Search Results - "Saleh, Aljona"

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage by Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia

“…The development of non-genotoxic therapies that activate wild-type p53 in tumors is of great interest since the discovery of p53 as a tumor suppressor. Here we…”
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Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage by Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Fernández, Andrés Pastor, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia

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Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage by Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia

“…The original PDF version of this Article listed the authors as “Marcus J.G.W. Ladds,” where it should have read “Marcus J. G. W. Ladds, Ingeborg M. M. van…”
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Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS by Wegler, Christine, Saleh, Aljona, Lindqvist, Annika, Nordeng, Hedvig, Smeraglia, John, Baranczewski, Pawel

“…•Rapid, sensitive methods for high-throughput analysis of drugs in human breast milk.•Simultaneous milk quantification of cetirizine, venlafaxine,…”
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool by Gad, Helge, Koolmeister, Tobias, Jemth, Ann-Sofie, Eshtad, Saeed, Jacques, Sylvain A., Ström, Cecilia E., Svensson, Linda M., Schultz, Niklas, Lundbäck, Thomas, Einarsdottir, Berglind Osk, Saleh, Aljona, Göktürk, Camilla, Baranczewski, Pawel, Svensson, Richard, Berntsson, Ronnie P.-A., Gustafsson, Robert, Strömberg, Kia, Sanjiv, Kumar, Jacques-Cordonnier, Marie-Caroline, Desroses, Matthieu, Gustavsson, Anna-Lena, Olofsson, Roger, Johansson, Fredrik, Homan, Evert J., Loseva, Olga, Bräutigam, Lars, Johansson, Lars, Höglund, Andreas, Hagenkort, Anna, Pham, Therese, Altun, Mikael, Gaugaz, Fabienne Z., Vikingsson, Svante, Evers, Bastiaan, Henriksson, Martin, Vallin, Karl S. A., Wallner, Olov A., Hammarström, Lars G. J., Wiita, Elisee, Almlöf, Ingrid, Kalderén, Christina, Axelsson, Hanna, Djureinovic, Tatjana, Puigvert, Jordi Carreras, Häggblad, Maria, Jeppsson, Fredrik, Martens, Ulf, Lundin, Cecilia, Lundgren, Bo, Granelli, Ingrid, Jensen, Annika Jenmalm, Artursson, Per, Nilsson, Jonas A., Stenmark, Pål, Scobie, Martin, Berglund, Ulrika Warpman, Helleday, Thomas

“…Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes…”
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Validation and development of MTH1 inhibitors for treatment of cancer by Warpman Berglund, U., Sanjiv, K., Gad, H., Kalderén, C., Koolmeister, T., Pham, T., Gokturk, C., Jafari, R., Maddalo, G., Seashore-Ludlow, B., Chernobrovkin, A., Manoilov, A., Pateras, I.S., Rasti, A., Jemth, A.-S., Almlöf, I., Loseva, O., Visnes, T., Einarsdottir, B.O., Gaugaz, F.Z., Saleh, A., Platzack, B., Wallner, O.A., Vallin, K.S.A., Henriksson, M., Wakchaure, P., Borhade, S., Herr, P., Kallberg, Y., Baranczewski, P., Homan, E.J., Wiita, E., Nagpal, V., Meijer, T., Schipper, N., Rudd, S.G., Bräutigam, L., Lindqvist, A., Filppula, A., Lee, T.-C., Artursson, P., Nilsson, J.A., Gorgoulis, V.G., Lehtiö, J., Zubarev, R.A., Scobie, M., Helleday, T.

“…Different MTH1 inhibitors have different ability to kill cancer cells. Here we demonstrate that the lack of efficiency of some MTH1 inhibitors is explained by…”
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Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability by Popova, Gergana, Ladds, Marcus J. G. W, Johansson, Lars, Saleh, Aljona, Larsson, Johanna, Sandberg, Lars, Sahlberg, Sara Häggblad, Qian, Weixing, Gullberg, Hjalmar, Garg, Neeraj, Gustavsson, Anna-Lena, Haraldsson, Martin, Lane, David, Yngve, Ulrika, Lain, Sonia

“…Human dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo pyrimidine synthesis pathway, is a target for the treatment of rheumatoid arthritis and…”
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Evaluation of a direct high-capacity target screening approach for urine drug testing using liquid chromatography–time-of-flight mass spectrometry by Saleh, Aljona, Stephanson, Niclas Nikolai, Granelli, Ingrid, Villén, Tomas, Beck, Olof

“…► A multi target analytical approach for clinical drugs of abuse screening was explored. ► The analysis time was short. ► The selectivity was based on high…”
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An Adaptable Antibody‐Based Platform for Flexible Synthetic Peptide Delivery Built on Agonistic CD40 Antibodies (Adv. Therap. 7/2022) by Eltahir, Mohamed, Laurén, Ida, Lord, Martin, Chourlia, Aikaterini, Dahllund, Leif, Olsson, Anders, Saleh, Aljona, Ytterberg, A. Jimmy, Lindqvist, Annika, Andersson, Oskar, Persson, Helena, Mangsbo, Sara M.

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Abstract 2890: The development of an Adaptable Drug Affinity Conjugate (ADAC) targeting CD40 for a flexible therapeutic peptide cargo delivery to dendritic cells by Laurén, Ida, Eltahir, Mohamed, Mebrahtu, Aman, Veerman, Rosanne, Astorga, Juan, Saleh, Aljona, Ytterberg, Jimmy, Lindqvist, Annika, Dahllund, Leif, Olsson, Anders, Andersson, Oskar, Rockberg, Johan, Persson, Helena, Mangsbo, Sara

“…Abstract CD40 agonistic antibodies targeting antigen-presenting cells rely on simultaneous antigen presentation for optimal efficacy, as the co-stimulatory…”
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Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma by Saleh, Aljona, Gökturk, Camilla, Warpman-Berglund, Ulrika, Helleday, Thomas, Granelli, Ingrid

“…•A bioanalytical method was developed for quantification of MTH1 inhibitors, TH588 and TH287.•Method was validated for TH588 and TH287 and their metabolite in…”
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An Adaptable Antibody‐Based Platform for Flexible Synthetic Peptide Delivery Built on Agonistic CD40 Antibodies by Eltahir, Mohamed, Laurén, Ida, Lord, Martin, Chourlia, Aikaterini, Dahllund, Leif, Olsson, Anders, Saleh, Aljona, Ytterberg, A. Jimmy, Lindqvist, Annika, Andersson, Oskar, Persson, Helena, Mangsbo, Sara M.

“…The agonistic potentials of therapeutic anti‐CD40 antibodies have been profiled in relation to antibody isotype and epitope specificity. Still, clinical impact…”
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A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage by Ladds, MJGW, van, Leeuwen IMM, Drummond, CJ, Chu, S, Healy, AR, Popova, G, Fernandez, AP, Mollick, T, Darekar, S, Sedimbi, SK

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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool (vol 508, pg 215, 2014) by Gad, H, Koolmeister, T, Jemth, A-S, Eshtad, S, Jacques, SA, Strom, CE, Svensson, LM, Schultz, N, Lundback, T, Einarsdottir, BO

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Digestion of Enolase and Carbonic Anhydrase as Model Proteins for Therapeutic Proteins in Blood Plasma with Immobilized Thermolysin and Quantification of Some of the Peptides by LC/LC–MS/MS by Saleh, Aljona, Bruno, Oscar, Granelli, Ingrid, Edlund, Per-Olof

“…There is a need for fast method development in the early drug discovery phase of therapeutic proteins. Thermolysin has not been used for quantification of…”
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Correction: Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool by Gad, Helge, Koolmeister, Tobias, Jemth, Ann-Sofie, Eshtad, Saeed, Jacques, Sylvain A., Ström, Cecilia E., Svensson, Linda M., Schultz, Niklas, Lundbäck, Thomas, Einarsdottir, Berglind Osk, Saleh, Aljona, Göktürk, Camilla, Baranczewski, Pawel, Svensson, Richard, Berntsson, Ronnie P.-A., Gustafsson, Robert, Strömberg, Kia, Sanjiv, Kumar, Jacques-Cordonnier, Marie-Caroline, Desroses, Matthieu, Gustavsson, Anna-Lena, Olofsson, Roger, Johansson, Fredrik, Homan, Evert J., Loseva, Olga, Bräutigam, Lars, Johansson, Lars, Höglund, Andreas, Hagenkort, Anna, Pham, Therese, Altun, Mikael, Gaugaz, Fabienne Z., Vikingsson, Svante, Evers, Bastiaan, Henriksson, Martin, Vallin, Karl S. A., Wallner, Olov A., Hammarström, Lars G. J., Wiita, Elisee, Almlöf, Ingrid, Kalderén, Christina, Axelsson, Hanna, Djureinovic, Tatjana, Carreras Puigvert, Jordi, Häggblad, Maria, Jeppsson, Fredrik, Martens, Ulf, Lundin, Cecilia, Lundgren, Bo, Granelli, Ingrid, Jenmalm Jensen, Annika, Artursson, Per, Nilsson, Jonas A., Stenmark, Pål, Scobie, Martin

“…Nature 508, 215–221 (2014); doi:10.1038/nature13181 In this Article, the structure of compound TH650 (4) in Fig. 4a was drawn incorrectly; the correct…”
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Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool by Gad, Helge, Koolmeister, Tobias, Jemth, Ann-Sofie, Eshtad, Saeed, Jacques, Sylvain A, Ström, Cecilia E, Svensson, Linda M, Schultz, Niklas, Lundbäck, Thomas, Einarsdottir, Berglind Osk, Saleh, Aljona, Göktürk, Camilla, Baranczewski, Pawel, Svensson, Richard, Berntsson, Ronnie P-A, Gustafsson, Robert, Strömberg, Kia, Sanjiv, Kumar, Jacques-Cordonnier, Marie-Caroline, Desroses, Matthieu, Gustavsson, Anna-Lena, Olofsson, Roger, Johansson, Fredrik, Homan, Evert J, Loseva, Olga, Bräutigam, Lars, Johansson, Lars, Höglund, Andreas, Hagenkort, Anna, Pham, Therese, Altun, Mikael, Gaugaz, Fabienne Z, Vikingsson, Svante, Evers, Bastiaan, Henriksson, Martin, Vallin, Karl S A, Wallner, Olov A, Hammarström, Lars G J, Wiita, Elisee, Almlöf, Ingrid, Kalderén, Christina, Axelsson, Hanna, Djureinovic, Tatjana, Carreras Puigvert, Jordi, Häggblad, Maria, Jeppsson, Fredrik, Martens, Ulf, Lundin, Cecilia, Lundgren, Bo, Granelli, Ingrid, Jenmalm Jensen, Annika, Artursson, Per, Nilsson, Jonas A, Stenmark, Pål, Scobie, Martin

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Bioanalytical Method for Quantification of Thioredoxins in Bacillus anthracis by Digestion with Immobilized Pepsin and LC–MS/MS and On-line LC/LC–MS/MS by Saleh, Aljona, Edlund, Per-Olof, Gustafsson, Tomas N., Sahlin, Margareta, Sjöberg, Britt-Marie, Granelli, Ingrid

“…We describe a method for the quantification of proteins in a biological matrix through digestion with pepsin. Pepsin is a gastric protease that efficiently…”
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