Search Results - "Saldova, R."

Automated, high-throughput serum glycoprofiling platform by Stöckmann, H, O'Flaherty, R, Adamczyk, B, Saldova, R, Rudd, P M

“…Complex carbohydrates are rapidly becoming excellent biomarker candidates because of their high sensitivity to pathological changes. However, the discovery of…”
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Levels of specific serum N-glycans identify breast cancer patients with higher circulating tumor cell counts by Saldova, R., Reuben, J.M., Abd Hamid, U.M., Rudd, P.M., Cristofanilli, M.

“…Metastatic breast cancer (MBC) is currently an incurable condition that is primarily treated with palliative measures. Isolation of circulating tumor cells…”
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Glycosylation status of serum in inflammatory arthritis in response to anti-TNF treatment by Collins, Emily S, Galligan, Marie C, Saldova, Radka, Adamczyk, Barbara, Abrahams, Jodie L, Campbell, Matthew P, Ng, Chin-Teck, Veale, Douglas J, Murphy, Thomas B, Rudd, Pauline M, Fitzgerald, Oliver

“…Glycosylation is the most common post-translational modification and is altered in disease. The typical glycosylation change in patients with inflammatory…”
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IgG N-glycans as potential biomarkers for determining galactose tolerance in Classical Galactosaemia by Coss, K.P., Byrne, J.C., Coman, D.J., Adamczyk, B., Abrahams, J.L., Saldova, R., Brown, A.Y., Walsh, O., Hendroff, U., Carolan, C., Rudd, P.M., Treacy, E.P.

“…N-glycan processing and assembly defects have been demonstrated in untreated and partially treated patients with Classical Galactosaemia. These defects may…”
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Levels of specific glycans significantly distinguish lymph node-positive from lymph node-negative breast cancer patients by Pierce, Aisling, Saldova, Radka, Abd Hamid, Umi M, Abrahams, Jodie L, McDermott, Enda W, Evoy, Denis, Duffy, Michael J, Rudd, Pauline M

“…One of the most urgent requirements in breast cancer is the development of a blood-based test for early detection and prognosis. Previously published results…”
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PO-368 Epigenetic regulation of glycosylation and the impact on chemoresistance in ovarian and breast cancer by Greville, G, Llop, E, Peracaula Miró, R, McCann, A, Rudd, PM, Saldova, R

“…IntroductionGlycosylation is epigenetically regulated and is a fundamental post-translational modification altered in cancer. These alterations impact on…”
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1150 Altered Glycosylation of Serum Glycoproteins as Tumour Biomarkers – the Case of Prostate-specific Antigen in Prostate Cancer and the Case of Acute-phase Proteins in Pancreatic Adenocarcinoma by Peracaula, R, Sarrats, A, Balmana, M, Llop, E, Barrabés, S, Saldova, R, Comet, J, Figueras, J, Rudd, P.M, de Llorens, R

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Core fucosylation and  2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia by Saldova, R., Fan, Y., Fitzpatrick, J. M., Watson, R. W. G., Rudd, P. M.

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P–340 Novel non-invasive diagnostic options for endometriosis - based on glycome analysis by Kovacs, Z, Adamczyk, B, Reidy, F, McAuliffe, F M, Rudd, P M, Wingfield, M, Glover, L, Saldova, R

“…Abstract Study question Could glycosylation changes on serum and/or urine glycoproteins be suitable biomarkers for the non-invasive diagnosis of endometriosis?…”
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The O‑Glycome of Human Nigrostriatal Tissue and Its Alteration in Parkinson’s Disease by Wilkinson, Hayden, Thomsson, Kristina A, Rebelo, Ana L, Hilliard, Mark, Pandit, Abhay, Rudd, Pauline M, Karlsson, Niclas G, Saldova, Radka

“…O-Glycosylation changes in misfolded proteins are of particular interest in understanding neurodegenerative conditions such as Parkinson’s disease (PD) and…”
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IDF21-0594 Higher C3 complement protein is associated with cardiometabolic phenotype and biochemical health in women with obesity by Killeen, S.L., Byrne, D.F., Geraghty, A.A., Kilbane, M.T., Twomey, P.J., Mckenna, M.J., Yelverton, C.A., Saldova, R., Van Sinderen, D., Cotter, P.D., Murphy, E.F., Mcauliffe, F.

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N-glycans from serum IgG and total serum glycoproteins specific for endometriosis by Kovács, Zsuzsanna, Reidy, Fiona, Glover, Louise, McAuliffe, Fionnuala M., Stockmann, Henning, Kilbane, Mark T., Twomey, Patrick J., Peters, Maire, Saare, Merli, Rudd, Pauline M., Utt, Meeme, Wingfield, Mary, Salumets, Andres, Saldova, Radka

“…Endometriosis is a chronic inflammatory gynaecological disease characterized by the growth of endometrial tissue outside the uterine cavity. There are…”
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Ovarian Cancer is Associated with Changes in Glycosylation in Both Acute-Phase Proteins and IgG by Saldova, Radka, Royle, Louise, Radcliffe, Catherine M, Abd Hamid, Umi M, Evans, Rachel, Arnold, James N, Banks, Rosamonde E, Hutson, Richard, Harvey, David J, Antrobus, Robin, Petrescu, Stefana M, Dwek, Raymond A, Rudd, Pauline M

“…Ovarian cancer is the fourth most common cancer in women in the Western world. In a pilot scale study, we highlight changes in the total serum glycome of…”
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strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression by Abd Hamid, Umi M, Royle, Louise, Saldova, Radka, Radcliffe, Catherine M, Harvey, David J, Storr, Sarah J, Pardo, Maria, Antrobus, Robin, Chapman, Caroline J, Zitzmann, Nicole, Robertson, John F, Dwek, Raymond A, Rudd, Pauline M

“…Aberrant glycosylation on glycoproteins that are either presented on the surface or secreted by cancer cells is a potential source of disease biomarkers and…”
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Higher Inflammation Is Associated with Cardiometabolic Phenotype and Biochemical Health in Women with Obesity by Killeen, Sarah Louise, Byrne, David F, Geraghty, Aisling A, Kilbane, Mark T, Twomey, Patrick J, McKenna, Malachi J, Yelverton, Cara A, Saldova, Radka, Van Sinderen, Douwe, Cotter, Paul D, Murphy, Eileen F, McAuliffe, Fionnuala M

“…Metabolic or inflammatory markers may predict adverse outcomes in women with obesity. We sought to describe metabolic-obesity phenotypes of women using novel…”
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Glycosylation of liver acute-phase proteins in pancreatic cancer and chronic pancreatitis by Sarrats, Ariadna, Saldova, Radka, Pla, Eva, Fort, Esther, Harvey, David J., Struwe, Weston B., de Llorens, Rafael, Rudd, Pauline M., Peracaula, Rosa

“…Purpose: Glycosylation of acute‐phase proteins (APP), which is partially regulated by cytokines, may be distinct in disease and provide useful tumour markers…”
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Automated, high-throughput serum glycoprofiling platformElectronic supplementary information (ESI) available: Method verification. See DOI: 10.1039/c5ib00130gThe software code is available upon request from the authors by Stöckmann, H, O'Flaherty, R, Adamczyk, B, Saldova, R, Rudd, P. M

“…Complex carbohydrates are rapidly becoming excellent biomarker candidates because of their high sensitivity to pathological changes. However, the discovery of…”
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B95 GETTING BETTER: ADVANCES IN COPD THERAPIES: Targeting Nonsense Mutations For Treatment Of Alpha-1 Antitrypsin Deficiency: Implications For Chronic Obstructive Pulmonary Disease by O'Dwyer, C A, McCarthy, C, Saldova, R, Carroll, T P, Bergin, D A, Henry, M, Meleady, P, Keenan, J, Clynes, M, Liberti, D, Wilson, A A, Kotton, D N, Rowe, S M, Rudd, P, Reeves, E P, McElvaney, N G

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B32 REGULATION OF INFLAMMATION AND LUNG INJURY I: Alpha-1 Antitrypsin Undergoes Sialylation Changes In Response To Acute Inflammation, Which Affects The Ability To Bind Il-8 And Modulate Neutrophil Chemotaxis by McCarthy, C, Lacey, N, Franciosi, A, Saldova, R, O'Dwyer, C A, O'Carroll, O M, McElvaney, O J, Bergin, D A, Carroll, T P, Rudd, P M, Reeves, E P, McElvaney, N G

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Changes of Serum Glycans During Sepsis and Acute Pancreatitis by Gornik, Olga, Royle, Louise, Harvey, David J, Radcliffe, Catherine M, Saldova, Radka, Dwek, Raymond A, Rudd, Pauline, Lauc, Gordan

“…Acute inflammatory response is a complex process associated with the production of both pro- and anti-inflammatory mediators. Although it is generally…”
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