Search Results - "Salmon, David P"
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Alzheimer's Disease: Past, Present, and Future
Published in Journal of the International Neuropsychological Society (01-10-2017)“…Although dementia has been described in ancient texts over many centuries (e.g., "Be kind to your father, even if his mind fail him." - Old Testament: Sirach…”
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The A4 study: stopping AD before symptoms begin?
Published in Science translational medicine (19-03-2014)“…A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer's disease dementia should provide insights into whether…”
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Neuropsychological Assessment of Dementia
Published in Annual review of psychology (2009)“…Neuropsychological studies show that cognitive deficits associated with Alzheimer's disease (AD) are distinct from age-associated cognitive decline…”
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Plasma biomarkers for Alzheimer’s Disease in relation to neuropathology and cognitive change
Published in Acta neuropathologica (01-04-2022)“…Plasma biomarkers related to amyloid, tau, and neurodegeneration (ATN) show great promise for identifying these pathological features of Alzheimer’s Disease…”
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Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment
Published in Journal of the International Neuropsychological Society (01-09-2014)“…Subjective cognitive complaints are a criterion for the diagnosis of mild cognitive impairment (MCI), despite their uncertain relationship to objective memory…”
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Early versus late MCI: Improved MCI staging using a neuropsychological approach
Published in Alzheimer's & dementia (01-05-2019)“…The Alzheimer's Disease Neuroimaging Initiative (ADNI) separates “early” and “late” mild cognitive impairment (MCI) based on a single memory test. We compared…”
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Effect of Knowledge of APOE Genotype on Subjective and Objective Memory Performance in Healthy Older Adults
Published in The American journal of psychiatry (01-02-2014)“…Older adults who know they have the e4 allele of the apolipoprotein E (APOE) gene, a risk factor for Alzheimer’s disease, perform worse on objective tests of…”
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Quantification of Five Neuropsychological Approaches to Defining Mild Cognitive Impairment
Published in The American journal of geriatric psychiatry (01-05-2009)“…Objectives: Operational definitions of cognitive impairment have varied widely in diagnosing mild cognitive impairment (MCI). Identifying clinical subtypes of…”
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Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors
Published in Alzheimer's & dementia (01-04-2015)“…Abstract Background We assessed whether mild cognitive impairment (MCI) subtypes could be empirically derived within the Alzheimer's Disease Neuroimaging…”
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TDP‐43 Pathology Exacerbates Cognitive Decline in Primary Age‐Related Tauopathy
Published in Annals of neurology (01-09-2022)“…Objective Primary age‐related tauopathy (PART) refers to tau neurofibrillary tangles restricted largely to the medial temporal lobe in the absence of…”
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A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease
Published in Alzheimer's & dementia (01-09-2014)“…Abstract Background Nerve growth factor (NGF) is an endogenous neurotrophic-factor protein with the potential to restore function and to protect degenerating…”
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Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults
Published in JAMA neurology (01-05-2015)“…Increased pulse pressure associated with age-related arterial stiffening increases risk for Alzheimer dementia but the mechanism responsible for this…”
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Improving dementia care: The role of screening and detection of cognitive impairment
Published in Alzheimer's & dementia (01-03-2013)“…Abstract The value of screening for cognitive impairment, including dementia and Alzheimer's disease, has been debated for decades. Recent research on causes…”
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Specific measures of executive function predict cognitive decline in older adults
Published in Journal of the International Neuropsychological Society (01-01-2012)“…Decline in executive function has been noted in the prodromal stage of Alzheimer's disease (AD) and may presage more global cognitive declines. In this…”
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Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease
Published in Alzheimer's & dementia (01-04-2015)“…Abstract We examined the relationships of antemortem vascular risk factors to postmortem cerebrovascular and Alzheimer's disease (AD) pathologies. Eighty-four…”
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Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam)
Published in PloS one (29-05-2024)“…Benfotiamine provides an important novel therapeutic direction in Alzheimer's disease (AD) with possible additive or synergistic effects to amyloid targeting…”
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Effects of Chronic Stress on Memory Decline in Cognitively Normal and Mildly Impaired Older Adults
Published in The American journal of psychiatry (01-12-2009)“…Objective: The literature provides evidence of a strong relationship between greater stress and memory loss, but few studies have examined this relationship…”
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A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Published in Nature medicine (01-05-2005)“…Cholinergic neuron loss is a cardinal feature of Alzheimer disease. Nerve growth factor (NGF) stimulates cholinergic function, improves memory and prevents…”
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What Causes the Bilingual Disadvantage in Verbal Fluency? The Dual-Task Analogy
Published in Bilingualism (Cambridge, England) (01-04-2010)“…We investigated the consequences of bilingualism for verbal fluency by comparing bilinguals to monolinguals, and dominant versus non-dominant-language fluency…”
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Artificially low mild cognitive impairment to normal reversion rate in the Alzheimer's Disease Neuroimaging Initiative
Published in Alzheimer's & dementia (01-04-2019)“…We examined reasons for low mild cognitive impairment (MCI)-to-cognitively normal (CN) reversion rates in the Alzheimer's Disease Neuroimaging Initiative…”
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