Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study

Background: We evaluated the role of hyperhomocysteinemia as a risk factor for retinal vein occlusion (RVO) in Indian patients. Type of Study: Matched case control type of longitudinal study was conducted in 2006-2007. Materials and Methods: Two medical retina specialists examined the eyes having an...

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Published in:	Indian journal of ophthalmology Vol. 62; no. 3; pp. 291 - 294
Main Authors:	Al Wadani, Fahad, Khandekar, Rajiv, Salim, Gigani, Al Ali, Mohammed, Ramzi, Salman
Format:	Journal Article
Language:	English
Published:	India Medknow Publications 01-03-2014 Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Medknow Publications & Media Pvt Ltd Wolters Kluwer Medknow Publications
Subjects:	Adolescent Adult Age Atherosclerosis Central retinal vein occlusion Clinical profile Confidence intervals Contrast sensitivity Decompression of the orbit Diabetes diplopia Female fixation Fluorescein Angiography Follow-Up Studies Fundus Oculi Health aspects Health risk assessment Homocysteine Homocysteine - blood Homocysteine - urine Humans Hyperhomocysteinemia - complications Hyperhomocysteinemia - diagnosis Hyperhomocysteinemia - metabolism Hypertension Incidence India - epidemiology Indian population intravitrealbevacizumab intravitrealtriamcinolone acetonide Limbus incision macular edema Male Medical personnel microperimeter Middle Aged Normal distribution normative data Ophthalmoscopy optic disc pit optic neuritis optic neuritis treatment trial Optical coherence tomography orbit Original retinal detachment Retinal diseases retinal sensitivity retinal vein occlusion Retinal Vein Occlusion - diagnosis Retinal Vein Occlusion - epidemiology Retinal Vein Occlusion - etiology retinoschisis Retrospective Studies Risk Assessment - methods Risk Factors Studies subconjunctival incision sutureless manual small-incision cataract surgery thyroid exophthalmos thyroid ophthalmopathy Veins & arteries visual impairment wound construction Young Adult India retinal vein occlusion visual impairment Homocysteine
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Summary:	Background: We evaluated the role of hyperhomocysteinemia as a risk factor for retinal vein occlusion (RVO) in Indian patients. Type of Study: Matched case control type of longitudinal study was conducted in 2006-2007. Materials and Methods: Two medical retina specialists examined the eyes having an event of RVO in the last 15 days. A similar number of eyes without RVO were also examined. The serum and urine homocysteine levels of these persons were tested. Matched pair analysis was carried out to determine the risk of RVO among those with hyperhomocysteinemia. Results: We included 20 cases of RVO and 20 age- and sex-matched persons without RVO. The risk of RVO was significantly higher in persons with hyperhomocysteinemia [difference of mean 31.62 μmol/L (95% Confidence Interval 16.60-47 . 86), P = 2.1 × 10−13 ]. The mean urine homocysteine level among cases and controls was not statistically significant. There were 12 persons with hypertension in both cases and control groups. Conclusion: Hyperhomocysteinemia is a risk factor for RVO. Any list of investigations for a case of RVO should include total plasma homocysteine (tHcy) levels.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0301-4738 1998-3689
DOI:	10.4103/0301-4738.111213