Search Results - "Saldanha, J W"

The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism by Gregory, L.C., Gaston-Massuet, C., Andoniadou, C.L., Carreno, G., Webb, E.A., Kelberman, D., McCabe, M.J., Panagiotakopoulos, L., Saldanha, J.W., Spoudeas, H.A., Torpiano, J., Rossi, M., Raine, J., Canham, N., Martinez-Barbera, J.P., Dattani, M.T.

“…Summary Introduction The Gli family of zinc finger (GLI) transcription factors mediates the sonic hedgehog signalling pathway (HH) essential for CNS, early…”
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Nifs and Sufs in malaria by Ellis, K. E. S., Clough, B., Saldanha, J. W., Wilson, R. J. M. (Iain)

“…This review assembles data from three bodies of literature (bacterial genetics, plastid biogenesis and parasitology) that seldom have much direct cross‐talk…”
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Parasite plastids: maintenance and functions by Wilson, R. J. M. (Iain), Rangachari, K., Saldanha, J. W., Rickman, L., Buxton, R. S., Eccleston, J. F.

“…genes have emerged only recently and point to the areas of iron homeostasis, [Fe–S] cluster formation and oxidative stress. We present experimental evidence…”
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Structure and activation of muscarinic acetylcholine receptors by Hulme, E C, Lu, Z L, Saldanha, J W, Bee, M S

“…A homology model of the M(1) muscarinic acetylcholine receptor, based on the X-ray structure of bovine rhodopsin, has been used to interpret the results of…”
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SufC hydrolyzes ATP and interacts with SufB from Thermotoga maritima by Rangachari, K., Davis, C.T., Eccleston, J.F., Hirst, E.M.A., Saldanha, J.W., Strath, M., Wilson, R.J.M.(Iain)

“…Genetic experiments in bacteria have shown the suf operon is involved in iron homeostasis and the oxidative stress response. The sufB and sufC genes that…”
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The extracellular regions of PSMA and the transferrin receptor contain an aminopeptidase domain: Implications for drug design by MAHADEVAN, DARUKA, SALDANHA, JOSÉ W.

“…The Aeromonas proteolytica aminopeptidase (AMP), Pseudomonas sp. (RS-16) carboxypeptidase G2 (CPG2), and Streptomyces griseus aminopeptidase (SGAP) are zinc…”
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Seven-transmembrane receptors: crystals clarify by Lu, Zhi-Liang, Saldanha, Jose W, Hulme, Edward C

“…The X-ray structure of the photoreceptor rhodopsin has provided the first atomic-resolution structure of a seven-transmembrane (7-TM) G-protein-coupled…”
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Site-directed Mutagenesis of CC Chemokine Receptor 1 Reveals the Mechanism of Action of UCB 35625, a Small Molecule Chemokine Receptor Antagonist by de Mendonça, Filipa Lopes, da Fonseca, Paula C.A., Phillips, Rhian M., Saldanha, José W., Williams, Timothy J., Pease, James E.

“…The chemokine receptor CCR1 and its principal ligand, CCL3/MIP-1α, have been implicated in the pathology of several inflammatory diseases including rheumatoid…”
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Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling by Withers-Martinez, Chrislaine, Saldanha, José W, Ely, Barry, Hackett, Fiona, O'Connor, Tony, Blackman, Michael J

“…Serine proteases play crucial roles in erythrocyte invasion by merozoites of the malaria parasite. Plasmodium falciparum subtilisin-like protease-1 (PfSUB-1)…”
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A structural model for the glutamate-specific endopeptidase from Streptomyces griseus that explains substrate specificity by Barbosa, João Alexandre R.G., Garratt, Richard C., Saldanha, José W.

“…We present a model for the three-dimensional structure of the glutamate-specific endopeptidase from Streptomyces griseus based on the crystal structures of…”
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Prediction of domain organisation and secondary structure of thyroid peroxidase, a human autoantigen involved in destructive thyroiditis by Banga, J.Paul, Mahadevan, Daruka, Barton, Geoffrey J., Sutton, Brian J., Saldanha, Jose W., Odell, Eddy, McGregor, Alan M.

“…Organ specific autoimmune diseases are relatively common immunological disorders in man which include thyroid autoimmune disease, insulin-dependent diabetes…”
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Antagonist binding in the rat muscarinic receptor A study by docking and X-ray crystallography by Tanczos, Anna C, Palmer, Rex A, Potter, Brian S, Saldanha, José W, Howlin, Brendan J

“…A series of agonists to the rat muscarinic receptor have been docked computationally to the active site of a homology model of rat M1 muscarinic receptor. The…”
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A single backmutation in the human kIV framework of a previously unsuccessfully humanized antibody restores the binding activity and increases the secretion in cos cells by Saldanha, José W, Martin, Andrew C.R, Léger, Olivier J.P

“…Humanization of rodent mAbs by CDR-grafting (also called “reshaping”) is now a standard procedure for reducing immunogenicity and recruiting human effector…”
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A model for the cytoplasmic domain of the influenza A virus M2 channel by analogy to the HIV-1 Vpu protein by Saldanha, José W, Czabotar, Peter E, Hay, Alan J, Taylor, William R

“…A model for the cytoplasmic domain of the M2 proton channel of influenza A virus was formulated based primarily on the cytoplasmic domain of the Vpu protein of…”
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Structural role of extracellular domain 1 of alpha-platelet-derived growth factor (PDGF) receptor for PDGF-AA and PDGF-BB binding by Mahadevan, D, Yu, J C, Saldanha, J W, Thanki, N, McPhie, P, Uren, A, LaRochelle, W J, Heidaran, M A

“…The purpose of this study was to bacterially express, purify, and refold combinations of the extracellular immunoglobulin (Ig)-like domains (2-3, 1-3, and 1-5)…”
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Transmembrane domains 4 and 7 of the M(1) muscarinic acetylcholine receptor are critical for ligand binding and the receptor activation switch by Lu, Z L, Saldanha, J W, Hulme, E C

“…Activation of the muscarinic acetylcholine receptors requires agonist binding followed by a conformational change, but the ligand binding and…”
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Transmembrane Domains 4 and 7 of the M sub(1) Muscarinic Acetylcholine Receptor Are Critical for Ligand Binding and the Receptor Activation Switch by Lu, Z, Saldanha, J W, Hulme, E C

“…Activation of the muscarinic acetylcholine receptors requires agonist binding followed by a conformational change, but the ligand binding and…”
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Crystal and molecular structure of 5-carbamyl-5H-dibenzo[b,f] azepine by Lisgarten, John N., Palmer, Rex A., Saldanha, Jose W.

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A two-component signal transduction system with a PAS domain-containing sensor is required for virulence of Mycobacterium tuberculosis in mice by Rickman, Lisa, Saldanha, José W, Hunt, Debbie M, Hoar, Dominic N, Colston, M.Joseph, Millar, Jonathan B.A, Buxton, Roger S

“…Mycobacterium tuberculosis, the causative organism of tuberculosis, encounters oxidative stress during phagocytosis by the macrophage and following macrophage…”
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Novel features of serine protease active sites and specificity pockets: sequence analysis and modelling studies of glutamate-specific endopeptidases and epidermolytic toxins by Barbosa, J A, Saldanha, J W, Garratt, R C

“…With a view to obtaining a better understanding of the structural determinants of P1 glutamate specificity in glutamate-specific endopeptidases (GSEs), the…”
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