Search Results - "Salji, Mark"

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer by Blomme, Arnaud, Ford, Catriona A., Mui, Ernest, Patel, Rachana, Ntala, Chara, Jamieson, Lauren E., Planque, Mélanie, McGregor, Grace H., Peixoto, Paul, Hervouet, Eric, Nixon, Colin, Salji, Mark, Gaughan, Luke, Markert, Elke, Repiscak, Peter, Sumpton, David, Blanco, Giovanny Rodriguez, Lilla, Sergio, Kamphorst, Jurre J., Graham, Duncan, Faulds, Karen, MacKay, Gillian M., Fendt, Sarah-Maria, Zanivan, Sara, Leung, Hing Y.

“…Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant…”
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A 5‑FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry In Vitro and In Vivo by Adam, Catherine, Bray, Thomas L, Pérez-López, Ana M, Tan, Ee Hong, Rubio-Ruiz, Belén, Baillache, Daniel J, Houston, Douglas R, Salji, Mark J, Leung, Hing Y, Unciti-Broceta, Asier

“…5-Fluorouracil (5-FU) is an antineoplastic antimetabolite that is widely administered to cancer patients by bolus injection, especially to those suffering from…”
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SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer by Martinez, Rafael S, Salji, Mark J, Rushworth, Linda, Ntala, Chara, Rodriguez Blanco, Giovanny, Hedley, Ann, Clark, William, Peixoto, Paul, Hervouet, Eric, Renaude, Elodie, Kung, Sonia H Y, Galbraith, Laura C A, Nixon, Colin, Lilla, Sergio, MacKay, Gillian M, Fazli, Ladan, Gaughan, Luke, Sumpton, David, Gleave, Martin E, Zanivan, Sara, Blomme, Arnaud, Leung, Hing Y

“…Androgen deprivation therapy (ADT) is the standard of care for treatment of nonresectable prostate cancer. Despite high treatment efficiency, most patients…”
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Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging by Freckmann, Eva C., Sandilands, Emma, Cumming, Erin, Neilson, Matthew, Román-Fernández, Alvaro, Nikolatou, Konstantina, Nacke, Marisa, Lannagan, Tamsin R. M., Hedley, Ann, Strachan, David, Salji, Mark, Morton, Jennifer P., McGarry, Lynn, Leung, Hing Y., Sansom, Owen J., Miller, Crispin J., Bryant, David M.

“…Single cell profiling by genetic, proteomic and imaging methods has expanded the ability to identify programmes regulating distinct cell states. The…”
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A contemporary analysis of disease upstaging of Gleason 3 + 3 prostate cancer patients after robot‐assisted laparoscopic prostatectomy by Taggart, Ruairidh, Dutto, Lorenzo, Leung, Hing Y., Salji, Mark, Ahmad, Imran

“…Background Risk of biochemical recurrence (BCR) in localised prostate cancer can be stratified using the 5‐tier Cambridge Prognostic Group (CPG) or 3‐tier…”
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BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration by Loveridge, Carolyn J., Slater, Sarah, Campbell, Kirsteen J., Nam, Noor A., Knight, John, Ahmad, Imran, Hedley, Ann, Lilla, Sergio, Repiscak, Peter, Patel, Rachana, Salji, Mark, Fleming, Janis, Mitchell, Louise, Nixon, Colin, Strathdee, Douglas, Neilson, Matthew, Ntala, Chara, Bryson, Sheila, Zanivan, Sara, Edwards, Joanne, Robson, Craig N., Goodyear, Carl S., Blyth, Karen, Leung, Hing Y.

“…BRF1 is a rate-limiting factor for RNA Polymerase III-mediated transcription and is elevated in numerous cancers. Here, we report that elevated levels of BRF1…”
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Gene Regulation Network Analysis on Human Prostate Orthografts Highlights a Potential Role for the JMJD6 Regulon in Clinical Prostate Cancer by Cangiano, Mario, Grudniewska, Magda, Salji, Mark J, Nykter, Matti, Jenster, Guido, Urbanucci, Alfonso, Granchi, Zoraide, Janssen, Bart, Hamilton, Graham, Leung, Hing Y, Beumer, Inès J

“…Prostate cancer (PCa) is the second most common tumour diagnosed in men. Tumoral heterogeneity in PCa creates a significant challenge to develop robust…”
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Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysis by Clement, Keiran, Day, Lizzy, Rooney, Helen, Neilson, Matt, Birrell, Fiona, Salji, Mark, Norman, Elizabeth, Clark, Ross, Patel, Amit, Morrison, John, Leung, Hing

“…Lack of investment for magnetic resonance (MR) fusion systems is an obstacle to deliver targeted prostate biopsies within the prostate cancer diagnostic…”
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Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1 by Patel, Rachana, Fleming, Janis, Mui, Ernest, Loveridge, Carolyn, Repiscak, Peter, Blomme, Arnaud, Harle, Victoria, Salji, Mark, Ahmad, Imran, Teo, Katy, Hamdy, Freddie C, Hedley, Ann, van den Broek, Niels, Mackay, Gillian, Edwards, Joanne, Sansom, Owen J, Leung, Hing Y

“…Metastatic castration‐resistant prostate cancer (mCRPC) is a lethal form of treatment‐resistant prostate cancer and poses significant therapeutic challenges…”
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Multi-omics & pathway analysis identify potential roles for tumor N-acetyl aspartate accumulation in murine models of castration-resistant prostate cancer by Salji, Mark J., Blomme, Arnaud, Däbritz, J. Henry M., Repiscak, Peter, Lilla, Sergio, Patel, Rachana, Sumpton, David, van den Broek, Niels J.F., Daly, Ronan, Zanivan, Sara, Leung, Hing Y.

“…Castration-resistant prostate cancer (CRPC) is incurable and remains a significant worldwide challenge (Oakes and Papa, 2015). Matched untargeted multi-level…”
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Gathering preliminary data by Winchester, Catherine L, Salji, Mark J, Kasivisvanathan, Veeru

“…Prior to any large-scale basic science or clinical research project being funded, it is important for researchers to gather preliminary data. This is essential…”
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Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis by Ntala, Chara, Salji, Mark, Salmond, Jonathan, Officer, Leah, Teodosio, Ana Vieira, Blomme, Arnaud, McGhee, Ewan J., Powley, Ian, Ahmad, Imran, Kruithof-de Julio, Marianna, Thalmann, George, Roberts, Ed, Goodyear, Carl S., Jamaspishvili, Tamara, Berman, David M., Carlin, Leo M., Le Quesne, John, Leung, Hing Y.

“…Pelvic nodal metastasis in prostate cancer impacts patient outcome negatively. To explore tumor-infiltrating immune cells as a potential predictive tool for…”
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THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer by Blomme, Arnaud, Peter, Coralie, Mui, Ernest, Rodriguez Blanco, Giovanny, An, Ning, Mason, Louise M, Jamieson, Lauren E, McGregor, Grace H, Lilla, Sergio, Ntala, Chara, Patel, Rachana, Thiry, Marc, Kung, Sonia H Y, Leclercq, Marine, Ford, Catriona A, Rushworth, Linda K, McGarry, David J, Mason, Susan, Repiscak, Peter, Nixon, Colin, Salji, Mark J, Markert, Elke, MacKay, Gillian M, Kamphorst, Jurre J, Graham, Duncan, Faulds, Karen, Fazli, Ladan, Gleave, Martin E, Avezov, Edward, Edwards, Joanne, Yin, Huabing, Sumpton, David, Blyth, Karen, Close, Pierre, Murphy, Daniel J, Zanivan, Sara, Leung, Hing Y

“…Despite the clinical benefit of androgen‐deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal…”
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Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer by Ahmad, Imran, Mui, Ernest, Galbraith, Laura, Patel, Rachana, Tan, Ee Hong, Salji, Mark, Rust, Alistair G., Repiscak, Peter, Hedley, Ann, Markert, Elke, Loveridge, Carolyn, van der Weyden, Louise, Edwards, Joanne, Sansom, Owen J., Adams, David J., Leung, Hing Y.

“…Prostate cancer (CaP) is the most common adult male cancer in the developed world. The paucity of biomarkers to predict prostate tumor biology makes it…”
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Bright insights into palladium-triggered local chemotherapy by Bray, Thomas L, Salji, Mark, Brombin, Alessandro, Pérez-López, Ana M, Rubio-Ruiz, Belén, Galbraith, Laura C A, Patton, E Elizabeth, Leung, Hing Y, Unciti-Broceta, Asier

“…The incorporation of transition metal catalysts to the bioorthogonal toolbox has opened the possibility of producing supra-stoichiometric amounts of…”
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Raman Spectroscopy in Prostate Cancer: Techniques, Applications and Advancements by Gaba, Fortis, Tipping, William J, Salji, Mark, Faulds, Karen, Graham, Duncan, Leung, Hing Y

“…Optical techniques are widely used tools in the visualisation of biological species within complex matrices, including biopsies, tissue resections and…”
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Phase II proof‐of‐concept study of atorvastatin in castration‐resistant prostate cancer by Rushworth, Linda K., Loveridge, Carolyn, Salji, Mark, MacLeod, Martin, Mui, Ernest, Sumpton, David, Neilson, Matthew, Hedley, Ann, Alexander, Laura, McCartney, Elaine, Patel, Rachana, Wallace, Jan, Delles, Christian, Jones, Rob, Leung, Hing Y.

“…Objectives To test for evidence of statin‐mediated effects in patients with castration‐resistant prostate cancer (CRPC) as post‐diagnosis use of statins in…”
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Writing a literature review by Winchester, Catherine L, Salji, Mark

“…Formal literature reviews are a critical appraisal of a subject and are not only an academic requirement but essential when planning a research project and for…”
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Effect of HER3 dimer feedback upregulation via PI3K-AKT-mTOR pathway inhibition on androgen receptor (AR) stabilization in metastatic prostate cancer by Galazi, Myria, Salji, Mark, Weitsman, Gregory, Gomez, Valentin, Leung, Hing, Ng, Tony

“…Abstract only 226 Background: Metastatic castration resistant prostate cancer (CRPC) is dependent on persistent activation of the AR. In addition, the AR and…”
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Peri-prostatic Fat Volume Measurement as a Predictive Tool for Castration Resistance in Advanced Prostate Cancer by Salji, Mark, Hendry, Jane, Patel, Amit, Ahmad, Imran, Nixon, Colin, Leung, Hing Y

“…Abstract Background Obesity and aggressive prostate cancer (PC) may be linked, but how local peri-prostatic fat relates to tumour response following androgen…”
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