Search Results - "Sally Ward, E."

Targeting FcRn to Generate Antibody-Based Therapeutics by Ward, E. Sally, Ober, Raimund J.

“…The MHC class I-related receptor FcRn serves multiple roles ranging from the regulation of levels of IgG isotype antibodies and albumin throughout the body to…”
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Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans by Ulrichts, Peter, Guglietta, Antonio, Dreier, Torsten, van Bragt, Tonke, Hanssens, Valérie, Hofman, Erik, Vankerckhoven, Bernhardt, Verheesen, Peter, Ongenae, Nicolas, Lykhopiy, Valentina, Enriquez, F Javier, Cho, JunHaeng, Ober, Raimund J, Ward, E Sally, de Haard, Hans, Leupin, Nicolas

“…Intravenous Ig (IVIg), plasma exchange, and immunoadsorption are frequently used in the management of severe autoimmune diseases mediated by pathogenic IgG…”
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Engineering a HER2-specific antibody–drug conjugate to increase lysosomal delivery and therapeutic efficacy by Kang, Jeffrey C., Sun, Wei, Khare, Priyanka, Karimi, Mostafa, Wang, Xiaoli, Shen, Yang, Ober, Raimund J., Ward, E. Sally

“…We improve the potency of antibody–drug conjugates (ADCs) containing the human epidermal growth factor receptor 2 (HER2)-specific antibody pertuzumab by…”
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Detection of phosphatidylserine-positive exosomes as a diagnostic marker for ovarian malignancies: a proof of concept study by Lea, Jayanthi, Sharma, Raghava, Yang, Fan, Zhu, Hong, Ward, E Sally, Schroit, Alan J

“…There are no suitable screening modalities for ovarian carcinomas (OC) and repeated imaging and CA-125 levels are often needed to triage equivocal ovarian…”
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High Accuracy 3D Quantum Dot Tracking with Multifocal Plane Microscopy for the Study of Fast Intracellular Dynamics in Live Cells by Ram, Sripad, Prabhat, Prashant, Chao, Jerry, Sally Ward, E., Ober, Raimund J.

“…Single particle tracking in three dimensions in a live cell environment holds the promise of revealing important new biological insights. However, conventional…”
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Macrophage-Mediated Trogocytosis Leads to Death of Antibody-Opsonized Tumor Cells by Velmurugan, Ramraj, Challa, Dilip K, Ram, Sripad, Ober, Raimund J, Ward, E Sally

“…Understanding the complex behavior of effector cells such as monocytes or macrophages in regulating cancerous growth is of central importance for cancer…”
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Targeting FcRn for the modulation of antibody dynamics by Ward, E. Sally, Devanaboyina, Siva Charan, Ober, Raimund J.

“…•Multiple factors can impact the in vivo pharmacokinetics of an IgG.•Targeting FcRn with inhibitors reduces the levels of circulating IgG.•The engineering of…”
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BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation by Deason, Krystin, Troutman, Ty Dale, Jain, Aakanksha, Challa, Dilip K, Mandraju, Rajakumar, Brewer, Travis, Ward, E Sally, Pasare, Chandrashekhar

“…The toll-like receptor (TLR) and interleukin (IL)-1 family of receptors share several signaling components, including the most upstream adapter, MyD88. We…”
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3D Single Molecule Tracking with Multifocal Plane Microscopy Reveals Rapid Intercellular Transferrin Transport at Epithelial Cell Barriers by Ram, Sripad, Kim, Dongyoung, Ober, Raimund J., Ward, E. Sally

“…The study of intracellular transport pathways at epithelial cell barriers that line diverse tissue sites is fundamental to understanding tissue homeostasis. A…”
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A two-stage method for automated detection of ring-like endosomes in fluorescent microscopy images by Lin, Dongyun, Lin, Zhiping, Cao, Jiuwen, Velmurugan, Ramraj, Ward, E Sally, Ober, Raimund J

“…Endosomes are subcellular organelles which serve as important transport compartments in eukaryotic cells. Fluorescence microscopy is a widely applied…”
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Engineered clearing agents for the selective depletion of antigen-specific antibodies by Devanaboyina, Siva Charan, Khare, Priyanka, Challa, Dilip K., Ober, Raimund J., Ward, E. Sally

“…Here we have designed a novel class of engineered antibody-based reagents (‘Seldegs’) that induce the selective degradation of antigen-specific antibodies. We…”
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Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels by Ward, E Sally, Vaccaro, Carlos, Zhou, Jinchun, Ober, Raimund J

“…We have engineered the Fc region of a human immunoglobulin G (IgG) to generate a mutated antibody that modulates the concentrations of endogenous IgGs in vivo…”
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Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders by Ward, E. Sally, Gelinas, Deborah, Dreesen, Erwin, Van Santbergen, Jolien, Andersen, Jan Terje, Silvestri, Nicholas J., Kiss, Joseph E., Sleep, Darrell, Rader, Daniel J., Kastelein, John J. P., Louagie, Els, Vidarsson, Gestur, Spriet, Isabel

“…Serum albumin (SA), the most abundant soluble protein in the body, maintains plasma oncotic pressure and regulates the distribution of vascular fluid and has a…”
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Determination of localization accuracy based on experimentally acquired image sets: applications to single molecule microscopy by Tahmasbi, Amir, Ward, E Sally, Ober, Raimund J

“…Fluorescence microscopy is a photon-limited imaging modality that allows the study of subcellular objects and processes with high specificity. The best…”
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Beyond Rayleigh's Criterion: A Resolution Measure with Application to Single-Molecule Microscopy by Ram, Sripad, Ward, E. Sally, Ober, Raimund J.

“…Rayleigh's criterion is extensively used in optical microscopy for determining the resolution of microscopes. This criterion imposes a resolution limit that…”
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Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice by Montoyo, Héctor Pérez, Vaccaro, Carlos, Hafner, Martin, Ober, Raimund J, Mueller, Werner, Ward, E. Sally

“…The MHC class I-related receptor FcRn regulates the levels and persistence of IgG in vivo. This receptor salvages IgG from lysosomal degradation within cells,…”
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Myelin oligodendrocyte glycoprotein-specific antibodies from multiple sclerosis patients exacerbate disease in a humanized mouse model by Khare, Priyanka, Challa, Dilip K., Devanaboyina, Siva Charan, Velmurugan, Ramraj, Hughes, Samuel, Greenberg, Benjamin M., Ober, Raimund J., Ward, E. Sally

“…Myelin oligodendrocyte glycoprotein (MOG) is exposed on the outer surface of the myelin sheath, and as such, represents a possible target antigen for…”
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Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model by Patel, Dipesh A, Puig-Canto, Alberto, Challa, Dilip Kumar, Perez Montoyo, Héctor, Ober, Raimund J, Ward, E Sally

“…Multiple autoimmune diseases are characterized by the involvement of autoreactive Abs in pathogenesis. Problems associated with existing therapeutics such as…”
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Targeting Phosphatidylserine with Calcium-Dependent Protein-Drug Conjugates for the Treatment of Cancer by Li, Ran, Chiguru, Srinivas, Li, Li, Kim, Dongyoung, Velmurugan, Ramraj, Kim, David, Devanaboyina, Siva Charan, Tian, Hong, Schroit, Alan, Mason, Ralph P, Ober, Raimund J, Ward, E Sally

“…In response to cellular stress, phosphatidylserine is exposed on the outer membrane leaflet of tumor blood vessels and cancer cells, motivating the development…”
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Designing the focal plane spacing for multifocal plane microscopy by Tahmasbi, Amir, Ram, Sripad, Chao, Jerry, Abraham, Anish V, Tang, Felix W, Ward, E Sally, Ober, Raimund J

“…Multifocal plane microscopy (MUM) has made it possible to study subcellular dynamics in 3D at high temporal and spatial resolution by simultaneously imaging…”
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