Search Results - "Salazar, Andres M."

Poly-ICLC, a multi-functional immune modulator for treating cancer by Sultan, Hussein, Salazar, Andres M., Celis, Esteban

“…•Poly-ICLC a synthetic dsRNA mimic stimulates both TLR3 and MDA5.•Poly-ICLC is a potent IFN-I and IL-15 inducer through MDA5 stimulation.•Poly-ICLC is a strong…”
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Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk by Mayer-Barber, Katrin D., Andrade, Bruno B., Oland, Sandra D., Amaral, Eduardo P., Barber, Daniel L., Gonzales, Jacqueline, Derrick, Steven C., Shi, Ruiru, Kumar, Nathella Pavan, Wei, Wang, Yuan, Xing, Zhang, Guolong, Cai, Ying, Babu, Subash, Catalfamo, Marta, Salazar, Andres M., Via, Laura E., Barry III, Clifton E., Sher, Alan

“…Active tuberculosis has been linked to excessive type I interferon induction whereas interleukin-1 may have protective effects; here it is shown that…”
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Phase I trial of overlapping long peptides from a tumor self-antigen and poly-ICLC shows rapid induction of integrated immune response in ovarian cancer patients by Sabbatini, Paul, Tsuji, Takemasa, Ferran, Luis, Ritter, Erika, Sedrak, Christine, Tuballes, Kevin, Jungbluth, Achim A, Ritter, Gerd, Aghajanian, Carol, Bell-McGuinn, Katherine, Hensley, Martee L, Konner, Jason, Tew, William, Spriggs, David R, Hoffman, Eric W, Venhaus, Ralph, Pan, Linda, Salazar, Andres M, Diefenbach, Catherine Magid, Old, Lloyd J, Gnjatic, Sacha

“…Long peptides are efficiently presented to both CD4(+) and CD8(+) T cells after intracellular processing by antigen-presenting cells. To investigate the safety…”
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Induction of CD8+ T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma by OKADA, Hideho, KALINSKI, Pawel, ZEH, Herbert, HOLTZMAN, Matthew P, REINHART, Todd A, WHITESIDE, Theresa L, BUTTERFIELD, Lisa H, HAMILTON, Ronald L, POTTER, Douglas M, POLLACK, Ian F, SALAZAR, Andres M, LIEBERMAN, Frank S, UEDA, Ryo, HOJI, Aki, KOHANBASH, Gary, DONEGAN, Teresa E, MINTZ, Arlan H, ENGH, Johnathan A, BARTLETT, David L, BROWN, Charles K

“…Purpose A phase I/II trial was performed to evaluate the safety and immunogenicity of a novel vaccination with α-type 1 polarized dendritic cells (αDC1) loaded…”
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The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice by Sultan, Hussein, Kumai, Takumi, Nagato, Toshihiro, Wu, Juan, Salazar, Andres M., Celis, Esteban

“…Vaccines consisting of synthetic peptides representing cytotoxic T-lymphocyte (CTL) epitopes have long been considered as a simple and cost-effective approach…”
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Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1–4 by Stewart-Jones, Guillaume B. E., Chuang, Gwo-Yu, Xu, Kai, Zhou, Tongqing, Acharya, Priyamvada, Tsybovsky, Yaroslav, Ou, Li, Zhang, Baoshan, Fernandez-Rodriguez, Blanca, Gilardi, Valentina, Silacci-Fregni, Chiara, Beltramello, Martina, Baxa, Ulrich, Druz, Aliaksandr, Kong, Wing-Pui, Thomas, Paul V., Yang, Yongping, Foulds, Kathryn E., Todd, John-Paul, Wei, Hui, Salazar, Andres M., Scorpio, Diana G., Carragher, Bridget, Potter, Clinton S., Corti, Davide, Mascola, John R., Lanzavecchia, Antonio, Kwong, Peter D.

“…Parainfluenza virus types 1–4 (PIV1–4) are highly infectious human pathogens, of which PIV3 is most commonly responsible for severe respiratory illness in…”
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Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans by Caskey, Marina, Lefebvre, François, Filali-Mouhim, Abdelali, Cameron, Mark J, Goulet, Jean-Philippe, Haddad, Elias K, Breton, Gaëlle, Trumpfheller, Christine, Pollak, Sarah, Shimeliovich, Irina, Duque-Alarcon, Angela, Pan, Li, Nelkenbaum, Annette, Salazar, Andres M, Schlesinger, Sarah J, Steinman, Ralph M, Sékaly, Rafick P

“…Adjuvants are critical for the success of vaccines. Agonists of microbial pattern recognition receptors (PRRs) are promising new adjuvant candidates. A…”
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Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus by Sastry, Mallika, Zhang, Baoshan, Chen, Man, Joyce, M Gordon, Kong, Wing-Pui, Chuang, Gwo-Yu, Ko, Kiyoon, Kumar, Azad, Silacci, Chiara, Thom, Michelle, Salazar, Andres M, Corti, Davide, Lanzavecchia, Antonio, Taylor, Geraldine, Mascola, John R, Graham, Barney S, Kwong, Peter D

“…Appropriate adjuvant selection may be essential to optimize the potency and to tailor the immune response of subunit vaccines. To induce protective responses…”
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Poly-ICLC, a TLR3 Agonist, Induces Transient Innate Immune Responses in Patients With Treated HIV-Infection: A Randomized Double-Blinded Placebo Controlled Trial by Saxena, Mansi, Sabado, Rachel L, La Mar, Melissa, Mohri, Hiroshi, Salazar, Andres M, Dong, Hanqing, Correa Da Rosa, Joel, Markowitz, Martin, Bhardwaj, Nina, Miller, Elizabeth

“…Toll-like receptor-3 agonist Poly-ICLC has been known to activate immune cells and induce HIV replication in pre-clinical experiments. In this study we…”
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Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population by Antonelli, Lis R V, Gigliotti Rothfuchs, Antonio, Gonçalves, Ricardo, Roffê, Ester, Cheever, Allen W, Bafica, Andre, Salazar, Andres M, Feng, Carl G, Sher, Alan

“…Type I IFN has been demonstrated to have major regulatory effects on the outcome of bacterial infections. To assess the effects of exogenously induced type I…”
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Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer by Mehrotra, Shikhar, Britten, Carolyn D, Chin, Steve, Garrett-Mayer, Elizabeth, Cloud, Colleen A, Li, Mingli, Scurti, Gina, Salem, Mohamed L, Nelson, Michelle H, Thomas, Melanie B, Paulos, Chrystal M, Salazar, Andres M, Nishimura, Michael I, Rubinstein, Mark P, Li, Zihai, Cole, David J

“…Dendritic cells (DCs) enhance the quality of anti-tumor immune response in patients with cancer. Thus, we posit that DC-based immunotherapy, in conjunction…”
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Long-term morbidities following self-reported mild traumatic brain injury by Vanderploeg, Rodney D., Curtiss, Glenn, Luis, Cheryl A., Salazar, Andres M.

“…The objective of this study was to examine the prevalence of long-term psychiatric, neurologic, and psychosocial morbidities of self-reported mild traumatic…”
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Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non‐human primates by Li, Jessica, Ahmet, Fatma, Sullivan, Lucy C., Brooks, Andrew G., Kent, Stephen J., Rose, Robert, Salazar, Andres M., Reis e Sousa, Caetano, Shortman, Ken, Lahoud, Mireille H., Heath, William R., Caminschi, Irina

“…Targeting antigens to dendritic cell (DC) surface receptors using antibodies has been successfully used to generate strong immune responses and is currently in…”
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Poly-IC enhances the effectiveness of cancer immunotherapy by promoting T cell tumor infiltration by Sultan, Hussein, Wu, Juan, Fesenkova, Valentyna I, Fan, Aaron E, Addis, Diane, Salazar, Andres M, Celis, Esteban

“…BackgroundImmunotherapies, such as immune checkpoint inhibitors and adoptive cell therapies, have revolutionized cancer treatment and resulted in complete and…”
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Designing therapeutic cancer vaccines by mimicking viral infections by Sultan, Hussein, Fesenkova, Valentyna I., Addis, Diane, Fan, Aaron E., Kumai, Takumi, Wu, Juan, Salazar, Andres M., Celis, Esteban

“…The design of efficacious and cost-effective therapeutic vaccines against cancer remains both a research priority and a challenge. For more than a decade, our…”
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Hiltonol Cocktail Kills Lung Cancer Cells by Activating Cancer-Suppressors, PKR/OAS, and Restraining the Tumor Microenvironment by Chang, Shu-Chun, Zhang, Bo-Xiang, Su, Emily Chia-Yu, Wu, Wei-Ciao, Hsieh, Tsung-Han, Salazar, Andres M, Lin, Yen-Kuang, Ding, Jeak Ling

“…NSCLC (non-small cell lung cancer) is a leading cause of cancer-related deaths worldwide. Clinical trials showed that Hiltonol, a stable dsRNA representing an…”
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Profound impairment of adaptive immune responses by alkylating chemotherapy by Litterman, Adam J, Zellmer, David M, Grinnen, Karen L, Hunt, Matthew A, Dudek, Arkadiusz Z, Salazar, Andres M, Ohlfest, John R

“…Overall, cancer vaccines have had a record of failure as an adjuvant therapy for malignancies that are treated with alkylating chemotherapy, and the…”
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Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates by Flynn, Barbara J, Kastenmüller, Kathrin, Wille-Reece, Ulrike, Tomaras, Georgia D, Alam, Munir, Lindsay, Ross W, Salazar, Andres M, Perdiguero, Beatriz, Gomez, Carmen E, Wagner, Ralf, Esteban, Mariano, Park, Chae G, Trumpfheller, Christine, Keler, Tibor, Pantaleo, Giuseppe, Steinman, Ralph M, Seder, Robert

“…Protein vaccines, if rendered immunogenic, would facilitate vaccine development against HIV and other pathogens. We compared in nonhuman primates (NHPs) immune…”
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Full-Length Plasmodium falciparum Circumsporozoite Protein Administered with Long-Chain Poly(I·C) or the Toll-Like Receptor 4 Agonist Glucopyranosyl Lipid Adjuvant-Stable Emulsion Elicits Potent Antibody and CD4+ T Cell Immunity and Protection in Mice by Kastenmüller, Kathrin, Espinosa, Diego A, Trager, Lauren, Stoyanov, Cristina, Salazar, Andres M, Pokalwar, Santosh, Singh, Sanjay, Dutta, Sheetij, Ockenhouse, Christian F, Zavala, Fidel, Seder, Robert A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Type I IFN Induction via Poly-ICLC Protects Mice against Cryptococcosis by Sionov, Edward, Mayer-Barber, Katrin D, Chang, Yun C, Kauffman, Keith D, Eckhaus, Michael A, Salazar, Andres M, Barber, Daniel L, Kwon-Chung, Kyung J

“…Cryptococcus neoformans is the most common cause of fungal meningoencephalitis in AIDS patients. Depletion of CD4 cells, such as occurs during advanced AIDS,…”
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