The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma

The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma

Background. The most common malignant tumor of the urinary bladder is transitional cell carcinoma (TCC). Neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9) is found to be a cell adhesion mediator. P38 Mitogen-Activated Protein Kinase is a serine/threonine kinases member...

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Bibliographic Details
Published in:Journal of Oncology Vol. 2017; no. 2017; pp. 1 - 9-006
Main Authors: Abdel Wahab, Khaled M., Abdelaziz, Lobna A., Abdelbary, Abeer M., El Shorbagy, Shereen, Ali, Maged M., Haggag, Rasha, Harb, Ola A., Salim, Reham A.
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Limiteds 01-01-2017
Hindawi Publishing Corporation
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Antibodies
Bladder cancer
Cell adhesion & migration
Cell cycle
Cloning
Gene expression
Genetic aspects
Kinases
Lymphatic system
Males
Medical prognosis
Metastasis
Physiological aspects
Prognosis
Protein kinases
Proteins
Tumors
Egypt
United Kingdom > UK
United States > US
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Summary:Background. The most common malignant tumor of the urinary bladder is transitional cell carcinoma (TCC). Neural precursor cell-expressed developmentally downregulated protein 9 (NEDD9) is found to be a cell adhesion mediator. P38 Mitogen-Activated Protein Kinase is a serine/threonine kinases member which can mediate carcinogenesis through intracellular signaling. Methods. To assess their prognostic role; NEDD9 and p38 protein were evaluated in sections from 50 paraffin blocks of TCC. Results. The high expressions of NEDD9 and p38 protein were significantly associated with grade, stage, distant metastasis (p<0.001), number of tumors, lymph node metastasis, and tumor size (p<0.001, 0.002; 0.018, <0.001; and 0.004, 0.007, respectively). High NEDD9 and p38 detection had a worse 3-year OS (p=0.041 and <0.001, respectively). By multivariate analysis the NEDD9 and p38 protein expression levels and various clinicopathological criteria including gender, grade, stage of the tumor, and regional lymph node involvement were independent prognostic parameters of TCC of the urinary bladder patients’ outcome. Conclusion. NEDD9 and p38 protein expressions were poor prognostic markers of TCC.
Bibliography:ObjectType-Article-1
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Academic Editor: Akira Hara
ISSN:1687-8450
1687-8450
DOI:10.1155/2017/6095205