Pattern of Clinical and Laboratory Presentation of Cerebral Malaria among Children in Nigeria

Pattern of Clinical and Laboratory Presentation of Cerebral Malaria among Children in Nigeria

Cerebral malaria (CM) is the most lethal form of severe malaria with high case fatality rates. Overtime, there is an inherent risk in changing pattern of presentation of CM which, if the diagnosis is missed due to these changing factors, may portend a poor outcome. Variations in the pattern of clini...

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Bibliographic Details
Published in:Journal of global infectious diseases Vol. 16; no. 1; pp. 5 - 12
Main Authors: Jegede, Tolulope O, Oseni, Saheed B, Okeniyi, John A O, Kuti, Bankole Peter, Adegoke, Samuel A, Salau, Qasim A, Bello, Emmanuel Olaseinde, Jegede, Temitope Oyinlola, Kareem, Abiodun John, Oyelami, Oyeku A, Samuel, Ibitoye Bayode, Oluwatuyi, Korede O, Ekogiawe, Foluwakemi T, Obasohan, Stanley E, Abazu, Ikechukwu S, Babalola, Emmanuel O
Format: Journal Article
Language:English
Published: India Medknow Publications and Media Pvt. Ltd 01-01-2024
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects:
Anemia
cerebral malaria
Childrens health
clinical features
coma
Convulsions & seizures
Cross-sectional studies
Diagnosis
Hematology
Hyperglycemia
hyperparasitemia
Infections
Inflammation
Laboratories
Malaria
Microbiology
nigeria
Original
Vector-borne diseases
Nigeria
Malawi
Cerebral malaria
Nigeria
clinical features
coma
hyperparasitemia
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Summary:Cerebral malaria (CM) is the most lethal form of severe malaria with high case fatality rates. Overtime, there is an inherent risk in changing pattern of presentation of CM which, if the diagnosis is missed due to these changing factors, may portend a poor outcome. Variations in the pattern of clinic-laboratory presentations also make generalization difficult. This study was, therefore, set out to report the pattern of clinical and laboratory presentation of CM. This was a cross-sectional study among children aged 6 months to 14 years admitted with a diagnosis of CM as defined by the World Health Organization criteria. A pretested pro forma was filled, and detailed neurological examination and laboratory (biochemical, microbiology, and hematology) investigations were done. <5% was considered statistically significant. Sixty-four children were recruited with a mean age of 34.9 ± 24.9 months and a male-to-female ratio of 1.9:1. There were 87.5% of under-five children. Fever (96.9%) was the major presenting feature closely followed by convulsions (92.2%). Convulsions were mainly generalized (94.9%) and multiple (76.5%). Profound coma (Blantyre coma score of 0) was present in 12.5% of cases, and the leading features on examination were fever (84.4%) and pallor (75.0%). Retinal vessel whitening (48.4%) was the most common funduscopic abnormality. Metabolic acidosis (47.9%), severe anemia (14.1%), hyperglycemia (17.2%), and hypoglycemia (7.8%) were seen among the children. Few (1.6%) had hyperparasitemia and bacteremia (3.2%). Early recognition of the clinical presentation and prompt management may improve the outcome of cerebral malaria.
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content type line 23
ISSN:0974-777X
0974-8245
DOI:10.4103/jgid.jgid_100_23