Obesity-related gene ADRB2, ADRB3 and GHRL polymorphisms and the response to a weight loss diet intervention in adult women

The individual response to diet may be influenced by gene polymorphisms. This study hypothesized that ADRB2 (Gln27Glu, rs1042714 and Arg16Gly, rs1042713), ADRB3 (Trp64Arg, rs4994) and GHRL (Leu72Met, rs696217) polymorphisms moderate weight loss. The study was a seven weeks dietary weight loss interv...

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Bibliographic Details
Published in:	Genetics and molecular biology Vol. 37; no. 1; pp. 15 - 22
Main Authors:	Saliba, Louise F, Reis, Rodrigo S, Brownson, Ross C, Hino, Adriano A, Tureck, Luciane V, Valko, Cheryl, de Souza, Ricardo L R, Furtado-Alle, Lupe
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Genética 01-01-2014
Subjects:	adrenergic receptor polymorphism BIOCHEMISTRY & MOLECULAR BIOLOGY GENETICS & HEREDITY ghrelin polymorphism Human and Medical Genetics nutrigenetics obesity weight loss weight loss ghrelin polymorphism nutrigenetics adrenergic receptor polymorphism obesity
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Summary:	The individual response to diet may be influenced by gene polymorphisms. This study hypothesized that ADRB2 (Gln27Glu, rs1042714 and Arg16Gly, rs1042713), ADRB3 (Trp64Arg, rs4994) and GHRL (Leu72Met, rs696217) polymorphisms moderate weight loss. The study was a seven weeks dietary weight loss intervention with Brazilian adult obese women (n = 109). The body mass index (BMI) was calculated and polymorphisms in these genes were assessed by real-time PCR assays. Two-way repeated-measures ANOVA (2 × 2) were used to analyze the intervention effect between polymorphisms and BMI over the period and after stratification for age and socioeconomic status (SES). The weight loss intervention resulted in decreased BMI over the seven-week period (p < 0.001), for high and low SES (p < 0.05) and mainly for participants with 30-49 y. The intervention did not result in a statistically significant difference in weight loss between polymorphism carriers and non-carriers, and although, the ADRB2, ADRB3 and GHRL polymorphisms did not moderate weight loss, the Gln27Glu polymorphism carriers showed a lower BMI compared to non-carriers in the low SES (p = 0.018) and the 30-39 y (p = 0.036) groups, suggesting a role for this polymorphism related to BMI control.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1415-4757 1678-4685 1415-4757 1678-4685
DOI:	10.1590/S1415-47572014000100005