Human Immunodeficiency Virus Infection in the US Air Force: Seroconversions, Clinical Staging, and Assessment of a T Helper Cell Functional Assay to Predict Change in CD4+ T Cell Counts

Human Immunodeficiency Virus Infection in the US Air Force: Seroconversions, Clinical Staging, and Assessment of a T Helper Cell Functional Assay to Predict Change in CD4+ T Cell Counts

As of January 1990, 933 persons with human immunodeficiency virus type 1 (HIV-l) infection were clinically evaluated at Wilford Hall US Air Force (USAF) Medical Center. The Walter Reed HIV staging system was used in these evaluations to describe disease status and progression. Most persons were diag...

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Bibliographic Details
Published in:The Journal of infectious diseases Vol. 164; no. 4; pp. 631 - 637
Main Authors: Lucey, Daniel R., Melcher, Gregory P., Hendrix, Craig W., Zajac, Robert A., Goetz, David W., Butzin, Clifford A., Clerici, Mario, Warner, Ronald D., Abbadessa, Steven, Hall, Kevin, Jaso, Rene, Woolford, Brian, Miller, Shirley, Stocks, Naomi I., Salinas, Cynthia M., Wolfe, William H., Shearer, Gene M., Boswell, R. Neal
Format: Journal Article
Language:English
Published: Chicago, IL The University of Chicago Press 01-10-1991
University of Chicago Press
Subjects:
Adult
AIDS
AIDS/HIV
Air forces
Analysis of Variance
Antibodies
Biological and medical sciences
CD4-Positive T-Lymphocytes - cytology
Female
Functional groups
HIV
HIV 1
HIV infections
HIV Infections - epidemiology
HIV Infections - immunology
HIV Seropositivity - epidemiology
Humans
Infections
Infectious diseases
Leukocyte Count
Major Articles
Male
Medical sciences
Military Personnel
Opportunistic Infections - epidemiology
Prognosis
Prospective Studies
T lymphocytes
T-Lymphocytes, Helper-Inducer - cytology
United States
Viral diseases
Viruses
United States
Human
Immunopathology
Retroviridae
AIDS
Cellular immunity
Serology
Infection
Virus
Viral disease
T-Lymphocyte
Lentivirinae
Clinical investigation
Diagnosis
Human immunodeficiency virus
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Description
Summary:As of January 1990, 933 persons with human immunodeficiency virus type 1 (HIV-l) infection were clinically evaluated at Wilford Hall US Air Force (USAF) Medical Center. The Walter Reed HIV staging system was used in these evaluations to describe disease status and progression. Most persons were diagnosed through mandatory HIV testing in the USAF and were asymptomatic at the time of diagnosis. As of May 1990, 161 HIV-positive seroconverters (estimated overall seroconversion rate of 0.156/1000 person-years between 30 June 1988 and 1 July 1990) had been identified among active-duty USAF personnel, as they had previously tested negative for antibody to HIV. Men constitute 95% of the USAF HIV-positive population. An in vitro T helper cell functional assay was assessed to predict rate of CD4+ T cell decline over the subsequent year (mean, 15 months) in patients with >200 CD4+ T cells/mm3, This assay may prove useful for prognostication and comparisons of patients in clinical trials of anti-HIV interventions.
Bibliography:Reprints or correspondence (*present address): Maj. Daniel R. Lucey, Department of Retroviral Research, Walter Reed Army Institute of Research, 13 Taft Court. Suite 200, Rockville. MD 20850.
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ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/164.4.631