Zinc and vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia

A previous study showed that combination of zinc and vitamin A reduced sputum conversion time in pulmonary tuberculosis (TB) patients. We studied the efficacy of which single micronutrient contributed more to the sputum conversion time. In a double-blind randomized community trial, newly sputum smea...

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Bibliographic Details
Published in:	Nutrition journal Vol. 9; no. 1; p. 41
Main Authors:	Pakasi, Trevino A, Karyadi, Elvina, Suratih, Ni Made Desy, Salean, Michael, Darmawidjaja, Nining, Bor, Hans, van der Velden, Koos, Dolmans, Wil M V, van der Meer, Jos W M
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 28-09-2010 BioMed Central BMC
Subjects:	Adolescent Adult Antitubercular Agents - therapeutic use Body mass index Care and treatment Colleges & universities Data collection Diagnosis Double-Blind Method Drug resistance Female Health aspects Hospitals Humans Immune System - drug effects Indonesia Male Malnutrition - complications Malnutrition - drug therapy Medicine Middle Aged Mycobacterium Mycobacterium tuberculosis - isolation & purification Nutrition Nutritional Status Plasma Pulmonary tuberculosis Sputum - microbiology Treatment Outcome Tuberculosis Tuberculosis, Pulmonary - complications Tuberculosis, Pulmonary - drug therapy Vitamin A Vitamin A - therapeutic use Vitamins - therapeutic use Zinc Zinc - therapeutic use Zinc in the body Indonesia
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Summary:	A previous study showed that combination of zinc and vitamin A reduced sputum conversion time in pulmonary tuberculosis (TB) patients. We studied the efficacy of which single micronutrient contributed more to the sputum conversion time. In a double-blind randomized community trial, newly sputum smear positive pulmonary TB patients were assigned randomly to receive zinc, vitamin A, zinc + vitamin A or placebo on top of TB treatment. Patients were asked to deliver their sputum on weekly basis to measure positivity of the bacteria. Nutritional status, chest x-ray, hemoglobin, C-reactive protein (CRP), retinol and zinc level were examined prior to, after 2 and 6 months of treatment. Initially, 300 patients were enrolled, and 255 finished the treatment. Most patients were severely malnourished (mean BMI 16.5 ± 2.2 Kg/m2). Patients in the zinc + vitamin A group showed earlier sputum conversion time (mean 1.9 weeks) compared with that in the other groups; however the difference was not significant. Also, no benefit could be demonstrated of any of the used supplementations on clinical, nutritional, chest x-ray, or laboratory findings. This study among severely malnourished TB patients, did not confirm that single or combined supplementation of zinc and vitamin A significantly reduced sputum conversion time or had other significant benefit.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 ObjectType-Feature-1
ISSN:	1475-2891 1475-2891
DOI:	10.1186/1475-2891-9-41