Search Results - "Sallam, Tamer"

Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation by Kan, Ryan L., Chen, Jianjun, Sallam, Tamer

“…Epigenetic modifications occur on genomic DNA and histones to influence gene expression. More recently, the discovery that mRNA undergoes similar chemical…”
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A (cholesterol) crystal clear path to inflammasome activation in atherosclerosis by Li, Xiang, Sallam, Tamer

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Endothelial cells LEENE on noncoding RNAs in diabetic vasculopathy by Kallapur, Aneesh, Sallam, Tamer

“…Long noncoding RNAs (lncRNAs) have emerged as key mediators of regulated gene expression in diverse biologic contexts, including cardiovascular disease. In…”
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The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance by Lee, Changhan, Zeng, Jennifer, Drew, Brian G., Sallam, Tamer, Martin-Montalvo, Alejandro, Wan, Junxiang, Kim, Su-Jeong, Mehta, Hemal, Hevener, Andrea L., de Cabo, Rafael, Cohen, Pinchas

“…Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The identification of a short open…”
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Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA by Sallam, Tamer, Jones, Marius, Thomas, Brandon J, Wu, Xiaohui, Gilliland, Thomas, Qian, Kevin, Eskin, Ascia, Casero, David, Zhang, Zhengyi, Sandhu, Jaspreet, Salisbury, David, Rajbhandari, Prashant, Civelek, Mete, Hong, Cynthia, Ito, Ayaka, Liu, Xin, Daniel, Bence, Lusis, Aldons J, Whitelegge, Julian, Nagy, Laszlo, Castrillo, Antonio, Smale, Stephen, Tontonoz, Peter

“…The conserved long noncoding RNA MeXis has anti-atherosclerotic effects in mice by acting with the nuclear hormone receptor LXR in macrophages to promote…”
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Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis by Sallam, Tamer, Jones, Marius C., Gilliland, Thomas, Zhang, Li, Wu, Xiaohui, Eskin, Ascia, Sandhu, Jaspreet, Casero, David, Vallim, Thomas Q. de Aguiar, Hong, Cynthia, Katz, Melanie, Lee, Richard, Whitelegge, Julian, Tontonoz, Peter

“…The activation of lipid X receptors (LXRs) in mouse liver not only promotes cholesterol efflux but also inhibits cholesterol synthesis simultaneously; this is…”
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Long Noncoding RNA Facilitated Gene Therapy Reduces Atherosclerosis in a Murine Model of Familial Hypercholesterolemia by Tontonoz, Peter, Wu, Xiaohui, Jones, Marius, Zhang, Zhengyi, Salisbury, David, Sallam, Tamer

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Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP by Zhang, Li, Rajbhandari, Prashant, Priest, Christina, Sandhu, Jaspreet, Wu, Xiaohui, Temel, Ryan, Castrillo, Antonio, de Aguiar Vallim, Thomas Q, Sallam, Tamer, Tontonoz, Peter

“…Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs. Here, we report that RNF145, a previously uncharacterized ER membrane…”
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Genetic Architecture of Insulin Resistance in the Mouse by Parks, Brian W., Sallam, Tamer, Mehrabian, Margarete, Psychogios, Nikolas, Hui, Simon T., Norheim, Frode, Castellani, Lawrence W., Rau, Christoph D., Pan, Calvin, Phun, Jennifer, Zhou, Zhenqi, Yang, Wen-Pin, Neuhaus, Isaac, Gargalovic, Peter S., Kirchgessner, Todd G., Graham, Mark, Lee, Richard, Tontonoz, Peter, Gerszten, Robert E., Hevener, Andrea L., Lusis, Aldons J.

“…Insulin resistance (IR) is a complex trait with multiple genetic and environmental components. Confounded by large differences between the sexes, environment,…”
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A PPARγ/long noncoding RNA axis regulates adipose thermoneutral remodeling in mice by Zhang, Zhengyi, Cui, Ya, Su, Vivien, Wang, Dan, Tol, Marcus J, Cheng, Lijing, Wu, Xiaohui, Kim, Jason, Rajbhandari, Prashant, Zhang, Sicheng, Li, Wei, Tontonoz, Peter, Villanueva, Claudio J, Sallam, Tamer

“…Interplay between energy-storing white adipose cells and thermogenic beige adipocytes contributes to obesity and insulin resistance. Irrespective of…”
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Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice by Zhang, Zhengyi, Feng, An-Chieh, Salisbury, David, Liu, Xin, Wu, Xiaohui, Kim, Jason, Lapina, Irina, Wang, Dan, Lee, Brennan, Fraga, Josue, Pan, Calvin, Williams, Kevin J., Lusis, Aldons J., Scumpia, Phil, Sallam, Tamer

“…Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of functionally versatile proteins that play critical roles in the biogenesis, cellular…”
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Long Noncoding RNA Discovery in Cardiovascular Disease by Sallam Tamer, Sandhu Jaspreet, Tontonoz, Peter

“…Despite significant improvements during the past 3 decades, cardiovascular disease remains a leading worldwide health epidemic. The recent identification of a…”
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Cancer therapy's impact on lipid metabolism: Mechanisms and future avenues by Bhatnagar, Roshni, Dixit, Neal M, Yang, Eric H, Sallam, Tamer

“…Atherosclerotic cardiovascular disease is a growing threat among cancer patients. Not surprisingly, cancer-targeting therapies have been linked to metabolic…”
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Cardiac TRPV1 afferent signaling promotes arrhythmogenic ventricular remodeling after myocardial infarction by Yoshie, Koji, Rajendran, Pradeep S, Massoud, Louis, Mistry, Janki, Swid, M Amer, Wu, Xiaohui, Sallam, Tamer, Zhang, Rui, Goldhaber, Joshua I, Salavatian, Siamak, Ajijola, Olujimi A

“…Chronic sympathoexcitation is implicated in ventricular arrhythmogenesis (VAs) following myocardial infarction (MI), but the critical neural pathways involved…”
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RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs by Wang, Jiexin, Rajbhandari, Prashant, Damianov, Andrey, Han, Areum, Sallam, Tamer, Waki, Hironori, Villanueva, Claudio J, Lee, Stephen D, Nielsen, Ronni, Mandrup, Susanne, Reue, Karen, Young, Stephen G, Whitelegge, Julian, Saez, Enrique, Black, Douglas L, Tontonoz, Peter

“…A highly orchestrated gene expression program establishes the properties that define mature adipocytes, but the contribution of posttranscriptional factors to…”
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Changes in lipid composition associated with electronic cigarette use by Middlekauff, Holly R, William, Kevin J, Su, Baolong, Haptonstall, Kacey, Araujo, Jesus A, Wu, Xiaohui, Kim, Jason, Sallam, Tamer

“…Electronic cigarette use is on the rise despite a number of reports linking electronic cigarettes with adverse health outcomes. Recent studies have suggested…”
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Review of Side-Effect Profile of Combination Ezetimibe and Statin Therapy in Randomized Clinical Trials by Kashani, Amir, MS, MD, Sallam, Tamer, MD, Bheemreddy, Swarna, MD, Mann, Douglas L., MD, Wang, Yun, PhD, Foody, JoAnne M., MD

“…Effective treatment to achieve target lipid parameters in high-risk patients may require combination drug therapies. Concerns regarding risks associated with…”
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MY APPROACH to the patient with memory loss who needs a statin by Watson, Karol E., MD, PhD, FACC, Sallam, Tamer, MD, PhD

“…[...]ASCVD risk reduction benefits may be seen within the first 2 years of beginning statin therapy. [...]if the patient has a reasonable quality of life and…”
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LncRNAs in Inflammation by Salisbury, David A., Kallapur, Aneesh, Repetti, Giuliana G., Fraga, Josue, Kim, Jason, Wu, Xiaohui, Sallam, Tamer

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Noggin depletion in adipocytes promotes obesity in mice by Blázquez-Medela, Ana M., Jumabay, Medet, Rajbhandari, Prashant, Sallam, Tamer, Guo, Yina, Yao, Jiayi, Vergnes, Laurent, Reue, Karen, Zhang, Li, Yao, Yucheng, Fogelman, Alan M., Tontonoz, Peter, Lusis, Aldons J., Wu, Xiuju, Boström, Kristina I.

“…Obesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic…”
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