Search Results - "Saldanha, Joanne"

The Adaptive Mechanisms and Checkpoint Responses to a Stressed DNA Replication Fork by Saldanha, Joanne, Rageul, Julie, Patel, Jinal A, Kim, Hyungjin

“…DNA replication is a tightly controlled process that ensures the faithful duplication of the genome. However, DNA damage arising from both endogenous and…”
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The Roles of TIMELESS in the Suppression of Single-Stranded DNA Gaps and Mutagenesis by Saldanha, Joanne

“…DNA replication is vital to life necessitating efficiency and accuracy; however, DNA replication fork integrity is challenged by genotoxic insults called…”
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Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe by Patel, Jinal A, Zezelic, Camryn, Rageul, Julie, Saldanha, Joanne, Khan, Arafat, Kim, Hyungjin

“…Abstract The structure of DNA replication forks is preserved by TIMELESS (TIM) in the fork protection complex (FPC) to support seamless fork progression. While…”
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The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation by Saldanha, Joanne, Rageul, Julie, Patel, Jinal A, Phi, Amy L, Lo, Natalie, Park, Jennifer J, Kim, Hyungjin

“…TIMELESS (TIM) in the fork protection complex acts as a scaffold of the replisome to prevent its uncoupling and ensure efficient DNA replication fork…”
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A Transcriptomics and Functional Genetics Approach to Identifying Components of the Drosophila Polyamine Transport System by Saldanha, Joanne, Haney, Michael, Landry, Brianne, Figueroa, Natalia, Kalm, Laurence

“…Polyamines are essential growth factors for normal and malignant cells. Cells obtain polyamines via biosynthesis or transport from the extracellular…”
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An engineered, orthogonal auxin analog/ At TIR1(F79G) pairing improves both specificity and efficacy of the auxin degradation system in Caenorhabditis elegans by Hills-Muckey, Kelly, Martinez, Michael A Q, Stec, Natalia, Hebbar, Shilpa, Saldanha, Joanne, Medwig-Kinney, Taylor N, Moore, Frances E Q, Ivanova, Maria, Morao, Ana, Ward, J D, Moss, Eric G, Ercan, Sevinc, Zinovyeva, Anna Y, Matus, David Q, Hammell, Christopher M

“…Abstract The auxin-inducible degradation system in C. elegans allows for spatial and temporal control of protein degradation via heterologous expression of a…”
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An engineered, orthogonal auxin analog/AtTIR1(F79G) pairing improves both specificity and efficacy of the auxin degradation system in Caenorhabditis elegans by Hills-Muckey, Kelly, Martinez, Michael A Q, Stec, Natalia, Hebbar, Shilpa, Saldanha, Joanne, Medwig-Kinney, Taylor N, Moore, Frances E Q, Ivanova, Maria, Morao, Ana, Ward, J D, Moss, Eric G, Ercan, Sevinc, Zinovyeva, Anna Y, Matus, David Q, Hammell, Christopher M

“…Abstract The auxin-inducible degradation system in C. elegans allows for spatial and temporal control of protein degradation via heterologous expression of a…”
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