Search Results - "Salido, G. M."

Homocysteine, intracellular signaling and thrombotic disorders by Dionisio, N, Jardín, I, Salido, G M, Rosado, J A

“…Homocysteine, a sulphur-containing amino acid derived from methionine, has been presented as an independent risk factor for cardiovascular disorders, including…”
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Membrane of the Mammalian Spermatozoa: Much More Than an Inert Envelope by Tapia, JA, Macias‐Garcia, B, Miro‐Moran, A, Ortega‐Ferrusola, C, Salido, GM, Peña, FJ, Aparicio, IM

“…Sperm plasma membrane is a very important structure that functions to protect sperm against extracellular injuries and to respond to physiological challenges…”
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Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation by Diez-Bello, R., Jardin, I., Salido, G.M., Rosado, J.A.

“…Store-operated Ca2+ entry (SOCE) is a major mechanism for the regulation of intracellular Ca2+ homeostasis and cellular function. Emerging evidence has…”
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Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility by Aparicio, I. M., Espino, J., Bejarano, I., Gallardo-Soler, A., Campo, M. L., Salido, G. M., Pariente, J. A., Peña, F. J., Tapia, J. A.

“…Macroautophagy (hereafter autophagy) is an evolutionarily highly conserved cellular process that participates in the maintenance of intracellular homeostasis…”
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(−)‑Oleocanthal inhibits proliferation and migration by modulating Ca2+ entry through TRPC6 in breast cancer cells by Diez-Bello, R., Jardin, I., Lopez, J.J., El Haouari, M., Ortega-Vidal, J., Altarejos, J., Salido, G.M., Salido, S., Rosado, J.A.

“…Triple negative breast cancer is an aggressive type of cancer that does not respond to hormonal therapy and current therapeutic strategies are accompanied by…”
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Cinnamtannin B-1 from bay wood exhibits antiapoptotic effects in human platelets by Bouaziz, A, Romera-Castillo, C, Salido, S, Linares-Palomino, P. J, Altarejos, J, Bartegi, A, Rosado, J. A, Salido, G. M

“…Proanthocyanidins, such as cinnamtannin B-1, are polyphenolic compounds with antioxidant activity that induce apoptosis in a number of tumoral cells. We have…”
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Identification of Apoptotic Bodies in Equine Semen by Caselles, AB, Miro‐Moran, A, Morillo Rodriguez, A, Gallardo Bolaños, JM, Ortega‐Ferrusola, C, Salido, GM, Peña, FJ, Tapia, JA, Aparicio, IM

“…Apoptosis in the testis is required to ensure an efficient spermatogenesis. However, sometimes, defective germ cells that are marked for elimination during…”
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TMEM97 facilitates the activation of SOCE by downregulating the association of cholesterol to Orai1 in MDA-MB-231 cells by Cantonero, C., Camello, P.J., Salido, G.M., Rosado, J.A., Redondo, P.C.

“…The expression of TMEM97, a regulator of cholesterol transport, has been reported to be enhanced in some tumour cells. We have recently shown that TMEM97 is…”
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Relationship between calcium mobilization and platelet α- and δ-granule secretion. A role for TRPC6 in thrombin-evoked δ-granule exocytosis by Lopez, E., Bermejo, N., Berna-Erro, A., Alonso, N., Salido, G.M., Redondo, P.C., Rosado, J.A.

“…Changes in cytosolic Ca2+ concentration ([Ca2+]c) regulate granule secretion in different cell types. Thrombin activates PAR1 and PAR4 receptors and promotes…”
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Release of calcium from mitochondrial and nonmitochondrial intracellular stores in mouse pancreatic acinar cells by hydrogen peroxide by Pariente, J A, Camello, C, Camello, P J, Salido, G M

“…In the present study we have studied how [Ca2+](i) is influenced by H2O2 in collagenase-dispersed mouse pancreatic acinar cells and the mechanism underlying…”
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The autophagy-related protein LC3 is processed in stallion spermatozoa during short-and long-term storage and the related stressful conditions by Aparicio, I. M., Martin Muñoz, P., Salido, G. M., Peña, F. J., Tapia, J. A.

“…Use of cooled and frozen semen is becoming increasingly prevalent in the equine industry. However, these procedures cause harmful effects in the sperm cell…”
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Thrombin induces apoptotic events through the generation of reactive oxygen species in human platelets by LOPEZ, J. J., SALIDO, G. M., GÓMEZ‐ARTETA, E., ROSADO, J. A., PARIENTE, J. A.

“…Background: Thrombin is a major physiological platelet agonist that activates a number of cell functions including aggregation. Platelet stimulation with…”
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Thrombin induces activation and translocation of Bid, Bax and Bak to the mitochondria in human platelets by LOPEZ, J. J., SALIDO, G. M., PARIENTE, J. A., ROSADO, J. A.

“…Background: Thrombin is a physiological platelet agonist that activates apoptotic events, including cytochrome c release and phosphatidylserine exposure;…”
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Sequential activation of different Ca2+ entry pathways upon cholinergic stimulation in mouse pancreatic acinar cells by Camello, C., Pariente, J. A., Salido, G. M., Camello, P. J.

“…We have studied capacitative calcium entry (CCE) under different experimental conditions in fura-2-loaded mouse pancreatic acinar cells by digital microscopic…”
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Identification of Protein Tyrosine Phosphatases and Dual-Specificity Phosphatases in Mammalian Spermatozoa and Their Role in Sperm Motility and Protein Tyrosine Phosphorylation by González-Fernández, L, Ortega-Ferrusola, C, Macias-Garcia, B, Salido, G.M, Peña, F.J, Tapia, J.A

“…Protein tyrosine kinases have important roles in spermatozoa; however, little is known about the presence and regulation in these cells of their counterparts…”
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STIM1, Orai1 and hTRPC1 are important for thrombin- and ADP-induced aggregation in human platelets by Galán, C., Zbidi, H., Bartegi, A., Salido, G.M., Rosado, J.A.

“…Ca 2+ entry, particularly store-operated Ca 2+ entry (SOCE), has been reported to be crucial for a variety of cellular functions. SOCE is a mechanism regulated…”
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Functional role of the calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) site of TRPC6 in human platelet activation by Dionisio, N., Albarran, L., Berna-Erro, A., Hernandez-Cruz, J.M., Salido, G.M., Rosado, J.A.

“…All identified mammalian TRPC channels show a C-terminal calmodulin (CaM)- and inositol 1,4,5-trisphosphate receptors (IP 3Rs)-binding (CIRB) site involved in…”
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Collaborative effect of SERCA and PMCA in cytosolic calcium homeostasis in human platelets by Redondo, P C, Rosado, J A, Pariente, J A, Salido, G M

“…Intracellular free Ca2+ concentration ([Ca2+]c) is finely regulated by several mechanisms that either increase or reduce [Ca2+]c. Two different Ca2+ pumps have…”
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N,N,N′,N′‐tetrakis(2‐pyridylmethyl)ethylenediamine induces apoptosis through the activation of caspases‐3 and ‐8 in human platelets. A role for endoplasmic reticulum stress by LÓPEZ, J. J., REDONDO, P.C., SALIDO, G. M., PARIENTE, J. A., ROSADO, J. A.

“…Background: Apoptosis or programmed cell death involves a number of biochemical events, including the activation of caspases, which lead to specific cell…”
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Immunophilins are involved in the altered platelet aggregation observed in patients with type 2 diabetes mellitus by López, E, Berna-Erro, A, Hernández-Cruz, J M, Salido, G M, Redondo, P C, Rosado, J A

“…Platelet hyperaggregability might contribute to vascular complications associated with type 2 diabetes mellitus (DM2).Experimental evidence supports a direct…”
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