Search Results - "Sale, J"

Systematic review on interventions to improve osteoporosis investigation and treatment in fragility fracture patients by Sale, J. E. M., Beaton, D., Posen, J., Elliot-Gibson, V., Bogoch, E.

“…This study aims to determine osteoporosis (OP) investigation and treatment within post-fracture initiatives conducted in fracture clinics and other orthopedic…”
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MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road by Caunt, Christopher J., Sale, Matthew J., Smith, Paul D., Cook, Simon J.

“…Key Points The RAS-regulated RAF–MEK–ERK signalling pathway transmits signals from growth factor receptors to the nucleus and other organelles to regulate cell…”
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Coordinator-based systems for secondary prevention in fragility fracture patients by Marsh, D., Åkesson, K., Beaton, D. E., Bogoch, E. R., Boonen, S., Brandi, M.-L., McLellan, A. R., Mitchell, P. J., Sale, J. E. M., Wahl, D. A.

“…The underlying causes of incident fractures—bone fragility and the tendency to fall—remain under-diagnosed and under-treated. This care gap in secondary…”
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Patients not taking a previously prescribed bone active medication now prescribed medication through Ontario FLS by Sale, J. E. M., Yang, A., Inrig, T., Gandhi, S., Elliot-Gibson, V., Sujic, R., Jain, R., Weldon, J., Linton, D., Bogoch, E.

“…Summary In an Ontario fracture liaison service (FLS), we compared medication prescription rates among patients not taking a previously prescribed bone active…”
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Patients 80 + have similar medication initiation rates to those aged 50–79 in Ontario FLS by Sale, J. E. M., Yang, A., Elliot-Gibson, V., Jain, R., Sujic, R., Linton, D., Weldon, J., Frankel, L., Bogoch, E.

“…Summary Among individuals presenting to an Ontario FLS, we compared bone active medication initiation rates of patients 80 years and older with those…”
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Period Prevalence and Perceived Side Effects of Hormonal Contraceptive Use and the Menstrual Cycle in Elite Athletes by Martin, Daniel, Sale, Craig, Cooper, Simon B, Elliott-Sale, Kirsty J

“…To identify the period prevalence of hormonal contraceptive (HC) use and characterize the perceived side effects associated with the menstrual cycle and HC…”
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Reduced energy availability: implications for bone health in physically active populations by Papageorgiou, Maria, Dolan, Eimear, Elliott-Sale, Kirsty J., Sale, Craig

“…Purpose The present review critically evaluates existing literature on the effects of short- and long-term low energy availability (EA) on bone metabolism and…”
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Long-term experiences of pain after a fragility fracture by Gheorghita, A., Webster, F., Thielke, S., Sale, J. E. M.

“…Summary Little is known about long-term pain after a fragility fracture. In this secondary analysis, we determined that pain continues to influence many…”
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Patients do not have a consistent understanding of high risk for future fracture: a qualitative study of patients from a post-fracture secondary prevention program by Sale, J. E. M., Gignac, M. A., Hawker, G., Beaton, D., Frankel, L., Bogoch, E., Elliot-Gibson, V.

“…Summary We examined fracture patients’ understanding of “high” fracture risk after they were screened through a post-fracture secondary prevention program and…”
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Educational booklet reinforces knowledge of osteoporosis and influences intentions to improve bone health in previously diagnosed and treated patients by Linton, D. N., Porteous, J., Eatson, H., Chepesiuk, R., Long, T., Inrig, T. M., Frankel, L., Jain, R., Sale, J. E. M.

“…Summary We examined individuals’ experiences using an educational booklet developed by the Ontario Osteoporosis Strategy. The booklet appeared to motivate…”
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Effects of reduced energy availability on bone metabolism in women and men by Papageorgiou, Maria, Elliott-Sale, Kirsty J., Parsons, Alan, Tang, Johnathan C.Y., Greeves, Julie P., Fraser, William D., Sale, Craig

“…The short-term effects of low energy availability (EA) on bone metabolism in physically active women and men are currently unknown. We evaluated the effects of…”
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SLFN11 informs on standard of care and novel treatments in a wide range of cancer models by Winkler, Claudia, Armenia, Joshua, Jones, Gemma N., Tobalina, Luis, Sale, Matthew J., Petreus, Tudor, Baird, Tarrion, Serra, Violeta, Wang, Anderson T., Lau, Alan, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Pierce, Andrew J., O’Connor, Mark J., Leo, Elisabetta

“…Background Schlafen 11 (SLFN11) has been linked with response to DNA-damaging agents (DDA) and PARP inhibitors. An in-depth understanding of several aspects of…”
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Evidence of patient beliefs, values, and preferences is not provided in osteoporosis clinical practice guidelines by Sale, J.E.M., Marwah, A., Naeem, F., Yu, W., Meadows, L.

“…Summary We examined how patient beliefs, values, and preferences (BVPs) were included and conceptualized in international osteoporosis guidelines. The majority…”
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Patient perceptions of provider barriers to post-fracture secondary prevention by Sale, J. E. M., Bogoch, E., Hawker, G., Gignac, M., Beaton, D., Jaglal, S., Frankel, L.

“…Summary We examined patients’ experiences regarding bone mineral density (BMD) testing and bone health treatment after being screened through Ontario’s…”
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Fragility fracture patients with a history of prior fractures more likely to present with multiple risk factors: findings from a province-wide fracture liaison service by Sujic, R., Yang, A., Ansari, H., Bogoch, E. R., Jain, R., Weldon, J., Elliot-Gibson, V., Sale, J. E. M.

“…Summary We examined the demographic characteristics and risk factors of FLS fragility fracture patients who had sustained prior fragility fracture(s) and found…”
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Five-year refracture rates of a province-wide fracture liaison service by Sujic, R., Beaton, D.E., Mamdani, M., Cadarette, S.M., Luo, J., Jaglal, S., Sale, J.E.M., Jain, R., Bogoch, E.

“…Summary We examined the 5-year refracture rate of 6543 patients and found an overall rate of 9.7%. Adjusted analysis showed that presenting with multiple…”
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Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors by Sale, Matthew J., Minihane, Emma, Monks, Noel R., Gilley, Rebecca, Richards, Frances M., Schifferli, Kevin P., Andersen, Courtney L., Davies, Emma J., Vicente, Mario Aladren, Ozono, Eiko, Markovets, Aleksandra, Dry, Jonathan R., Drew, Lisa, Flemington, Vikki, Proia, Theresa, Jodrell, Duncan I., Smith, Paul D., Cook, Simon J.

“…BRAF and MEK1/2 inhibitors are effective in melanoma but resistance inevitably develops. Despite increasing the abundance of pro-apoptotic BIM and BMF, ERK1/2…”
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Auditing the Representation of Female Versus Male Athletes in Sports Science and Sports Medicine Research: Evidence-Based Performance Supplements by Smith, Ella S, McKay, Alannah K A, Kuikman, Megan, Ackerman, Kathryn E, Harris, Rachel, Elliott-Sale, Kirsty J, Stellingwerff, Trent, Burke, Louise M

“…Although sports nutrition guidelines promote evidence-based practice, it is unclear whether women have been adequately included in the underpinning research…”
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Factors influencing the pharmacological management of osteoporosis after fragility fracture: results from the Ontario Osteoporosis Strategy’s fracture clinic screening program by Beaton, D. E., Dyer, S., Jiang, D., Sujic, R., Slater, M., Sale, J. E. M., Bogoch, E. R.

“…Summary Potential mediating factors in the pathway to initiation of osteoporosis treatment following a fragility fracture were evaluated. Patients’ perceived…”
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Carnosine increases insulin-stimulated glucose uptake and reduces methylglyoxal-modified proteins in type-2 diabetic human skeletal muscle cells by Matthews, Joseph J., Turner, Mark D., Santos, Livia, Elliott-Sale, Kirsty J., Sale, Craig

“…Type-2 diabetes (T2D) is characterised by a dysregulation of metabolism, including skeletal muscle insulin resistance, mitochondrial dysfunction, and oxidative…”
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