Search Results - "Salerno, Nadia"
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Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age
Published in Diabetes (New York, N.Y.) (01-05-2022)“…Diabetes mellitus (DM) affects the biology of multipotent cardiac stem/progenitor cells (CSCs) and adult myocardial regeneration. We assessed the hypothesis…”
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From Spheroids to Organoids: The Next Generation of Model Systems of Human Cardiac Regeneration in a Dish
Published in International journal of molecular sciences (07-12-2021)“…Organoids are tiny, self-organized, three-dimensional tissue cultures that are derived from the differentiation of stem cells. The growing interest in the use…”
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Timing of Complete Revascularization in Patients with STEMI and Multivessel Disease: A Systematic Review and Meta-Analysis
Published in Reviews in cardiovascular medicine (01-02-2023)“…About half of patients with ST-segment Elevation Myocardial Infarction (STEMI) have multivessel coronary artery disease (MVD). Our aim was to provide a…”
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Streptozotocin-Induced Type 1 and 2 Diabetes Mellitus Mouse Models Show Different Functional, Cellular and Molecular Patterns of Diabetic Cardiomyopathy
Published in International journal of molecular sciences (06-01-2023)“…The main cause of morbidity and mortality in diabetes mellitus (DM) is cardiovascular complications. Diabetic cardiomyopathy (DCM) remains incompletely…”
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Use of Impella device in cardiogenic shock and its clinical outcomes: A systematic review and meta-analysis
Published in International journal of cardiology. Heart & vasculature (01-06-2022)“…•Higher mechanical circulatory support (MCS), e.g. with Impella 5.0 and CP, reduces mortality in cardiogenic shock (CS).•Adequate device size and support is…”
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Polarizing Macrophage Functional Phenotype to Foster Cardiac Regeneration
Published in International journal of molecular sciences (28-06-2023)“…There is an increasing interest in understanding the connection between the immune and cardiovascular systems, which are highly integrated and communicate…”
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Underlying mechanisms and cardioprotective effects of SGLT2i and GLP-1Ra: insights from cardiovascular magnetic resonance
Published in Cardiovascular diabetology (11-03-2024)“…Originally designed as anti-hyperglycemic drugs, Glucagon-Like Peptide-1 receptor agonists (GLP-1Ra) and Sodium-glucose cotransporter-2 inhibitors (SGLT2i)…”
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Rationale for Early Administration of PCSK9 Inhibitors in Acute Coronary Syndrome
Published in Reviews in cardiovascular medicine (01-10-2024)“…Acute coronary syndromes (ACSs) represent a significant global health challenge arising from atherosclerotic cardiovascular disease (ASCVD), with elevated…”
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Physical Exercise and Cardiac Repair: The Potential Role of Nitric Oxide in Boosting Stem Cell Regenerative Biology
Published in Antioxidants (23-06-2021)“…Over the years strong evidence has been accumulated showing that aerobic physical exercise exerts beneficial effects on the prevention and reduction of…”
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Lyotropic Liquid Crystals: A Biocompatible and Safe Material for Local Cardiac Application
Published in Pharmaceutics (20-02-2022)“…The regeneration of cardiac tissue is a multidisciplinary research field aiming to improve the health condition of the post-heart attack patient. Indeed,…”
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Standard Versus Ultrasound-Guided Cannulation of the Femoral Artery in Patients Undergoing Invasive Procedures: A Meta-Analysis of Randomized Controlled Trials
Published in Journal of clinical medicine (03-03-2020)“…It is unclear whether or not ultrasound-guided cannulation (UGC) of the femoral artery is superior to the standard approach (SA) in reducing vascular…”
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Myocardial regeneration protocols towards the routine clinical scenario: An unseemly path from bench to bedside
Published in EClinicalMedicine (01-08-2022)“…Heart failure secondary to cardiomyocyte loss and/or dysfunction is the number one killer worldwide. The field of myocardial regeneration with its far-reaching…”
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Unraveling and Targeting Myocardial Regeneration Deficit in Diabetes
Published in Antioxidants (22-01-2022)“…Cardiomyopathy is a common complication in diabetic patients. Ventricular dysfunction without coronary atherosclerosis and hypertension is driven by…”
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Adult Multipotent Cardiac Progenitor-Derived Spheroids: A Reproducible Model of In Vitro Cardiomyocyte Commitment and Specification
Published in Cells (Basel, Switzerland) (01-07-2023)“…Three-dimensional cell culture systems hold great promise for bridging the gap between in vitro cell-based model systems and small animal models to study…”
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COVID-19 and STEMI: The role of telecardiology in the management of STEMI diagnosis during COVID 19 pandemic
Published in International journal of cardiology. Heart & vasculature (01-02-2021)“…Telecardiology has the advantage of reducing patient's access time to the hemodynamics units. Data from literature show a reduction in ST-elevation myocardial…”
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A Mouse Model of Dilated Cardiomyopathy Produced by Isoproterenol Acute Exposure Followed by 5-Fluorouracil Administration
Published in Journal of cardiovascular development and disease (23-05-2023)“…Appropriate dilated cardiomyopathy (DCM) animal models are highly desirable considering the pathophysiological and clinical heterogeneity of DCM. Genetically…”
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SETD7 methyltransferase is a key druggable target for effective cardioprotection from myocardial ischaemic injury
Published in Cardiovascular research (18-01-2023)Get full text
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Senescent cells enhance ischemic aging in the female heart
Published in Aging (Albany, NY.) (23-03-2023)Get full text
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Cardiac stem cell therapy towards the clinic: The way forward re-starts from within
Published in International journal of cardiology (15-12-2021)Get full text
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Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice
Published in Mechanisms of ageing and development (01-12-2022)“…Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific differences exist and the mechanism(s) by which this sex-by-age…”
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