Search Results - "Salimath, Bharathi P."

A new pyrrole based small molecule from Tinospora cordifolia induces apoptosis in MDA-MB-231 breast cancer cells via ROS mediated mitochondrial damage and restoration of p53 activity by Rashmi, K.C., Harsha Raj, M., Paul, Manoj, Girish, Kesturu S., Salimath, Bharathi P., Aparna, H.S.

“…Approximately 15% of globally diagnosed breast cancers are designated as triple negative breast cancer (TNBC). In this study, we investigated the effect of the…”
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Vascular Endothelial Growth Factor Receptor, fms-Like Tyrosine Kinase-1 (Flt-1), as a Novel Binding Partner for SARS-CoV-2 Spike Receptor-Binding Domain by Mutahar, Adel Zaid I., Devaramani, Manjunath, Dayal, Renu, Saini, Dinesh Kumar, Salimath, Paramahans V., Salimath, Bharathi P.

“…Angiotensin-converting enzyme 2 (ACE2) and neuropilin 1, a vascular endothelial growth factor (VEGF) receptor, were identified to bind to the SARS-CoV-2 spike…”
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Characterization and Cytotoxicity of Pseudomonas Mediated Rhamnolipids Against Breast Cancer MDA-MB-231 Cell Line by Mishra, Neelam, Rana, Kavita, Seelam, Siva Deepthi, Kumar, Rakesh, Pandey, Vijyendra, Salimath, Bharathi P, Agsar, Dayanand

“…A biosurfactant producing bacterium was identified as DNM50 based on molecular characterization (NCBI accession no. MK351591). Structural characterization…”
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Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF- B and its DNA binding activity by Thippeswamy, G., Sheela, M.L., Salimath, Bharathi P.

“…Octacosanol is a long-chain aliphatic alcohol, which is the main component of policosanol used as a normolipidemic agent. It is known that angiogenesis is…”
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Suppression of VEGF-induced angiogenesis and tumor growth by Eugenia jambolana, Musa paradisiaca, and Coccinia indica extracts by M., Harsha Raj, Ghosh, Debidas, Banerjee, Rita, Salimath, Bharathi P.

“…Context: Abnormal angiogenesis and evasion of apoptosis are hallmarks of cancer. Accordingly, anti-angiogenic and pro-apoptotic therapies are effective…”
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Molecular mechanisms of anti-angiogenic effect of curcumin by Gururaj, Anupama E, Belakavadi, Madesh, Venkatesh, Deepak A, Marmé, Dieter, Salimath, Bharathi P

“…Modulation of pathological angiogenesis by curcumin (diferuloylmethane), the active principle of turmeric, seems to be an important possibility meriting…”
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Synthesis and Screening of Pro-apoptotic and Angio-inhibitory Activity of Novel Benzisoxazole Derivatives both In Vitro and In Vivo by Byrappa, Sathish, Rachaiah, Kavitha, Kotian, Sumana Y, Balaraju, Yashaswini, Prabhuswamimath, Samudyata C, Rai, Kuriya M L, Salimath, Bharathi P

“…Triple Negative Breast Cancer (TNBC) tends to be more aggressive than other types of breast cancer. Resistance to chemotherapy is a major obstacle hence there…”
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Anti-metastatic action of anacardic acid targets VEGF-induced signalling pathways in epithelial to mesenchymal transition by Shilpa, Puttananjaiah, Kaveri, Keshavaiah, Salimath, Bharathi P

“…Anacardic acid is a major constituent of nutshell of cashew. In this study, we have isolated it from the leaves of Anacardium Occidentale L. using…”
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Angiogenic and proliferative effects of the cytokine VEGF in Ehrlich ascites tumor cells is inhibited by Glycyrrhiza glabra by Sheela, M.L., Ramakrishna, M.K., Salimath, Bharathi P.

“…Blood vessel plays a crucial role in solid tumor development. It has been suggested that blocking of angiogenesis and the action of the cytokine VEGF could be…”
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pro-apoptotic 15-kDa protein from Bacopa monnieri activates caspase-3 and downregulates Bcl-2 gene expression in mouse mammary carcinoma cells by Kalyani, Manjula Ishwara, Lingaraju, Sheela Mysore, Salimath, Bharathi P

“…In diseases such as cancer, induction of apoptosis has been a new target for mechanism-based drug discovery. The central component of the process of apoptosis…”
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Evaluation of serum vascular endothelial growth factor (VEGF) and microvessel density (MVD) as prognostic indicators in carcinoma breast by Shivakumar, S, Prabhakar, B. T, Jayashree, K, Rajan, M. G. R, Salimath, Bharathi P

“…Purpose Vascular endothelial growth factor (VEGF) is a potent angiogenic peptide. A great deal of interest has been paid to the predictive value of…”
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Combinatorial treatment with anacardic acid followed by TRAIL augments induction of apoptosis in TRAIL resistant cancer cells by the regulation of p53, MAPK and NFκβ pathways by Harsha Raj, M., Yashaswini, B., Rössler, Jochen, Salimath, Bharathi P.

“…TRAIL, an apoptosis inducing cytokine currently in phase II clinical trial, was investigated for its capability to induce apoptosis in six different human…”
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Combinatorial treatment with anacardic acid followed by TRAIL augments induction of apoptosis in TRAIL resistant cancer cells by the regulation of p53, MAPK and NF Kappa beta pathways by Harsha Raj, M, Yashaswini, B, Rossler, Jochen, Salimath, Bharathi P

“…TRAIL, an apoptosis inducing cytokine currently in phase II clinical trial, was investigated for its capability to induce apoptosis in six different human…”
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Crosstalk between VEGF and MTA1 signaling pathways contribute to aggressiveness of breast carcinoma by Nagaraj, Sachin Raj M., Shilpa, Puttananjaiah, Rachaiah, Kavitha, Salimath, Bharathi P.

“…The expression of metastasis associated protein (MTA1) correlates well with tumor metastasis; however its role as a proangiogenic protein and the molecular…”
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Synthesis and biological evaluation of novel isoxazolines linked via piperazine to 2- benzoisothiazoles as potent apoptotic agents by Byrappa, Sathish, Harsha Raj, M., Kungyal, Tenzin, Kudva N, Narayana U., Salimath, Bharathi P., Lokanatha Rai, K.M.

“…Synthesis of 3-(4-((3-Phenyl-4,5-dihydroisoxazol-5-yl)methyl)piperazin-1-yl) benzoisothiazole derivatives (5a-i), which constitute a new class of isoxazolines,…”
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A pyrrole-based natural small molecule mitigates HSP90 expression in MDA-MB-231 cells and inhibits tumor angiogenesis in mice by inactivating HSF-1 by Rashmi, K. C., Atreya, H. S., Raj, M. Harsha, Salimath, Bharathi P., Aparna, H. S.

“…Heat shock proteins (HSPs), molecular chaperones, are crucial for the cancer cells to facilitate proper functioning of various oncoproteins involved in cell…”
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Crosstalk between VEGF and novel angiogenic protein regulates tumor angiogenesis and contributes to aggressiveness of breast carcinoma by Belugali Nataraj, Nishanth, Salimath, Bharathi P.

“…We have identified and characterized a novel proangiogenic glycoprotein (NAP) with molecular weight of 67kDa from synovial fluid of rheumatoid arthritis…”
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Role of pesticides in the induction of tumor angiogenesis by Bharathi, Salimath P, Raj, Harsh M, Jain, Smita, Banerjee, Basu Dev, Ahmed, Tanzeel, Arora, Vinod Kumar

“…Due to their estrogen-mimicking ability, pesticides are considered as prime etiological suspects of increasing tumor incidence, although a direct link is still…”
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Buffalo Colostrum β-lactoglobulin Inhibits VEGF-Induced Angiogenesis by Interacting with G protein-Coupled Receptor Kinase by Chougule, Rohit A., P., Shilpa, Salimath, Bharathi P., Sosalegowda, Aparna H.

“…β-lactoglobulin (β-lg), a major whey protein was purified and characterised from buffalo colostrum. The in silico analysis of the tryptic peptides based on…”
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Platelet-derived growth factor receptor signaling is not involved in osteogenic differentiation of human mesenchymal stem cells by Kumar, Akhilesh, Salimath, Bharathi P, Stark, Gerhard Björn, Finkenzeller, Günter

“…Platelet-derived growth factor (PDGF) receptor signaling plays an important role in the regulation of proliferation and migration of skeletal cells such as…”
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