Search Results - "Salem, Ola I.A."

Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production by Youssif, Bahaa G.M., Abdelrahman, Mostafa H., Abdelazeem, Ahmed H., abdelgawad, Mohamed A., Ibrahim, Hussein M., Salem, Ola I.A., Mohamed, Mamdouh F.A., Treambleau, Laurent, Bukhari, Syed Nasir Abbas

“…A series of novel compounds carrying pyrazino[1,2-a]indol-1(2H)-one scaffold (5a-g) and their reaction intermediates, indole-2-carboxamides, (3a-g) were…”
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Design, synthesis and antiproliferative evaluation of lipidated 1,3-diaryl propenones and their cyclized pyrimidine derivatives as tubulin polymerization inhibitors by Ali, Fatma Elzahraa, Salem, Ola I.A., El-Mokhtar, Mohamed A., Aboraia, Ahmed S., Abdel-Moty, Samia G., Abdel-Aal, Abu-Baker M.

“…[Display omitted] •Sixteen new chalcones and their cyclized pyrimidine derivatives were synthesized.•The lipidated 4,6-diaryl pyrimidine-2-amine 19 exhibited…”
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Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes by Maghraby, Mohammed T.-E., Abou-Ghadir, Ola M.F., Abdel-Moty, Samia G., Ali, Asmaa Y., Salem, Ola I.A.

“…[Display omitted] •Design and synthesis of novel dual COX-2 and 15-LOX benzimidazole-thiazole hybrids.•Potent COX-2 inhibition with high selectivity comparable…”
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Design, synthesis, and antiproliferative properties of new 1,2,3-triazole-carboximidamide derivatives as dual EGFR/VEGFR-2 inhibitors by Mahmoud, Mohamed A., Mohammed, Anber F., Salem, Ola I.A., Rabea, Safwat M., Youssif, Bahaa G.M.

“…•A series of 1,2,3-triazole-carboximidamide derivatives was designed and synthesised.•The new compounds were evaluated as antiproliferative agent targeting…”
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Novel fluoroquinolone hybrids as dual DNA gyrase and urease inhibitors with potential antibacterial activity: Design, synthesis, and biological evaluation by Abdel-Aziz, Salah A., Cirnski, Katarina, Herrmann, Jennifer, Abdel-Aal, Mohamed A.A., Youssif, Bahaa G.M., Salem, Ola I.A.

“…•New fluoroquinolone hybrids (4a−h and 5a−h) have been synthesized.•We assessed their purity and confirmed the elucidation of their structures.•Their…”
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New 1,3,4‐oxadiazoles linked with the 1,2,3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase by Mahmoud, Mohamed A., Mohammed, Anber F., Salem, Ola I. A., Gomaa, Hesham A. M., Youssif, Bahaa G. M.

“…A series of 1,3,4‐oxadiazole‐1,2,3‐triazole hybrids bearing different pharmacophoric moieties has been designed and synthesized. Their antiproliferative…”
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Novel 1,2,4-triazole derivatives as apoptotic inducers targeting p53: Synthesis and antiproliferative activity by Gomaa, Hesham A.M., El-Sherief, Hany A.M., Hussein, Shaimaa, Gouda, Ahmed M., Salem, Ola I.A., Alharbi, Khalid Saad, Hayallah, Alaa M., Youssif, Bahaa G.M.

“…[Display omitted] •Novel thiazolo[3,2-b][1,2,4] triazoles 3a-n has been synthesized and evaluated in vitro as antiproliferative agents.•The most potent…”
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Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors by Mahmoud, Mohamed A, Mohammed, Anber F, Salem, Ola I A, Almutairi, Tahani Mazyad, Bräse, Stefan, Youssif, Bahaa G M

“…A novel series of 1,2,3-triazole/1,2,4-oxadiazole hybrids ( - ) was developed as dual inhibitors of EGFR/VEGFR-2. Compounds - were evaluated as…”
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New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity by Maghraby, Mohamed T-E, Mazyad Almutairi, Tahani, Bräse, Stefan, Salem, Ola I. A, Youssif, Bahaa G. M, Sheha, Mahmoud M

“…A novel series of 1,2,3-triazole/1,2,4-triazole hybrids 5a, 5b, and 6a–i was designed and synthesized as antiproliferative agents targeting aromatase enzymes…”
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New pyrimidine/thiazole hybrids endowed with analgesic, anti‐inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX‐2/sEH dual inhibition by Abdel‐Aziz, Salah A., Taher, Ehab S., Lan, Ping, El‐Koussi, Nawal A., Salem, Ola I. A., Gomaa, Hesham A. M., Youssif, Bahaa G. M.

“…Some cyclooxygenase (COX)‐2 selective medications were withdrawn from the market just a few years after their production due to cardiovascular side effects. In…”
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Novel N-substituted 5-aminosalicylamides as dual inhibitors of cyclooxygenase and 5-lipoxygenase enzymes: Synthesis, biological evaluation and docking study by El-Nagar, Mohamed K.S., Abdu-Allah, Hajjaj H.M., Salem, Ola I.A., Kafafy, Abdel-Hamid N., Farghaly, Hanan S.M.

“…[Display omitted] •Synthesis of novel 5-aminosalicylamide derivatives.•In vivo anti-inflammatory activity was evaluated.•Compound 34 &35 showed the best COX-2…”
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Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors by Al-Wahaibi, Lamya H., Gouda, Ahmed M., Abou-Ghadir, Ola F., Salem, Ola I.A., Ali, Asmaa T., Farghaly, Hatem S., Abdelrahman, Mostafa H., Trembleau, Laurent, Abdu-Allah, Hajjaj H.M., Youssif, Bahaa G.M.

“…[Display omitted] •A series of novel pyrazino-indole-1,4-dione derivatives as dual EGFR/ BRAFV600E inhibitors has been designed and synthesized.•Compounds 22,…”
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Synthesis and antimicrobial evaluation of some new thiazoline and thiazolidinone derivatives incorporating [1,2,4]triazolo[1,5-a]benzimidazole by Mahmoud, A, Salem, Ola, Abdel Moty, Samia, Abdel Alim, A

“…Two new series of 3-[2-(3,4-disubstituted-2,3-dihydrothiazol-2-ylidene)hydrazonopropylidenyl]-2-(methylthio)-3H-[1,2,4]triazolo[1,5-a]benzimidazole (6-29) and…”
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Novel 5α-Reductase Inhibitors:  Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids by Salem, Ola I. A, Frotscher, Martin, Scherer, Christiane, Neugebauer, Alexander, Biemel, Klaus, Streiber, Martina, Maas, Ruth, Hartmann, Rolf W

“…Novel substituted benzoyl benzoic acids and phenylacetic acids 1 − 14 have been synthesized and evaluated for inhibition of rat and human steroid 5α-reductase…”
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Prooxidant and antioxidant action of 4-(4-phenoxybenzoyl)benzoic acid derivatives by Aboul-Enein, Hassan Y., Kladna, Alexandra, Kruk, Irena, Lichszteld, Krzysztof, Marchlewicz, Mariola, Michalska, Teresa, Salem, Ola I. A., Hartmann, Rolf W.

“…4‐(4‐Phenoxybenzoyl)benzoic acid derivatives (PBADs) were found to inhibit rat and human α‐reductase isozymes 1 and 2 in vitro. Chemiluminescence (CL),…”
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Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase by Baston, Eckhard, Salem, Ola I. A., Hartmann, Rolf W.

“…In search of novel nonsteroidal mimics of steroidal inhibitors of 5α reductase, 4‐(2‐phenylethyl)cyclohex‐1‐ene carboxylic acids 1—5 were synthesized with…”
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Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2 by Salem, Ola I. A., Schulz, Tobias, Hartmann, Rolf W.

“…The synthesis and biological evaluation of 4‐(4‐(alkyl‐ and phenylaminocarbonyl)‐benzoyl)benzoic acids (4a—4d) as non‐steroidal inhibitors of steroid…”
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