Acute sublethal exposure to ethiprole impairs physiological and oxidative status in the Neotropical fish Astyanax altiparanae

Ethiprole, a phenylpyrazole insecticide, has been increasingly used in the Neotropical region to control stink bug pests in soybean and maize fields. However, such abrupt increases in use may have unintended effects on non-target organisms, including those inhabiting freshwater ecosystems. Here, we...

Full description

Saved in:

Bibliographic Details
Published in:	Environmental pollution (1987) Vol. 334; p. 122152
Main Authors:	Salaro, Ana Lúcia, Silva, Stella B., Ferraz, Renato B., Salinas Jiménez, Luis G., Carneiro, Cristiana L.S., Quadros, Alessandro S.G., Machado, João Paulo, Freitas, Mariella B., Oliveira, Eugênio E.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-10-2023
Subjects:	Non-target organisms Oxidative stress responses Phenylpyrazoles Undesired effects Unintended exposures Unintended exposures Non-target organisms Phenylpyrazoles Undesired effects Oxidative stress responses
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Ethiprole, a phenylpyrazole insecticide, has been increasingly used in the Neotropical region to control stink bug pests in soybean and maize fields. However, such abrupt increases in use may have unintended effects on non-target organisms, including those inhabiting freshwater ecosystems. Here, we evaluated the effects of acute (96 h) sublethal exposure to ethiprole (up to 180 μg/L, which is equivalent to 0.013% of the recommended field dose) on biomarkers of stress in the gills, liver, and muscle of the Neotropical fish Astyanax altiparanae. We further recorded potential ethiprole-induced effects on the structural histology of A. altiparanae gills and liver. Our results showed that ethiprole exposure increased glucose and cortisol levels in a concentration-dependent manner. Ethiprole-exposed fish also exhibited higher levels of malondialdehyde and greater activity of antioxidant enzymes, such as glutathione-S-transferase and catalase, in both gills and liver. Furthermore, ethiprole exposure led to increased catalase activity and carbonylated protein levels in muscle. Morphometric and pathological analyses of the gills revealed that increasing ethiprole concentration resulted in hyperemia and loss of integrity of the secondary lamellae. Similarly, histopathological analysis of the liver demonstrated higher prevalence of necrosis and inflammatory infiltrates with increasing ethiprole concentration. Altogether, our findings demonstrated that sublethal exposure to ethiprole can trigger a stress response in non-target fish species, which may lead to potential ecological and economic imbalances in Neotropical freshwater systems. [Display omitted] •Ethiprole-exposed (96h) Astyanax altiparanae exhibited impaired antioxidant status.•Ethiprole-exposed A. altiparanae further showed gills and liver lipid peroxidation.•Ethiprole exposures structurally damaged the gills and liver tissues.•Sublethal ethiprole exposures harm the stress status of Neotropical freshwater fish.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0269-7491 1873-6424
DOI:	10.1016/j.envpol.2023.122152