Search Results - "Salmond, Robert J."

mTOR Regulation of Glycolytic Metabolism in T Cells by Salmond, Robert J

“…T cell activation, differentiation and effector function is intrinsically linked to the regulation of metabolic pathways. Evidence has shown that inflammatory…”
Get full text

Type 2 innate lymphoid cells drive CD4+ Th2 cell responses by Mirchandani, Ananda S, Besnard, Anne-Gaelle, Yip, Edwin, Scott, Charlotte, Bain, Calum C, Cerovic, Vuk, Salmond, Robert J, Liew, Foo Y

“…CD4(+) T cells have long been grouped into distinct helper subsets on the basis of their cytokine-secretion profile. In recent years, several subsets of innate…”
Get full text

Regulation of T Cell Activation and Metabolism by Transforming Growth Factor-Beta by Salmond, Robert J

“…Transforming growth factor beta (TGFβ) receptor signalling regulates T cell development, differentiation and effector function. Expression of the…”
Get full text

Targeting Protein Tyrosine Phosphatases to Improve Cancer Immunotherapies by Salmond, Robert J

“…Advances in immunotherapy have brought significant therapeutic benefits to many cancer patients. Nonetheless, many cancer types are refractory to current…”
Get full text

Interleukin-33 and the function of innate lymphoid cells by Mirchandani, Ananda S, Salmond, Robert J, Liew, Foo Y

“…Interleukin (IL)-33 is a member of the IL-1 cytokine family that has been shown to play an important role in the induction and effector phases of type 2 immune…”
Get full text

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals by Salmond, Robert J, Brownlie, Rebecca J, Morrison, Vicky L, Zamoyska, Rose

“…The phosphatase PTPN22 is associated with human autoimmune disease. Zamoyska and colleagues demonstrate that loss of PTPN22 enhances T cell responses to weak…”
Get full text

IL-33 induces innate lymphoid cell–mediated airway inflammation by activating mammalian target of rapamycin by Salmond, Robert J., PhD, Mirchandani, Ananda S., MBChB, Besnard, Anne-Gaelle, PhD, Bain, Calum C., BSc, Thomson, Neil C., MD, Liew, Foo Y., PhD

“…Background The IL-1 family cytokine IL-33 is involved in the induction of airway inflammation in allergic patients and after viral infection. Several cell…”
Get full text

Editorial: Understanding how myeloid cell development and function meet tissue distinct metabolic requirements by Palmieri, Erika M, Salmond, Robert J, Menga, Alessio

Get full text

Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22 by Brownlie, Rebecca J., Garcia, Celine, Ravasz, Mate, Zehn, Dietmar, Salmond, Robert J., Zamoyska, Rose

“…Transforming growth factor β (TGFβ) is important in maintaining self-tolerance and inhibits T cell reactivity. We show that CD8 + T cells that lack the…”
Get full text

TGFβ limits Myc-dependent TCR-induced metabolic reprogramming in CD8 + T cells by Hope, Helen Carrasco, Pickersgill, Gabriella, Ginefra, Pierpaolo, Vannini, Nicola, Cook, Graham P, Salmond, Robert J

“…T cell activation is dependent upon the integration of antigenic, co-stimulatory and cytokine-derived signals and the availability and acquisition of nutrients…”
Get full text

Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice by Sood, Shatakshi, Brownlie, Rebecca J, Garcia, Celine, Cowan, Graeme, Salmond, Robert J, Sakaguchi, Shimon, Zamoyska, Rose

“…The cytoplasmic phosphatase, protein tyrosine phosphatase nonreceptor type 22 (PTPN22), is a negative regulator of T cell signaling. Genome-wide association…”
Get full text

Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation by Hope, Helen Carrasco, Brownlie, Rebecca J, Fife, Christopher M, Steele, Lynette, Lorger, Mihaela, Salmond, Robert J

“…T cell receptor (TCR) triggering by antigen results in metabolic reprogramming that, in turn, facilitates the exit of T cells from quiescence. The increased…”
Get full text

Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion by Teagle, Alexandra Rose, Castro-Sanchez, Patricia, Brownlie, Rebecca J, Logan, Nicola, Kapoor, Simran S, Wright, David, Salmond, Robert J, Zamoyska, Rose

“…BackgroundAdoptive cell therapy (ACT) is a promising strategy for treating cancer, yet it faces several challenges such as lack of long-term protection due to…”
Get full text

Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model by Andreou, Tereza, Williams, Jennifer, Brownlie, Rebecca J, Salmond, Robert J, Watson, Erica, Shaw, Gary, Melcher, Alan, Wurdak, Heiko, Short, Susan C, Lorger, Mihaela

“…Patients with glioblastoma (GBM) have a poor prognosis, and inefficient delivery of drugs to tumors represents a major therapeutic hurdle. Hematopoietic stem…”
Get full text

Unleashing T cell responses to cancer through removal of intracellular checkpoints by Salmond, Robert J

“…In a new study, researchers identified protein tyrosine phosphatase PTP1B as an inhibitor of cytokine receptor signalling and demonstrated that blocking…”
Get full text

How does the mammalian target of rapamycin (mTOR) influence CD8 T-cell differentiation? by Salmond, Robert J., Zamoyska, Rose

“…Naive T lymphocytes maintain a quiescent resting state until they encounter antigen whereupon they undergo a switch in their metabolic program in preparation…”
Get full text

Regulation of T Cell Signaling and Immune Responses by PTPN22 by Brownlie, Rebecca J, Salmond, Robert J

“…Protein tyrosine phosphatases (PTPs) play central roles in the regulation of cell signaling, organismal development, cellular differentiation and…”
Get more information

Anti–PD-1/anti–CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8⁺ T cell trafficking by Taggart, David, Andreou, Tereza, Scott, Karen J., Williams, Jennifer, Rippaus, Nora, Brownlie, Rebecca J., Ilett, Elizabeth J., Salmond, Robert J., Melcher, Alan, Lorger, Mihaela

“…Inhibition of immune checkpoints programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells results in durable antitumor…”
Get full text

Targeting the tumor microenvironment and T cell metabolism for effective cancer immunotherapy by Hope, Helen Carrasco, Salmond, Robert J.

“…The successful implementation of immunotherapies has provided new impetus in the fight against cancer. Antibody‐mediated blockade of immune checkpoint…”
Get full text

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance by Salmond, Robert J, Filby, Andrew, Qureshi, Ihjaaz, Caserta, Stefano, Zamoyska, Rose

“…T-cell development in the thymus and activation of mature T cells in secondary lymphoid organs requires the ability of cells to respond appropriately to…”
Get full text