Search Results - "Salloway, Stephen P"

The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model by Bateman, Randall J, Benzinger, Tammie L, Berry, Scott, Clifford, David B, Duggan, Cynthia, Fagan, Anne M, Fanning, Kathleen, Farlow, Martin R, Hassenstab, Jason, McDade, Eric M, Mills, Susan, Paumier, Katrina, Quintana, Melanie, Salloway, Stephen P, Santacruz, Anna, Schneider, Lon S, Wang, Guoqiao, Xiong, Chengjie

“…Abstract Introduction The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) trial is an adaptive platform trial testing multiple drugs to slow or…”
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Developing retinal biomarkers for the earliest stages of Alzheimer's disease: What we know, what we don't, and how to move forward by Alber, Jessica, Goldfarb, Danielle, Thompson, Louisa I., Arthur, Edmund, Hernandez, Kimberly, Cheng, Derrick, DeBuc, Delia Cabrera, Cordeiro, Francesca, Provetti‐Cunha, Leonardo, den Haan, Jurre, Van Stavern, Gregory P., Salloway, Stephen P., Sinoff, Stuart, Snyder, Peter J.

“…The last decade has seen a substantial increase in research focused on the identification, development, and validation of diagnostic and prognostic retinal…”
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Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression by Malone, Donald A, Dougherty, Darin D, Rezai, Ali R, Carpenter, Linda L, Friehs, Gerhard M, Eskandar, Emad N, Rauch, Scott L, Rasmussen, Steven A, Machado, Andre G, Kubu, Cynthia S, Tyrka, Audrey R, Price, Lawrence H, Stypulkowski, Paul H, Giftakis, Jonathon E, Rise, Mark T, Malloy, Paul F, Salloway, Stephen P, Greenberg, Benjamin D

“…Background We investigated the use of deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) for treatment refractory depression. Methods…”
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Three-Year Outcomes in Deep Brain Stimulation for Highly Resistant Obsessive-Compulsive Disorder by GREENBERG, Benjamin D, MALONE, Donald A, FRIEHS, Gerhard M, REZAI, Ali R, KUBU, Cynthia S, MALLOY, Paul F, SALLOWAY, Stephen P, OKUN, Michael S, GOODMAN, Wayne K, RASMUSSEN, Steven A

“…Deep brain stimulation (DBS) of the anterior limb of the internal capsule has been shown to be beneficial in the short term for obsessive-compulsive disorder…”
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Impaired default network functional connectivity in autosomal dominant Alzheimer disease by Chhatwal, Jasmeer P., Schultz, Aaron P., Johnson, Keith, Benzinger, Tammie L.S., Jack, Clifford, Ances, Beau M., Sullivan, Caroline A., Salloway, Stephen P., Ringman, John M., Koeppe, Robert A., Marcus, Daniel S., Thompson, Paul, Saykin, Andrew J., Correia, Stephen, Schofield, Peter R., Rowe, Christopher C., Fox, Nick C., Brickman, Adam M., Mayeux, Richard, McDade, Eric, Bateman, Randall, Fagan, Anne M., Goate, Allison M., Xiong, Chengjie, Buckles, Virginia D., Morris, John C., Sperling, Reisa A.

“…OBJECTIVE:To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in a large cross-sectional cohort of subjects from families harboring…”
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Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer's disease by Howe, Matthew D, Britton, Karysa J, Joyce, Hannah E, Menard, William, Emrani, Sheina, Kunicki, Zachary J, Faust, Melanie A, Dawson, Brittany C, Riddle, Meghan C, Huey, Edward D, Janelidze, Shorena, Hansson, Oskar, Salloway, Stephen P

“…With the approval of disease-modifying treatments (DMTs) for early Alzheimer's disease (AD), there is an increased need for efficient and non-invasive…”
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Advancing combination therapy for Alzheimer's disease by Salloway, Stephen P., Sevingy, Jeff, Budur, Kumar, Pederson, Jan Torleif, DeMattos, Ronald B., Von Rosenstiel, Philipp, Paez, Antonio, Evans, Rebecca, Weber, Christopher J., Hendrix, James A., Worley, Susan, Bain, Lisa J., Carrillo, Maria C.

“…The study of Alzheimer's disease (AD) has led to an increased understanding of the multiple pathologies and pathways of the disease. As such, it has been…”
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Adding cognition to AT(N) models improves prediction of cognitive and functional decline by O'Shea, Deirdre M., Thomas, Kelsey R., Asken, Breton, Lee, Athene K.W., Davis, Jennifer D., Malloy, Paul F., Salloway, Stephen P., Correia, Stephen

“…Introduction This study sought to determine whether adding cognition to a model with Alzheimer's disease biomarkers based on the amyloid, tau, and…”
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Donanemab in Early Alzheimer’s Disease by Mintun, Mark A, Lo, Albert C, Duggan Evans, Cynthia, Wessels, Alette M, Ardayfio, Paul A, Andersen, Scott W, Shcherbinin, Sergey, Sparks, JonDavid, Sims, John R, Brys, Miroslaw, Apostolova, Liana G, Salloway, Stephen P, Skovronsky, Daniel M

“…A phase 2 trial of donanemab, an antibody that targets amyloid deposited in the brain, showed a better composite score for cognition and for the ability to…”
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Disruption of cholinergic neurotransmission, within a cognitive challenge paradigm, is indicative of Aβ-related cognitive impairment in preclinical Alzheimer's disease after a 27-month delay interval by Alber, Jessica, Maruff, Paul, Santos, Cláudia Y, Ott, Brian R, Salloway, Stephen P, Yoo, Don C, Noto, Richard B, Thompson, Louisa I, Goldfarb, Danielle, Arthur, Edmund, Song, Alex, Snyder, Peter J

“…Abnormal beta-amyloid (Aβ) is associated with deleterious changes in central cholinergic tone in the very early stages of Alzheimer's disease (AD), which may…”
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Heed the Warning Signs to Avoid Serious ARIA by Salloway, Stephen P, Schrag, Matthew, Saver, Jeffrey L

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Real-World Application of Anti-β-Amyloid Monoclonal Antibodies: Untangling Eligibility by Howe, Matthew D, Rabinovici, Gil D, Salloway, Stephen P

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Gamma Ventral Capsulotomy in Intractable Obsessive-Compulsive Disorder by Rasmussen, Steven A., Noren, Georg, Greenberg, Benjamin D., Marsland, Richard, McLaughlin, Nicole C., Malloy, Paul J., Salloway, Stephen P., Strong, David R., Eisen, Jane L., Jenike, Michael A., Rauch, Scott L., Baer, Lee, Lindquist, Christer

“…Despite the development of effective pharmacologic and cognitive behavioral treatments for obsessive-compulsive disorder (OCD), some patients continue to be…”
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Donepezil in vascular dementia: combined analysis of two large-scale clinical trials by Román, Gustavo C, Wilkinson, David G, Doody, Rachelle S, Black, Sandra E, Salloway, Stephen P, Schindler, Rachel J

“…There are currently no drugs approved to treat vascular dementia (VaD). The objective of this study was to determine if treatment with donepezil, an…”
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Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease by Son, Hye Joo, Kim, Jae Seung, Bateman, Randall J, Kim, Seonok, Llibre-Guerra, Jorge J, Day, Gregory S, Chhatwal, Jasmeer P, Berman, Sarah B, Schofield, Peter R, Jucker, Mathias, Levin, Johannes, Lee, Jae-Hong, Perrin, Richard J, Morris, John C, Cruchaga, Carlos, Hassenstab, Jason, Salloway, Stephen P, Lee, Jai-Hyuen, Daniels, Alisha

“…It remains unknown whether the associations between protective lifestyles and sporadic dementia risk reported in observational studies also affect age at…”
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Aggregated Tau Measured by Visual Interpretation of Flortaucipir Positron Emission Tomography and the Associated Risk of Clinical Progression of Mild Cognitive Impairment and Alzheimer Disease: Results From 2 Phase III Clinical Trials by Lu, Ming, Pontecorvo, Michael J, Devous, Sr, Michael D, Arora, Anupa K, Galante, Nicholas, McGeehan, Anne, Devadanam, Catherine, Salloway, Stephen P, Doraiswamy, P Murali, Curtis, Craig, Truocchio, Stephen P, Flitter, Matthew, Locascio, Tricia, Devine, Marybeth, Zimmer, Jennifer A, Fleisher, Adam S, Mintun, Mark A

“…Flortaucipir positron emission tomography (PET) scans, rated with a novel, US Food and Drug Administration-approved, clinically applicable visual…”
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Utility of cerebrovascular imaging biomarkers to detect cerebral amyloidosis by Howe, Matthew D., Caruso, Megan R., Manoochehri, Masood, Kunicki, Zachary J., Emrani, Sheina, Rudolph, James L., Huey, Edward D., Salloway, Stephen P., Oh, Hwamee

“…INTRODUCTION The relationship between cerebrovascular disease (CVD) and amyloid beta (Aβ) in Alzheimer's disease (AD) is understudied. We hypothesized that…”
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Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS) by Tang, Mengxuan, AB, Ryman, Davis C, MD, McDade, Eric, DO, Jasielec, Mateusz S, MS, Buckles, Virginia D, Prof, Cairns, Nigel J, Prof, Fagan, Anne M, Prof, Goate, Alison, Prof, Marcus, Daniel S, PhD, Xiong, Chengjie, PhD, Allegri, Ricardo F, MD, Chhatwal, Jasmeer P, MD, Danek, Adrian, Prof, Farlow, Martin R, Prof, Fox, Nick C, Prof, Ghetti, Bernardino, Prof, Graff-Radford, Neill R, MD, Laske, Christopher, Prof, Martins, Ralph N, Prof, Masters, Colin L, Prof, Mayeux, Richard P, Prof, Ringman, John M, Prof, Rossor, Martin N, Prof, Salloway, Stephen P, Prof, Schofield, Peter R, Prof, Morris, John C, Prof, Bateman, Randall J, Prof

“…Summary Background Autosomal dominant familial Alzheimer's disease (ADAD) is a rare disorder with non-amnestic neurological symptoms in some clinical…”
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Safety and Tolerability of APOE Genotyping and Disclosure in Cognitively Normal Volunteers From the Butler Alzheimer’s Prevention Registry by Alber, Jessica, Popescu, Dominique, Thompson, Louisa I., Tonini, Gina-Marie, Arthur, Edmund, Oh, Hwamee, Correia, Stephen, Salloway, Stephen P., Lee, Athene K.

“…Aims: Alzheimer’s disease (AD) is a gradually progressive neurodegenerative disease that ultimately results in total loss of cognitive and functional…”
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The impact of APOE genotype disclosure on lifestyle behaviors and decisions about future directives by Popescu, Dominique L, Alber, Jessica, Thompson, Louisa I, Arthur, Edmund, Oh, Hwamee, Correia, Stephen, Salloway, Stephen P., Lee, Athene KW

“…Background Studies have shown apolipoprotein E (APOE) genotype disclosure to be safe and well tolerated in cognitively unimpaired (CU) older adults. Genotyping…”
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