Search Results - "Salminen, Aaro V"

Treatment of restless legs syndrome: Evidence‐based review and implications for clinical practice (Revised 2017) by Winkelmann, Juliane, Allen, Richard P., Högl, Birgit, Inoue, Yuichi, Oertel, Wolfgang, Salminen, Aaro V., Winkelman, John W., Trenkwalder, Claudia, Sampaio, Cristina

“…The objective of the current review was to update the previous evidence‐based medicine review of treatments for restless legs syndrome published in 2008. All…”
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Recessive Mutations in the α3 (VI) Collagen Gene COL6A3 Cause Early-Onset Isolated Dystonia by Zech, Michael, Lam, Daniel D., Francescatto, Ludmila, Schormair, Barbara, Salminen, Aaro V., Jochim, Angela, Wieland, Thomas, Lichtner, Peter, Peters, Annette, Gieger, Christian, Lochmüller, Hanns, Strom, Tim M., Haslinger, Bernhard, Katsanis, Nicholas, Winkelmann, Juliane

“…Isolated dystonia is a disorder characterized by involuntary twisting postures arising from sustained muscle contractions. Although autosomal-dominant…”
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Identification of Restless Legs Syndrome Genes by Mutational Load Analysis by Tilch, Erik, Schormair, Barbara, Zhao, Chen, Salminen, Aaro V., Antic Nikolic, Ana, Holzknecht, Evi, Högl, Birgit, Poewe, Werner, Bachmann, Cornelius G., Paulus, Walter, Trenkwalder, Claudia, Oertel, Wolfgang H., Hornyak, Magdolna, Fietze, Ingo, Berger, Klaus, Lichtner, Peter, Gieger, Christian, Peters, Annette, Müller‐Myhsok, Bertram, Hoischen, Alexander, Winkelmann, Juliane, Oexle, Konrad

“…Objective Restless legs syndrome is a frequent neurological disorder with substantial burden on individual well‐being and public health. Genetic risk loci have…”
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Sleep disturbance by pramipexole is modified by Meis1 in mice by Salminen, Aaro V., Schormair, Barbara, Flachskamm, Cornelia, Torres, Miguel, Müller‐Myhsok, Bertram, Kimura, Mayumi, Winkelmann, Juliane

“…Summary Meis homeobox 1 (Meis1) is a transcription factor functioning in the development of the nervous system and the cardiovascular system. Both common and…”
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Consensus guidelines on the construct validity of rodent models of restless legs syndrome by Salminen, Aaro V., Clemens, Stefan, García-Borreguero, Diego, Ghorayeb, Imad, Li, Yuqing, Manconi, Mauro, Ondo, William, Rye, David, Siegel, Jerome M., Silvani, Alessandro, Winkelman, John W., Allen, Richard P., Ferré, Sergi

“…ABSTRACT Our understanding of the causes and natural course of restless legs syndrome (RLS) is incomplete. The lack of objective diagnostic biomarkers remains…”
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Meis1 : effects on motor phenotypes and the sensorimotor system in mice by Salminen, Aaro V, Garrett, Lillian, Schormair, Barbara, Rozman, Jan, Giesert, Florian, Niedermeier, Kristina M, Becker, Lore, Rathkolb, Birgit, Rácz, Ildikó, Klingenspor, Martin, Klopstock, Thomas, Wolf, Eckhard, Zimmer, Andreas, Gailus-Durner, Valérie, Torres, Miguel, Fuchs, Helmut, Hrabě de Angelis, Martin, Wurst, Wolfgang, Hölter, Sabine M, Winkelmann, Juliane

“…encodes a developmental transcription factor and has been linked to restless legs syndrome (RLS) in genome-wide association studies. RLS is a movement disorder…”
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Peripheral hypoxia in restless legs syndrome (Willis-Ekbom disease) by Salminen, Aaro V, Rimpilä, Ville, Polo, Olli

“…OBJECTIVE:A case-control study to measure oxygen and carbon dioxide partial pressures in the legs in order to assess the involvement of peripheral hypoxia or…”
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Reassessment of candidate gene studies for idiopathic restless legs syndrome in a large genome-wide association study dataset of European ancestry by Schormair, Barbara, Zhao, Chen, Salminen, Aaro V, Oexle, Konrad, Winkelmann, Juliane

“…Abstract Study Objectives Several candidate gene studies have been published for idiopathic restless legs syndrome (RLS) in populations of European ancestry,…”
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Restless Legs Syndrome and Other Movement Disorders of Sleep—Treatment Update by Salminen, Aaro V., Winkelmann, Juliane

“…Purpose of review The purpose of this review article is to summarize and discuss the recent advances in the treatment of restless legs syndrome (RLS), as well…”
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Therapeutic effectiveness of thalidomide in a patient with treatment-resistant restless legs syndrome by Salminen, Aaro V, Schandra, Nathalie, Schormair, Barbara, Oexle, Konrad, Winkelmann, Juliane

“…Recent developments in the genetics of restless legs syndrome (RLS) revealed associations of disease risk with genetic loci containing the genes coding…”
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Consensus Guidelines on Rodent Models of Restless Legs Syndrome by Salminen, Aaro V., Silvani, Alessandro, Allen, Richard P., Clemens, Stefan, Garcia‐Borreguero, Diego, Ghorayeb, Imad, Ferré, Sergi, Li, Yuqing, Ondo, William, Picchietti, Daniel L., Rye, David, Siegel, Jerome M., Winkelman, John W., Manconi, Mauro

“…ABSTRACT Restless legs syndrome (RLS) is a chronic sensorimotor disorder diagnosed by clinical symptoms. It is challenging to translate the diagnostic…”
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A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice by Leu, Chia-Luen, Lam, Daniel D, Salminen, Aaro V, Wefers, Benedikt, Becker, Lore, Garrett, Lillian, Rozman, Jan, Wurst, Wolfgang, Hrabě de Angelis, Martin, Hölter, Sabine M, Winkelmann, Juliane, Williams, Rhîannan H

“…Abstract Restless legs syndrome (RLS) is a neurological disorder characterized by uncomfortable or unpleasant sensations in the legs during rest periods. To…”
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Collagen VI Regulates Motor Circuit Plasticity and Motor Performance by Cannabinoid Modulation by Lam, Daniel D, Williams, Rhîannan H, Lujan, Ernesto, Tanabe, Koji, Huber, Georg, Saw, Nay Lui, Merl-Pham, Juliane, Salminen, Aaro V, Lohse, David, Spendiff, Sally, Plastini, Melanie J, Zech, Michael, Lochmüller, Hanns, Geerlof, Arie, Hauck, Stefanie M, Shamloo, Mehrdad, Wernig, Marius, Winkelmann, Juliane

“…Collagen VI is a key component of muscle basement membranes, and genetic variants can cause monogenic muscular dystrophies. Conversely, human genetic studies…”
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Role of MEIS1 in restless legs syndrome: From GWAS to functional studies in mice by Salminen, Aaro V, Lam, Daniel D, Winkelmann, Juliane

“…MEIS1 is a transcription factor playing an important role in the development of several organs, including central and peripheral nervous systems. A genetic…”
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Transcutaneous carbon dioxide during sleep-disordered breathing by Rimpilä, Ville, Hosokawa, Keisuke, Huhtala, Heini, Saaresranta, Tarja, Salminen, Aaro V, Polo, Olli

“…Highlights • Transcutaneous CO2 (PtcCO2 ) measurement is sensitive to sleep-disordered breathing. • Different sleep apnoea types are characterized by different…”
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Reply to: Safety of dopamine agonists for treating restless legs syndrome by Salminen, Aaro V., Allen, Richard P., Högl, Birgit, Inoue, Yuichi, Oertel, Wolfgang, Winkelman, John W., Trenkwalder, Claudia, Sampaio, Cristina, Winkelmann, Juliane

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Reply to: A note on rotigotine for restless legs syndrome after renal transplantation by Salminen, Aaro V., Allen, Richard P., Högl, Birgit, Inoue, Yuichi, Oertel, Wolfgang, Winkelman, John W., Trenkwalder, Claudia, Sampaio, Cristina, Winkelmann, Juliane

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Disconnection between periodic leg movements and cortical arousals in spinal cord injury by Salminen, Aaro V, Manconi, Mauro, Rimpilä, Ville, Luoto, Teemu M, Koskinen, Eerika, Ferri, Raffaele, Ohman, Juha, Polo, Olli

“…In this study we examine the temporal connection between periodic leg movements (PLMs) and cortical arousals, as well as the treatment effect of pramipexole,…”
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Transcutaneous CO2 plateau as set-point for respiratory drive during upper airway flow-limitation by Rimpilä, Ville, Saaresranta, Tarja, Huhtala, Heini, Virkki, Arho, Salminen, Aaro V, Polo, Olli

“…Highlights • Transcutaneous CO2 increases during progressive flow limitation. • Respiratory efforts during flow limitation remain low until tcCO2 plateau is…”
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Pramipexole alters thermoregulation in restless legs syndrome by Salminen, Aaro V, Rimpilä, Ville, Polo, Olli

“…Previous studies have associated restless legs syndrome (RLS) with peripheral hypoxia and impaired thermoregulation in the lower extremities. We performed…”
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