Search Results - "Salley, JP"

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes by Thornberry, Nancy A, Bull, Herbert G, Calaycay, Jimmy R, Chapman, Kevin T, Howard, Andrew D, Kostura, Matthew J, Miller, Douglas K, Molineaux, Susan M, Weidner, Jeffrey R, Aunins, John, Elliston, Keith O, Ayala, Julia M, Casano, Francesca J, Chin, Jayne, Ding, Gloria J.-F, Egger, Linda A, Gaffney, Erin P, Limjuco, Guadalupe, Palyha, Oksana C, Raju, S. M, Rolando, Anna M, Salley, J. Paul, Yamin, Ting-Ting, Lee, Terry D, Shively, John E, MacCross, Malcolm, Mumford, Richard A, Schmidt, John A, Tocci, Michael J

“…Interleukin-1 beta (IL-1 beta)-converting enzyme cleaves the IL-1 beta precursor to mature IL-1 beta, an important mediator of inflammation. The identification…”
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IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31- kDa IL-1 alpha by Howard, AD, Kostura, MJ, Thornberry, N, Ding, GJ, Limjuco, G, Weidner, J, Salley, JP, Hogquist, KA, Chaplin, DD, Mumford, RA

“…IL-1 converting enzyme (ICE) specifically cleaves the human IL-1 beta precursor at two sequence-related sites: Asp27-Gly28 (site 1) and Asp116-Ala117 (site 2)…”
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Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells by Miller, D.K., Ayala, J.M., Egger, L.A., Raju, S.M., Yamin, T.T., Ding, G.J., Gaffney, E.P., Howard, A.D., Palyha, O.C., Rolando, A.M.

“…Interleukin-1 beta-converting enzyme (ICE) was purified from dialyzed cytoplasmic extracts of THP.1 human monocytic cells by a combination of DEAE-5PW and…”
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