Search Results - "Saldanha, Roland"

Evaluation of Human Performance Aiding Live Synthetically Engineered Bacteria in a Gut-on-a-Chip by Nelson, M. Tyler, Coia, Heidi G., Holt, Corey, Greenwood, Eric S., Narayanan, Latha, Robinson, Peter J., Merrill, Elaine A., Litteral, Vaughn, Goodson, Michael S., Saldanha, Roland J., Grogg, Matthew W., Mauzy, Camilla A.

“…Synbiotics are a new class of live therapeutics employing engineered genetic circuits. The rapid adoption of genetic editing tools has catalyzed the expansion…”
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COVID-19 Seroprevalence and Active Infection in an Asymptomatic Population by Breedon, Amy M. E., Saldanha, Roland J., Salisbury, Richard L., Metzger, David E., Werry, Michael P., McPherson, Craig J., Irvin, Adam P., Davis, Christina M., Bogner, Charles A., Braddock, Amber M., Salter, Charles E., Grigsby, Claude C., Hart, Corey R., Pangburn, Heather A.

“…In response to the COVID-19 pandemic, immediate and scalable testing solutions are needed to direct return to full capacity planning in the general public and…”
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Rapid targeted gene disruption in Bacillus anthracis by Saldanha, Roland J, Pemberton, Adin, Shiflett, Patrick, Perutka, Jiri, Whitt, Jacob T, Ellington, Andrew, Lambowitz, Alan M, Kramer, Ryan, Taylor, Deborah, Lamkin, Thomas J

“…Anthrax is a zoonotic disease recognized to affect herbivores since Biblical times and has the widest range of susceptible host species of any known pathogen…”
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Binding of a Group II Intron-encoded Reverse Transcriptase/Maturase to Its High Affinity Intron RNA Binding Site Involves Sequence-specific Recognition and Autoregulates Translation by Singh, Ravindra N., Saldanha, Roland J., D'Souza, Lisa M., Lambowitz, Alan M.

“…Mobile group II introns encode reverse transcriptases that bind specifically to the intron RNAs to promote both intron mobility and RNA splicing (maturase…”
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Automated analysis and classification of infected macrophages using bright-field amplitude contrast data by Adiga, Umesh, Taylor, Debbie, Bell, Brian, Ponomareva, Larissa, Kanzlemar, Stephen, Kramer, Ryan, Saldanha, Roland, Nelson, Sandra, Lamkin, Thomas J

“…This article presents a methodology for acquisition and analysis of bright-field amplitude contrast image data in high-throughput screening (HTS) for the…”
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Engineering a Cortisol Sensing Enteric Probiotic by Litteral, Vaughn, Migliozzi, Rebecca, Metzger, David, McPherson, Craig, Saldanha, Roland

“…Chronic stress can lead to prolonged adrenal gland secretion of cortisol, resulting in human ailments such as anxiety, post-traumatic stress disorder,…”
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Host Cell Transcriptional Tuning with CRISPR/dCas9 to Mitigate the Effects of Toxin Exposure by Metzger, David, Miller, Kennedy, Lyon, Wanda, Migliozzi, Rebecca, Pangburn, Heather A., Saldanha, Roland

“…Anthrax infection is caused byBacillus anthracis, a bacterium that once established within the host releases lethal toxin (LeTx). Anthrax LeTx is internalized…”
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A Genome-Wide Search for Ionizing-Radiation-Responsive Elements in Deinococcus radiodurans Reveals a Regulatory Role for the DNA Gyrase Subunit A Gene's 5' Untranslated Region in the Radiation and Desiccation Response by Villa, Jordan K, Amador, Paul, Janovsky, Justin, Bhuyan, Arijit, Saldanha, Roland, Lamkin, Thomas J, Contreras, Lydia M

“…Tight regulation of gene expression is important for the survival of , a model bacterium of extreme stress resistance. Few studies have examined the use of…”
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Characterization of stable, constitutively expressed, chromosomal green and red fluorescent transcriptional fusions in the select agent bacterium, Francisella tularensis Schu S4 and the surrogate type B live vaccine strain (LVS) by Su, Shengchang, Saldanha, Roland, Pemberton, Adin, Bangar, Hansraj, Kawamoto, Steven A., Aronow, Bruce, Hassett, Daniel J., Lamkin, Thomas J.

“…Here, we constructed stable, constitutively expressed, chromosomal green (GFP) and red fluorescent (RFP) reporters in the genome of the surrogate strain,…”
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Mapping Infected Cell Phenotype by ADIGA, Umesh, BELL, Brian L, PONOMAREVA, Larissa, TAYLOR, Debbie, SALDANHA, Roland, NELSON, Sandra, LAMKIN, Thomas J

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Involvement of Neurospora mitochondrial tyrosyl-tRNA synthetase in RNA splicing. A new method for purifying the protein and characterization of physical and enzymic properties pertinent to splicing by Saldanha, Roland J, Patel, Smita S, Surendran, Rajendran, Lee, James C, Lambowitz, Alan M

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Mapping Infected Cell Phenotype by Adiga, Umesh, Bell, Brian L., Ponomareva, Larissa, Taylor, Debbie, Saldanha, Roland, Nelson, Sandra, Lamkin, Thomas J.

“…Quantitative modeling of the phenotypic changes in the host cell during the bacterial infection makes it possible to explore an empirical relation between the…”
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Construction and characterization of stable, constitutively expressed, chromosomal green and red fluorescent transcriptional fusions in the select agents, Bacillus anthracis, Yersinia pestis, Burkholderia mallei, and Burkholderia pseudomallei by Su, Shengchang, Bangar, Hansraj, Saldanha, Roland, Pemberton, Adin, Aronow, Bruce, Dean, Gary E., Lamkin, Thomas J., Hassett, Daniel J.

“…Here, we constructed stable, chromosomal, constitutively expressed, green and red fluorescent protein (GFP and RFP) as reporters in the select agents, Bacillus…”
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RNA and Protein Catalysis in Group II Intron Splicing and Mobility Reactions Using Purified Components by Saldanha, Roland, Chen, Bing, Wank, Herbert, Matsuura, Manabu, Edwards, Judy, Lambowitz, Alan M

“…Group II introns encode proteins with reverse transcriptase activity. These proteins also promote RNA splicing (maturase activity) and then, with the excised…”
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A bacterial group II intron encoding reverse transcriptase, maturase, and DNA endonuclease activities: biochemical demonstration of maturase activity and insertion of new genetic information within the intron by Matsuura, M, Saldanha, R, Ma, H, Wank, H, Yang, J, Mohr, G, Cavanagh, S, Dunny, G M, Belfort, M, Lambowitz, A M

“…The Lactococcus lactis group II intron Ll.ltrB is similar to mobile yeast mtDNA group II introns, which encode reverse transcriptase, RNA maturase, and DNA…”
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Group I and group II introns by Saldanha, R, Mohr, G, Belfort, M, Lambowitz, A M

“…Group I and group II introns are two types of RNA enzymes, ribozymes, that catalyze their own splicing by different mechanisms. In this review, we summarize…”
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Science and Technology Solutions for Scalable SARS-CoV-2 Testing to Inform Return to Full Capacity Strategy in United States Air Force Workforce Personnel by Hicks, Daniel T, Metzger, David, Stamps, Blake W, Lee, Jae Hwan, Martin, Jennifer A, Salisbury, Richard L, Saldanha, Roland, Hart, Corey R, Grigsby, Claude C, Pangburn, Heather A

“…SARS-CoV-2 has highlighted the requirement for a drastic change in pandemic response. While cases continue to rise, there is an urgent need to deploy sensitive…”
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Analysis of the CYT-18 Protein Binding Site at the Junction of Stacked Helices in a Group I Intron RNA by Quantitative Binding Assays andin vitroSelection by Saldanha, Roland, Ellington, Andrew, Lambowitz, Alan M.

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Analysis of the CYT-18 protein binding site at the junction of stacked helices in a group I intron RNA by quantitative binding assays and in vitro selection by Saldanha, R, Ellington, A, Lambowitz, A.M

“…The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) functions in splicing group I introns by promoting the formation of the…”
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Analysis of the CYT-18 Protein Binding Site at the Junction of Stacked Helices in a Group I Intron RNA by Quantitative Binding Assays and in vitroSelection by Saldanha, Roland, Ellington, Andrew, Lambowitz, Alan M.

“…The Neurospora crassamitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) functions in splicing group I introns by promoting the formation of the…”
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