Search Results - "Salinas, Cristian A."

Combining PET Biodistribution and Equilibrium Dialysis Assays to Assess the Free Brain Concentration and BBB Transport of CNS Drugs by Gunn, Roger N, Summerfield, Scott G, Salinas, Cristian A, Read, Kevin D, Guo, Qi, Searle, Graham E, Parker, Christine A, Jeffrey, Phil, Laruelle, Marc

“…The passage of drugs in and out of the brain is controlled by the blood—brain barrier (BBB), typically, using either passive diffusion across a concentration…”
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The Simplified Reference Tissue Model: Model Assumption Violations and Their Impact on Binding Potential by Salinas, Cristian A, Searle, Graham E, Gunn, Roger N

“…Reference tissue models have gained significant traction over the last two decades as the methods of choice for the quantification of brain positron emission…”
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Synthesis and in vivo evaluation of [11C]BU99008 as a ligand for the imidazoline I2 binding site by Kealey, Steven, Husbands, Stephen, Casey, Emma M., Salinas, Cristian A., Parker, Christine A., Jakobsen, Steen, Tyacke, Robin J., Nutt, David J., Gee, Antony D.

“…Background: Imidazoline-2 binding sites (I2BS) are thought to be mainly located on glial cells, and have prompted interest in neurodegenerative and…”
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Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with 18 F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles by Lohith, Talakad G, Bennacef, Idriss, Vandenberghe, Rik, Vandenbulcke, Mathieu, Salinas, Cristian A, Declercq, Ruben, Reynders, Tom, Telan-Choing, N Florestina, Riffel, Kerry, Celen, Sofie, Serdons, Kim, Bormans, Guy, Tsai, Kuenhi, Walji, Abbas, Hostetler, Eric D, Evelhoch, Jeffrey L, Van Laere, Koen, Forman, Mark, Stoch, Aubrey, Sur, Cyrille, Struyk, Arie

“…F-MK-6240 ( F-labeled 6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine) is a highly selective, subnanomolar-affinity PET tracer for imaging…”
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Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy by Abanades, Sergio, van der Aart, Jasper, Barletta, Julien AR, Marzano, Carmine, Searle, Graham E, Salinas, Cristian A, Ahmad, Javaad J, Reiley, Richard R, Pampols-Maso, Sabina, Zamuner, Stefano, Cunningham, Vincent J, Rabiner, Eugenii A, Laruelle, Marc A, Gunn, Roger N

“…Positron emission tomography (PET) is used in drug development to assist dose selection and to establish the relationship between blood and tissue…”
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Spatio-temporal pharmacokinetic model based registration of 4D PET neuroimaging data by Jiao, Jieqing, Searle, Graham E., Tziortzi, Andri C., Salinas, Cristian A., Gunn, Roger N., Schnabel, Julia A.

“…In dynamic positron emission tomography (PET) neuroimaging studies, where scan durations often exceed 1h, registration of motion-corrupted dynamic PET images…”
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Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography by Comley, Robert A, Salinas, Cristian A, Slifstein, Mark, Petrone, Marcella, Marzano, Carmine, Bennacef, Idriss, Shotbolt, Paul, Van der Aart, Jasper, Neve, Marta, Iavarone, Laura, Gomeni, Roberto, Laruelle, Marc, Gray, Frank A, Gunn, Roger N, Rabiner, Eugenii A

“…The selection of a therapeutically meaningful dose of a novel pharmaceutical is a crucial step in drug development. Positron emission tomography (PET) allows…”
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DISCOVERY AND FIRST-IN-HUMAN EVALUATION OF THE TAU-IMAGING PET RADIOTRACER [18 F]MK-6240 by Bennacef, Idriss, Zeng, Zhizhen, Lohith, Talakad, Miller, Patricia J, Salinas, Cristian A, Connolly, Brett M, Gantert, Liza T, Haley, Hyking D, Marie, Holahan A, O’Malley, Stacey S, Purcell, Mona L, Riffel, Kerry, Coleman, Paul J, Li, Jing, Balsells-Padros, Jaume, Soriano, Aileen, Ogawa, Aimie M, Xu, Serena, Xiaoping, Zhang, Della Rocca, Joseph, Schachter, Joel B, Hesk, David, David, Schenk J, Telan-Choing, Florestina, Struyk, Arie, Sur, Cyrille, Celen, Sofie, Serdons, Kim, Bormans, Guy, Vandenbulcke, Mathieu, Vandenberghe, Rik, De Hoon, Jan, Koole, Michel, Van Laere, Koen, Declercq, Ruben, Tom, Reynders, Abbas, Walji, Eric, Hostetler D, Evelhoch, Jeffrey

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DISCOVERY AND FIRST-IN-HUMAN EVALUATION OF THE TAU-IMAGING PET RADIOTRACER [18 F]MK-6240 by Bennacef, Idriss, Zeng, Zhizhen, Lohith, Talakad, Miller, Patricia J, Salinas, Cristian A, Connolly, Brett M, Gantert, Liza T, Hyking, Haley D, Holahan, Marie A, O’Malley, Stacey S, Purcell, Mona L, Riffel, Kerry, Coleman, Paul J, Li, Jing, Balsells-Padros, Jaume, Soriano, Aileen, Ogawa, Aimie M, Xu, Serena, Xiaoping, Zhang, Della Rocca, Joseph, Schachter, Joel B, Hesk, David, Telan-Choing, Florestina, Struyk, Arie, Sur, Cyrille, Celen, Sofie, Serdons, Kim, Bormans, Guy, Vandenbulcke, Mathieu, Vandenberghe, Rik, De Hoon, Jan, Koole, Michel, Van Laere, Koen, Declercq, Ruben, Reynders, Tom, Abbas, Walji, Hostetler, Eric D, Evelhoch, Jeffrey

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Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies by BENNACEF, Idriss, SALINAS, Cristian A, HOLMES, Ian, MICHELI, Fabrizio, HEIDBREDER, Christian, GENTILE, Gabriella, ROSSI, Tino, LARUELLE, Marc, BONASERA, Thomas A, GUNN, Roger N, AUDRAIN, Hélène, JAKOBSEN, Steen, NABULSI, Nabeel, WEINZIMMER, David, CARSON, Richard E, YIYUN HUANG

“…Compound 1 is a potent and selective antagonist of the dopamine D(3) receptor. With the aim of developing a carbon-11 labeled ligand for the dopamine D(3)…”
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Pharmacokinetic characterization of compounds with increased target residence times using PET by Salinas, Cristian A., Weinzimmer, David P., Searle, Graham, Labaree, David, Ding, Yu-Shin, Huang, Yiyun, Rabiner, Eugenii A., Carson, Richard E., Gunn, Roger N.

“…[...]for compounds with an increased target residence time (TRT) an Indirect model is required that dynamically relates the plasma concentration time course to…”
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Advances in biomathematical modeling for PET neuroreceptor imaging by Gunn, Roger N., Guo, Qi, Salinas, Cristian A., Tziortzi, Andri C., Searle, Graham E.

“…The quantitative application of PET neuroreceptor imaging to study pathophysiology, diagnostics and drug development has continued to benefit from associated…”
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11C-GSK189254: A Selective Radioligand for In Vivo Central Nervous System Imaging of Histamine H3 Receptors by PET by Plisson, Christophe, Gunn, Roger N, Cunningham, Vincent J, Bender, Dirk, Salinas, Cristian A, Medhurst, Andrew D, Roberts, Jennifer C, Laruelle, Marc, Gee, Antony D

“…The histamine H(3) receptor is a G-protein-coupled presynaptic auto- and heteroreceptor whose activation leads to a decrease in the release of several…”
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Validity of model approximations for receptor-ligand kinetics in nuclear medicine by Salinas, Cristian A., Muzic, Raymond F., Saidel, Gerald M.

“…An appropriate mathematical model is required for quantitative analysis of high affinity radioligands as direct or surrogate probes to measure receptor…”
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A Visual Interpretation Algorithm for Assessing Brain Tauopathy with [18F]MK6240 Positron Emission Tomography by DuBois, Jonathan M, Seibyl, John, Racine, Annie M, Collins, Jessica A., Martarello, Laurent, Salinas, Cristian A

“…Background In vivo characterization of pathologic deposition of tau protein in the human brain by PET imaging is a promising tool in drug development trials in…”
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LONGITUDINAL ASSESSMENT OF TAU WITH [18F]MK-6240 IN ALZHEIMER’S DISEASE PATIENTS AND COGNITIVELY NORMAL ADULTS AT 6 AND 12 MONTHS by Salinas, Cristian A., Purohit, Ajay, Beaver, John, Martarello, Laurent

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IC‐P‐176: LONGITUDINAL ASSESSMENT OF TAU WITH [18F]MK‐6240 IN ALZHEIMER'S DISEASE PATIENTS AND COGNITIVELY NORMAL ADULTS AT 6 AND 12 MONTHS by Salinas, Cristian A., Purohit, Ajay, Beaver, John, Martarello, Laurent

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Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with ^sup 18^F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles by Lohith, Talakad G, Bennacef, Idriss, Vandenberghe, Rik, Vandenbulcke, Mathieu, Salinas, Cristian A, Celen, Sofie, Hostetler, Eric D, Struyk, Arie, man, Mark, Sur, Cyrille, Van Laere, Koen, Serdons, Kim, Riffel, Kerry, Bormans, Guy, Telan-Choing, N Florestina, Stoch, Aubrey, Reynders, Tom, Evelhoch, Jeffrey L, Declercq, Ruben, Tsai, Kuenhi, Walji, Abbas

“…18F-MK-6240 (18F-labeled 6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine) is a highly selective, subnanomolar-affinity PET tracer for imaging…”
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Imaging Imidazoline-I^sub 2^ Binding Sites in Porcine Brain Using ^sup 11^C-BU99008 by Kealey, Steven, Turner, Emma M, Husbands, Stephen M, Salinas, Cristian A, Jakobsen, Steen, Tyacke, Robin J, Nutt, David J, Parker, Christine A, Gee, Antony D

“…Changes in the density of imidazoline-... binding sites have been observed in a range of neurologic disorders including Alzheimer's disease, Huntington's…”
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Imaging Imidazoline-I 2 Binding Sites in Porcine Brain Using 11 C-BU99008 by Kealey, Steven, Turner, Emma M., Husbands, Stephen M., Salinas, Cristian A., Jakobsen, Steen, Tyacke, Robin J., Nutt, David J., Parker, Christine A., Gee, Antony D.

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