salnikov, Alexei V., Göthe, Maria, Zeller, Kathrin S., Friman, Tomas, Baldetorp, Bo, Koopman, Louise A., Weinreb, Paul H., Violette, Shelia M., Kalamajski, Sebastian, Heldin, Nils-Erik, Rubin, Kristofer

“…BackgroundChemotherapeutic efficacy can be improved by targeting the structure and function of the extracellular matrix (ECM) in the carcinomal stroma. This…”
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Inhibition of carcinoma cell‐derived VEGF reduces inflammatory characteristics in xenograft carcinoma by Salnikov, Alexei V., Heldin, Nils‐Erik, Stuhr, Linda B., Wiig, Helge, Gerber, Hanspeter, Reed, Rolf K., Rubin, Kristofer

“…The stroma of carcinomas shares several characteristics with inflamed tissues including a distorted vasculature, active angiogenesis and macrophage…”
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Triptolide reverses hypoxia‐induced epithelial–mesenchymal transition and stem‐like features in pancreatic cancer by NF‐κB downregulation by Liu, Li, Salnikov, Alexei V., Bauer, Nathalie, Aleksandrowicz, Ewa, Labsch, Sabrina, Nwaeburu, Clifford, Mattern, Jürgen, Gladkich, Jury, Schemmer, Peter, Werner, Jens, Herr, Ingrid

“…Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies characterized by an intense tumor stroma with hypoperfused regions, a significant…”
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CD133 is indicative for a resistance phenotype but does not represent a prognostic marker for survival of non‐small cell lung cancer patients by Salnikov, Alexei V., Gladkich, Jury, Moldenhauer, Gerhard, Volm, Manfred, Mattern, Jürgen, Herr, Ingrid

“…Despite advances in anticancer treatment, lung cancer still has poor prognosis. Recently, a cancer stem cell (CSC) hypothesis has emerged describing a small…”
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Sulforaphane Increases Drug-mediated Cytotoxicity Toward Cancer Stem-like Cells of Pancreas and Prostate by Kallifatidis, Georgios, Labsch, Sabrina, Rausch, Vanessa, Mattern, Juergen, Gladkich, Jury, Moldenhauer, Gerhard, Büchler, Markus W., Salnikov, Alexei V., Herr, Ingrid

“…Despite intense efforts to develop treatments against pancreatic cancer, agents that cure this highly resistant and metastasizing disease are not available…”
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Combining forces to hit cancer stem cells: TRAIL-lymphocytes and EpCAMxCD3 bispecific antibody show efficacy against pancreatic cancer by Herr, Ingrid, Groth, Ariane, Salnikov, Alexei V., Buchler, Markus W., Moldenhauer, Gerhard

“…TRAIL selectively kills cancer cells while bispecific antibody EpCAMxCD3 guides effector lymphocytes to cancer cells. Arming of ex vivo constructed…”
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Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment by Rausch, Vanessa, Liu, Li, Apel, Anja, Rettig, Theresa, Gladkich, Jury, Labsch, Sabrina, Kallifatidis, Georgios, Kaczorowski, Adam, Groth, Ariane, Gross, Wolfgang, Gebhard, Martha M, Schemmer, Peter, Werner, Jens, Salnikov, Alexei V, Zentgraf, Hanswalter, Büchler, Markus W, Herr, Ingrid

“…Involvement of dysregulated autophagy in cancer growth and progression has been shown in different tumour entities, including pancreatic ductal adenocarcinoma…”
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Dietary polyphenol quercetin targets pancreatic cancer stem cells by WEI ZHOU, KALLIFATIDLS, Georgios, SALNIKOV, Alexei V, HERR, Ingrid, BAUMANN, Bernd, RAUSCH, Vanessa, MATTERN, Jürgen, GLADKICH, Jury, GIESE, Nathalia, MOLDENHAUER, Gerhard, WIRTH, Thomas, BÜCHLER, Markus W

“…According to the cancer stem cell hypothesis the aggressive growth and early metastasis of pancreatic cancer may arise through dysregulation of self-renewal of…”
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CD24 promotes tumor cell invasion by suppressing tissue factor pathway inhibitor-2 (TFPI-2) in a c-Src-dependent fashion by Bretz, Niko, Noske, Aurelia, Keller, Sascha, Erbe-Hofmann, Natalie, Schlange, Thomas, Salnikov, Alexei V., Moldenhauer, Gerd, Kristiansen, Glen, Altevogt, Peter

“…CD24 is a glycosyl-phosphatidylinositol-anchored protein with mucin-type structure that resides exclusively in membrane microdomains. CD24 is often highly…”
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Expression and properties of the glyoxysomal and cytosolic forms of isocitrate lyase in Amaranthus caudatus L by Eprintsev, Alexander T., Fedorin, Dmitry N., Salnikov, Alexei V., Igamberdiev, Abir U.

“…Isocitrate lyase (EC 4.1.3.1) catalyzes the reversible conversion of d-isocitrate to succinate and glyoxylate. It is usually associated with the glyoxylate…”
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Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter by Salnikov, Alexei V, Kusumawidjaja, Grace, Rausch, Vanessa, Bruns, Helge, Gross, Wolfgang, Khamidjanov, Akmal, Ryschich, Eduard, Gebhard, Martha-Maria, Moldenhauer, Gerhard, Büchler, Markus W, Schemmer, Peter, Herr, Ingrid

“…Abstract Recent findings suggest that the presence of cancer stem cells could be linked with patients’ survival. We profiled suggested cancer stem cell markers…”
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Targeting of cancer stem cell marker EpCAM by bispecific antibody EpCAMxCD3 inhibits pancreatic carcinoma by Salnikov, Alexei V., Groth, Ariane, Apel, Anja, Kallifatidis, Georgios, Beckermann, Benjamin M., Khamidjanov, Akmal, Ryschich, Eduard, Büchler, Markus W., Herr, Ingrid, Moldenhauer, Gerhard

“…Patients with pancreatic cancer have a poor survival rate, and new therapeutic strategies are needed. Epithelial cell adhesion molecule (EpCAM), suggested as a…”
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New Gene-Immunotherapy Combining TRAIL-Lymphocytes and EpCAMxCD3 Bispecific Antibody for Tumor Targeting by GROTH, Ariane, SALNIKOV, Alexei V, MOMBURG, Frank, BÜCHLER, Markus W, MOLDENHAUER, Gerhard, HERR, Ingrid, OTTINGER, Sabine, GLADKICH, Jury, LI LIU, KALLIFATIDIS, Georgios, SALNIKOVA, Olga, RYSCHICH, Eduard, GIESE, Nathalia, GIESE, Thomas

“…To enhance T-cell responsiveness toward cancer cells, we overexpressed TRAIL in lymphocytes, as this death ligand induces tumor-specific apoptosis. To increase…”
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Lack of CD24 expression in mice reduces the number of leukocytes in the colon by Bretz, Niko P, Salnikov, Alexei V, Doberstein, Kai, Garbi, Natalio, Kloess, Volker, Joumaa, Safwan, Naumov, Inna, Boon, Louis, Moldenhauer, Gerhard, Arber, Nadir, Altevogt, Peter

“…Highlights • We compared leukocytes in organs of CD24−/− vs. wildtype mice. • Highly decreased numbers of leukocytes in colons of CD24−/− mice were detected. •…”
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Mo1802 Role of CD24 in the Development of DSS-Induced Murine Experimental Colitis by Naumov, Inna, Kraus, Sarah, Shapira, Shiran, Aroch, Ilan, Kazanov, Diana, Ron, Ehud, Gitstein, Gilad, Elinav, Eran, Salnikov, Alexei V, Altevogt, Peter, Arber, Nadir

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