Search Results - "Sale, Julian E"

Replication of G Quadruplex DNA by Lerner, Leticia Koch, Sale, Julian E

“…A cursory look at any textbook image of DNA replication might suggest that the complex machine that is the replisome runs smoothly along the chromosomal DNA…”
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Competition, collaboration and coordination--determining how cells bypass DNA damage by Sale, Julian E

“…Cells must overcome replication blocks that might otherwise lead to genomic instability or cell death. Classical genetic experiments have identified a series…”
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DNA polymerase stalling at structured DNA constrains the expansion of short tandem repeats by Murat, Pierre, Guilbaud, Guillaume, Sale, Julian E

“…Short tandem repeats (STRs) contribute significantly to de novo mutagenesis, driving phenotypic diversity and genetic disease. Although highly diverse, their…”
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PRIMPOL ensures robust handoff between on-the-fly and post-replicative DNA lesion bypass by Mellor, Christopher, Nassar, Joelle, Šviković, Saša, Sale, Julian E

“…Abstract The primase/polymerase PRIMPOL restarts DNA synthesis when replication is arrested by template impediments. However, we do not have a comprehensive…”
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Determination of human DNA replication origin position and efficiency reveals principles of initiation zone organisation by Guilbaud, Guillaume, Murat, Pierre, Wilkes, Helen S, Lerner, Leticia Koch, Sale, Julian E, Krude, Torsten

“…Replication of the human genome initiates within broad zones of ∼150 kb. The extent to which firing of individual DNA replication origins within initiation…”
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PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells by Schiavone, Davide, Jozwiakowski, Stanislaw K., Romanello, Marina, Guilbaud, Guillaume, Guilliam, Thomas A., Bailey, Laura J., Sale, Julian E., Doherty, Aidan J.

“…G quadruplexes (G4s) can present potent blocks to DNA replication. Accurate and timely replication of G4s in vertebrates requires multiple specialized DNA…”
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Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds by Zimmer, Jutta, Tacconi, Eliana M.C., Folio, Cecilia, Badie, Sophie, Porru, Manuela, Klare, Kerstin, Tumiati, Manuela, Markkanen, Enni, Halder, Swagata, Ryan, Anderson, Jackson, Stephen P., Ramadan, Kristijan, Kuznetsov, Sergey G., Biroccio, Annamaria, Sale, Julian E., Tarsounas, Madalena

“…G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and…”
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REV7/MAD2L2: the multitasking maestro emerges as a barrier to recombination by Sale, Julian E

“…REV7/MAD2L2 plays important roles in translesion DNA synthesis and mitotic control. Two new papers extend its gamut by revealing its unexpected participation…”
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Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset by Listovsky, Tamar, Sale, Julian E

“…The switch from activation of the anaphase-promoting complex/cyclosome (APC/C) by CDC20 to CDH1 during anaphase is crucial for accurate mitosis. APC/C(CDC20)…”
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Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression by Papadopoulou, Charikleia, Guilbaud, Guillaume, Schiavone, Davide, Sale, Julian E.

“…Nucleotide pool imbalance has been proposed to drive genetic instability in cancer. Here, we show that slowing replication forks by depleting nucleotide pools…”
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Histone H3.3 Is Required to Maintain Replication Fork Progression after UV Damage by Frey, Alexander, Listovsky, Tamar, Guilbaud, Guillaume, Sarkies, Peter, Sale, Julian E.

“…Unlike histone H3, which is present only in S phase, the variant histone H3.3 is expressed throughout the cell cycle [1] and is incorporated into chromatin…”
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PCNA Ubiquitination and REV1 Define Temporally Distinct Mechanisms for Controlling Translesion Synthesis in the Avian Cell Line DT40 by Edmunds, Charlotte E., Simpson, Laura J., Sale, Julian E.

“…Translesion synthesis (TLS) is a potentially mutagenic method of bypassing DNA damage encountered during replication that requires the recruitment of…”
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CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs by Mohiuddin, Mohiuddin, Rahman, Md Maminur, Sale, Julian E, Pearson, Christopher E

“…Abstract Chain-terminating nucleoside analogs (CTNAs), which cannot be extended by DNA polymerases, are widely used as antivirals or anti-cancer agents, and…”
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In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding by Bate, Neil, Savva, Christos G, Moody, Peter C E, Brown, Edward A, Evans, Sian E, Ball, Jonathan K, Schwabe, John W R, Sale, Julian E, Brindle, Nicholas P J

“…Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19 pandemic. Being able to predict mutations that could arise in SARS-CoV-2…”
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Deubiquitination of FANCD2 Is Required for DNA Crosslink Repair by Oestergaard, Vibe H., Langevin, Frederic, Kuiken, Hendrik J., Pace, Paul, Niedzwiedz, Wojciech, Simpson, Laura J., Ohzeki, Mioko, Takata, Minoru, Sale, Julian E., Patel, Ketan J.

“…Monoubiquitination of FANCD2 and PCNA promotes DNA repair. It causes chromatin accumulation of FANCD2 and facilitates PCNA's recruitment of translesion…”
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Unwinding to Recombine by Guilbaud, Guillaume, Sale, Julian E.

“…The MCM proteins are best known for their role in DNA replication, MCM2-7 forming the replicative helicase. Now, two reports in this issue of Molecular Cell,…”
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Propagation of histone marks and epigenetic memory during normal and interrupted DNA replication by Sarkies, Peter, Sale, Julian E.

“…Although all nucleated cells within a multicellular organism contain a complete copy of the genome, cell identity relies on the expression of a specific subset…”
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Focus and persistence: how Pol IV unblocks stalled DNA synthesis by Sale, Julian E.

“…The mechanisms by which translesion DNA polymerases mediate DNA repair are incompletely understood. A new study shows that Escherichia coli DNA polymerase IV…”
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Cells Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde by RIDPATH, John R, NAKAMURA, Ayumi, BISHOP, Douglas K, TAKATA, Minoru, TAKEDA, Shunichi, WATANABE, Masami, SWENBERG, James A, NAKAMURA, Jun, TANO, Keizo, LUKE, April M, SONODA, Eiichiro, ARAKAWA, Hiroshi, BUERSTEDDE, Jean-Marie, GILLESPIE, David A. F, SALE, Julian E, YAMAZOE, Mitsuyoshi

“…Formaldehyde is an aliphatic monoaldehyde and is a highly reactive environmental human carcinogen. Whereas humans are continuously exposed to exogenous…”
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A NuRD Complex from Xenopus laevis Eggs Is Essential for DNA Replication during Early Embryogenesis by Christov, Christo P., Dingwell, Kevin S., Skehel, Mark, Wilkes, Helen S., Sale, Julian E., Smith, James C., Krude, Torsten

“…DNA replication in the embryo of Xenopus laevis changes dramatically at the mid-blastula transition (MBT), with Y RNA-independent random initiation switching…”
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