Search Results - "Salmena, L"

INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia by Dzneladze, I, He, R, Woolley, J F, Son, M H, Sharobim, M H, Greenberg, S A, Gabra, M, Langlois, C, Rashid, A, Hakem, A, Ibrahimova, N, Arruda, A, Löwenberg, B, Valk, P J M, Minden, M D, Salmena, L

“…In this study, we investigated the role of i nositol polyphosphate-4-phosphatase, type-II (INPP4B) in acute myeloid leukemia (AML). We observed that AML…”
Get full text

BRCA1 mRNA levels following a 4–6-week intervention with oral 3,3′-diindolylmethane by Kotsopoulos, J, Zhang, S, Akbari, M, Salmena, L, Llacuachaqui, M, Zeligs, M, Sun, P, Narod, S A

“…Background: Haploinsufficiency may contribute to the development of breast cancer among women with a BRCA1 mutation. Thus, interventions that enhance BRCA1…”
Get full text

miR-214 in stroma cells and tumor progression by Dettori, D, Orso, F, Penna, E, Salmena, L, Pandolfi, P.P, Caselle, M, Taverna, D

Get full text

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity by Salmena, Leonardo, Lemmers, Benedicte, Hakem, Anne, Matysiak-Zablocki, Elzbieta, Murakami, Kiichi, Au, P Y Billie, Berry, Donna M, Tamblyn, Laura, Shehabeldin, Amro, Migon, Eva, Wakeham, Andrew, Bouchard, Denis, Yeh, Wen Chen, McGlade, Jane C, Ohashi, Pamela S, Hakem, Razqallah

“…Defects in death receptor-mediated apoptosis have been linked to cancer and autoimmune disease in humans. The in vivo role of caspase 8, a component of this…”
Get full text

Prognostic value of INPP4B protein immunohistochemistry in ovarian cancer by Salmena, L, Shaw, P, Fans, I, McLaughlin, Rosen, B, Risch, H, Mitchell, C, Sun, P, Narod, S A, Kotsopoulos, J

“…Ovarian cancer is associated with poor prognosis and altered protein expression patterns may be useful for identifying patients likely to have poor disease…”
Get more information

Tenets of PTEN Tumor Suppression by Salmena, Leonardo, Carracedo, Arkaitz, Pandolfi, Pier Paolo

“…Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic…”
Get full text

CD95 apoptosis resistance in certain cells can be overcome by noncanonical activation of caspase-8 by Barnhart, B C, Pietras, E M, Algeciras-Schimnich, A, Salmena, L, Sayama, K, Hakem, R, Peter, M E

“…CD95 apoptosis resistance of tumor cells is often acquired through mutations in the death domain (DD) of one of the CD95 alleles. Furthermore, Type I cancer…”
Get full text

Discovery of Essential microRNA in Prostate Cancer Cells by Chow, J., Lee, D.K.C., Chen, K., Fu, N., Grigore, I., Gabra, M.M., Salmena, L.

Get full text

Identifying the INPP4B-lysosome signaling axis as a putative target in acute myeloid leukemia by Chen, K., Woolley, J.F., Lee, D.K.C., Melo, C.M.P., Saffi, G.T., He, A., Dhir, S., Chow, J.T.S., Botelho, R.J., Salmena, L.

Get full text

Abstract P1-09-03: Withdrawn by Kotsopoulos, J, Zaman, T, Lubinski, J, Sun, P, Salmena, L, Narod, SA

“…Abstract This abstract was withdrawn by the authors. Citation Format: Kotsopoulos J, Zaman T, Lubinski J, Sun P, Salmena L, Narod SA. Withdrawn [abstract]. In:…”
Get full text

Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling by Gewinner, Christina, Wang, Zhigang C., Richardson, Andrea, Teruya-Feldstein, Julie, Etemadmoghadam, Dariush, Bowtell, David, Barretina, Jordi, Lin, William M., Rameh, Lucia, Salmena, Leonardo, Pandolfi, Pier Paolo, Cantley, Lewis C.

“…We report that knocking down the expression of inositol polyphosphate 4-phosphatase type II (INPP4B) in human epithelial cells, like knockdown of PTEN,…”
Get full text

Abstract P5-09-01: Plasma osteoprotegerin and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers by Kotsopoulos, J, Oden, L, Akbari, M, Singer, C, Sun, P, Salmena, L, Narod, S

“…Abstract This abstract was withdrawn by the authors…”
Get full text

Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder by Salmena, Leonardo, Hakem, Razqallah

“…Caspase-8 is best known for its cell death function via death receptors. Recent evidence indicates that caspase-8 also has nonapoptotic functions. Caspase-8…”
Get full text

440 - miR-214 in stroma cells and tumor progression by Dettori, D., Orso, F., Penna, E., Salmena, L., Pandolfi, P.P., Caselle, M., Taverna, D.

Get full text

Requirement for Caspase-8 in NF-κB Activation by Antigen Receptor by Su, Helen, Bidère, Nicolas, Zheng, Lixin, Cubre, Alan, Sakai, Keiko, Dale, Janet, Salmena, Leonardo, Hakem, Razqallah, Straus, Stephen, Lenardo, Michael

“…Caspase-8, a proapoptotic protease, has an essential role in lymphocyte activation and protective immunity. We show that caspase-8 deficiency (CED) in humans…”
Get full text

Plasma osteoprotegerin and breast cancer risk in BRCA1 and BRCA2 mutation carriers by Odén, Lovisa, Akbari, Mohammad, Zaman, Tasnim, Singer, Christian F, Sun, Ping, Narod, Steven A, Salmena, Leonardo, Kotsopoulos, Joanne

“…Emerging evidence suggests a role of receptor activator of nuclear factor κB (RANK)/RANK ligand (RANKL) signaling in breast cancer development. Lower…”
Get full text

Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity by McPherson, John Peter, Tamblyn, Laura, Elia, Andrew, Migon, Eva, Shehabeldin, Amro, Matysiak-Zablocki, Elzbieta, Lemmers, Bénédicte, Salmena, Leonardo, Hakem, Anne, Fish, Jason, Kassam, Farah, Squire, Jeremy, Bruneau, Benoit G, Hande, M Prakash, Hakem, Razqallah

“…The Drosophila melanogaster warts/lats tumour suppressor has two mammalian counterparts LATS1/Warts‐1 and LATS2/Kpm. Here, we show that mammalian Lats…”
Get full text

Apoptosis Caused by p53-Induced Protein with Death Domain (PIDD) Depends on the Death Adapter Protein RAIDD by Berube, Christina, Boucher, Louis-Martin, Ma, Weili, Wakeham, Andrew, Salmena, Leonardo, Hakem, Razqallah, Yeh, Wen-Chen, Mak, Tak W., Benchimol, Samuel

“…The p53 tumor suppressor promotes cell cycle arrest or apoptosis in response to diverse stress stimuli. p53-mediated cell death depends in large part on…”
Get full text

Cellular FLICE-inhibitory protein is required for T cell survival and cycling by Chau, Hien, Wong, Veronica, Chen, Nien-Jung, Huang, Huey-Lan, Lin, Wen-Jye, Mirtsos, Christine, Elford, Alisha R, Bonnard, Madeleine, Wakeham, Andrew, You-Ten, Annick Itie, Lemmers, Bénédicte, Salmena, Leonardo, Pellegrini, Marc, Hakem, Razq, Mak, Tak W, Ohashi, Pamela, Yeh, Wen-Chen

“…Fas-associated death domain (FADD) and caspase-8 are key signal transducers for death receptor-induced apoptosis, whereas cellular FLICE-inhibitory protein…”
Get full text

A Role for PML in Innate Immunity by Lunardi, Andrea, Gaboli, Mirella, Giorgio, Marco, Rivi, Roberta, Bygrave, Anne, Antoniou, Michael, Drabek, Dubravka, Dzierzak, Elaine, Fagioli, Marta, Salmena, Leonardo, Botto, Marina, Cordon-Cardo, Carlos, Luzzatto, Lucio, Pelicci, Pier Giuseppe, Grosveld, Frank, Pandolfi, Pier Paolo

“…The promyelocytic leukemia gene (PML) of acute promyelocytic leukemia is an established tumor suppressor gene with critical functions in growth suppression,…”
Get full text