Antifungal activity of volatile constituents of Eugenia dysenterica leaf oil

The essential oil from the hydrodistillation of Eugenia dysenterica leaves consisted mainly of β-caryophyllene and α-humulene as the major sesquiterpene, while limonene and α-thujene were the major monoterpene hydrocarbons. The main oxygenated mono and sesquiterpene constituents were α-terpineol and...

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Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 72; no. 1; pp. 111 - 117
Main Authors:	Costa, Théo R., Fernandes, Orionalda F.L., Santos, Suzana C., Oliveira, Cecı́lia M.A., Lião, Luciano M., Ferri, Pedro H., Paula, José R., Ferreira, Heleno D., Sales, Beatriz H.N., Silva, Maria do Rosário R.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 01-09-2000 Elsevier
Subjects:	Antifungal activity Antifungal Agents - pharmacology Biological and medical sciences Brazil Candida albicans Candidiasis, Oral - microbiology Chromatography, Gas Cryptococcus neoformans Essential oil Eugenia dysenterica Fungi - drug effects General pharmacology HIV Infections - complications HIV Infections - microbiology Immunocompromised patients Medical sciences Meningitis, Cryptococcal - microbiology Microbial Sensitivity Tests Oils, Volatile - chemistry Oils, Volatile - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Plant Oils - chemistry Plant Oils - pharmacology Plants, Medicinal - chemistry Brazil Candida albicans Antifungal activity Eugenia dysenterica Essential oil Cryptococcus neoformans Immunocompromised patients Eugenia Medicinal plant Fungi Antifungal agent Dicotyledones Sesquiterpenes Angiospermae Myrtaceae Fungi Imperfecti Clinical isolate Thallophyta Volatile compound Human Immunopathology Pharmacognosy AIDS Plant leaf Immune deficiency In vitro Biological activity Infection Viral disease Plant origin Monoterpene Spermatophyta
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Summary:	The essential oil from the hydrodistillation of Eugenia dysenterica leaves consisted mainly of β-caryophyllene and α-humulene as the major sesquiterpene, while limonene and α-thujene were the major monoterpene hydrocarbons. The main oxygenated mono and sesquiterpene constituents were α-terpineol and β-caryophyllene oxide, respectively. The oil was investigated against eight strains of Candida albicans, 35 strains of Cryptococcus neoformans var. neoformans, and two C. neoformans var. gattii isolated from HIV-infected individuals with candidosis or cryptococcal meningitis using the agar dilution method. Based on the minimal inhibitory concentration (MIC) values, the most significant results were obtained against Cryptococcus strains. It was observed that 22 strains were inhibited at a concentration of 250 μg/ml, whereas four exhibited potent inhibition with MIC values below 125 μg/ml against 10 6 UFC/ml organisms. We found MICs≥3.12 μg/ml for 91.6, 50 and 30% of all Cryptococcus strains in relation of amphotericin B, fluconazole and itraconazole, respectively.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0378-8741 1872-7573
DOI:	10.1016/S0378-8741(00)00214-2