Search Results - "Salminen, William F"

Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children by Yang, Xi, Salminen, William F., Shi, Qiang, Greenhaw, James, Gill, Pritmohinder S., Bhattacharyya, Sudeepa, Beger, Richard D., Mendrick, Donna L., Mattes, William B., James, Laura P.

“…Developing biomarkers for detecting acetaminophen (APAP) toxicity has been widely investigated. Recent studies of adults with APAP-induced liver injury have…”
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Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice by Lu, Yihong, Sun, Jinchun, Petrova, Katya, Yang, Xi, Greenhaw, James, Salminen, William F., Beger, Richard D., Schnackenberg, Laura K.

“…•The interaction between GTE and APAP is complex and effects depend on the relative timing of the GTE and APAP doses.•GTE prior to APAP decreased severity of…”
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Green tea extract can potentiate acetaminophen-induced hepatotoxicity in mice by Salminen, William F., Yang, Xi, Shi, Qiang, Greenhaw, James, Davis, Kelly, Ali, Akhtar A.

“…► Green tea extract exposure before APAP reduced hepatotoxicity. ► Green tea extract exposure after APAP potentiated hepatotoxicity. ► Green tea extract…”
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Proteomic analysis of acetaminophen‐induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury by Gao, Yuan, Cao, Zhijun, Yang, Xi, Abdelmegeed, Mohamed A., Sun, Jinchun, Chen, Si, Beger, Richard D., Davis, Kelly, Salminen, William F., Song, Byoung‐Joon, Mendrick, Donna L., Yu, Li‐Rong

“…Purpose Overdose of acetaminophen (APAP) is a major cause of acute liver failure. This study was aimed to identify pathways related to hepatotoxicity and…”
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US FDA 505(b)(2) NDA clinical, CMC and regulatory strategy concepts to expedite drug development by Salminen, William F., Aloba, Olu, Drew, Angela, Marcinowicz, Agnieszka, Huang, Madelyn

“…•505(b)(2) NDAs reflect a streamlined drug approval pathway and approach.•Clinical safety and efficacy data for the innovator drug can often be relied…”
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Streamlining nonclinical drug development using the FDA 505(b)(2) new drug application regulatory pathway by Salminen, William F., Wiles, Marc E., Stevens, Ruth E.

“…•505(b)(2) NDA nonclinical programs could be streamlined and reduced.•Nonclinical data for the innovator drug could be relied upon.•505(b)(2) NDAs reflect a…”
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Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes by Shi, Qiang, Greenhaw, James, Salminen, William F.

“…ABSTRACT(+)‐Usnic acid (UA) is consumed as a dietary supplement to promote weight loss; however, dietary supplements containing UA have been associated with…”
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Identification of Urinary microRNA Profiles in Rats That May Diagnose Hepatotoxicity by Yang, Xi, Greenhaw, James, Shi, Qiang, Su, Zhenqiang, Qian, Feng, Davis, Kelly, Mendrick, Donna L., Salminen, William F.

“…Circulating microRNAs (miRNAs) have emerged as novel noninvasive biomarkers for several diseases and other types of tissue injury. This study tested the…”
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Drug-Induced Liver Injury in Children: Clinical Observations, Animal Models, and Regulatory Status by Shi, Qiang, Yang, Xi, Greenhaw, James J., Salminen, Alec Thomas, Russotti, Gary M., Salminen, William F.

“…Drug-induced liver injury in children (cDILI) accounts for about 1% of all reported adverse drug reactions throughout all age groups, less than 10% of all…”
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Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells by Yang, Xi, Salminen, William F.

“…The widely used over-the-counter analgesic acetaminophen (APAP) is the leading cause of acute liver failure in the United States and due to this high…”
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Hepatic Cytochrome P450s Attenuate the Cytotoxicity Induced by Leflunomide and Its Active Metabolite A77 1726 in Primary Cultured Rat Hepatocytes by Shi, Qiang, Yang, Xi, Greenhaw, James, Salminen, William F.

“…The Black Box Warning section of the U.S. drug label for leflunomide was recently updated to include stronger warnings about potential hepatotoxicity from this…”
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Green tea epigallocatechin gallate binds to and inhibits respiratory complexes in swelling but not normal rat hepatic mitochondria by Weng, Zuquan, Zhou, Peng, Salminen, William F., Yang, Xi, Harrill, Alison H., Cao, Zhijun, Mattes, William B., Mendrick, Donna L., Shi, Qiang

“…•Epigallocatechin gallate does not affect normal mitochondrial functions.•Epigallocatechin gallate inhibits respiratory complexes in swelling…”
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A randomized controlled laboratory study on the long-term effects of methylphenidate on cardiovascular function and structure in rhesus monkeys by Wilkinson, James D., Callicott, Ralph, Salminen, William F., Sandhu, Satinder K., Greenhaw, James, Paredes, Angel, Davis, Kelly, Jones, Yvonne, Paule, Merle G., Slikker, William, Rusconi, Paolo G., Czachor, Jason, Bodien, Amy, Westphal, Joslyn A., Dauphin, Danielle D., Lipshultz, Steven E.

“…Background Whether long-term methylphenidate (MPH) results in any changes in cardiovascular function or structure can only be properly addressed through a…”
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Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes by Weng, Zuquan, Greenhaw, James, Salminen, William F., Shi, Qiang

“…► Epigallocatechin gallate (EGCG) bound to a subset of protein in the microsomes. ► EGCG decreased the Western blot signals of a selective group of protein. ►…”
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Mouse liver protein sulfhydryl depletion after acetaminophen exposure by Yang, Xi, Greenhaw, James, Shi, Qiang, Roberts, Dean W, Hinson, Jack A, Muskhelishvili, Levan, Davis, Kelly, Salminen, William F

“…Acetaminophen (APAP)-induced liver injury is the leading cause of acute liver failure in many countries. This study determined the extent of liver protein…”
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Changes in mouse liver protein glutathionylation after acetaminophen exposure by Yang, Xi, Greenhaw, James, Ali, Akhtar, Shi, Qiang, Roberts, Dean W, Hinson, Jack A, Muskhelishvili, Levan, Beger, Richard, Pence, Lisa M, Ando, Yosuke, Sun, Jinchun, Davis, Kelly, Salminen, William F

“…The role of protein glutathionylation in acetaminophen (APAP)-induced liver injury was investigated in this study. A single oral gavage dose of 150 or 300…”
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Comprehensive analysis of alterations in lipid and bile acid metabolism by carbon tetrachloride using integrated transcriptomics and metabolomics by Sun, Jinchun, Schmitt, Thomas, Schnackenberg, Laura K., Pence, Lisa, Ando, Yosuke, Greenhaw, James, Yang, Xi, Slavov, Svetoslav, Davis, Kelly, Salminen, William F., Mendrick, Donna L., Beger, Richard D.

“…Understanding mechanisms of liver injury can enable better preclinical testing and clinical management of patients. Carbon tetrachloride (CCl 4 ), used…”
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Synergistic interaction of ascorbic acid and green tea extract in preventing the browning of fresh cut apple slices by Salminen, William F., Russotti, Gary

“…A novel combination of ascorbic acid (AA) and green tea extract (GTE) was tested for its ability to prevent browning of fresh cut Red Delicious apple slices. A…”
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Effect of N-acetylcysteine on heat shock protein induction by acetaminophen in mouse liver by Salminen, Jr, W F, Voellmy, R, Roberts, S M

“…It was previously shown that a necrogenic dose of acetaminophen (APAP) induced the 25- and 70-kDa heat shock proteins (hsp25 and hsp70i) in mouse liver,…”
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Correlation between Glutathione Oxidation and Trimerization of Heat Shock Factor 1, an Early Step in Stress Induction of the Hsp Response by Zou, Jiangying, Salminen, William F., Roberts, Stephen M., Voellmy, Richard

“…The heat shock protein (Hsp) response is induced by heat shock and a large variety of different chemicals. Searching for a common denominator of these…”
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