Search Results - "Salatino, Roberto"

Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma by Walentynowicz, Kacper A., Engelhardt, Dalit, Cristea, Simona, Yadav, Shreya, Onubogu, Ugoma, Salatino, Roberto, Maerken, Melanie, Vincentelli, Cristina, Jhaveri, Aashna, Geisberg, Jacob, McDonald, Thomas O., Michor, Franziska, Janiszewska, Michalina

“…Glioblastoma (GBM) is the most aggressive brain tumor, with a median survival of ∼15 months. Targeted approaches have not been successful in this tumor type…”
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In vivo mRNA display enables large-scale proteomics by next generation sequencing by Oikonomou, Panos, Salatino, Roberto, Tavazoie, Saeed

“…Large-scale proteomic methods are essential for the functional characterization of proteins in their native cellular context. However, proteomics has lagged…”
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TMIC-71. SPATIAL ANALYSIS OF GENETIC HETEROGENEITY AND TUMOR MICROENVIRONMENT INTERACTIONS IN GLIOBLASTOMA by Onubogu, Ugoma, Salatino, Roberto, Szentirmai, Oszkar, Vaubel, Rachael, Janiszewska, Michalina

“…Abstract Genetic variation can be considered a driver of somatic evolution in glioblastoma (GBM); however, the tumor microenvironment (TME) is a key…”
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TMOD-22. MULTIREGION BIOPSIES AND CORRESPONDING NEUROSPHERE CULTURES REVEAL SPATIAL DIVERGENCE IN GLIOBLASTOMA EVOLUTION by Salatino, Roberto, Geisberg, Jacob, Onubogu, Ugoma, Romero-Toledo, Arantxa, Oakes, Banjamin, Szentirmai, Oszkar, McDonald, Thomas, Michor, Franziska, Janiszewska, Michalina

“…Abstract Spatial organization of normal tissues is key for their function, yet the role of distribution of distinct clones of cancer cells in tumor is not…”
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TMIC-84. MULTIREGIONAL ANALYSIS OF GLIOBLASTOMA REVEALS TOPOLOGICAL DIVERGENCE OF CANCER CELLS AND THEIR SURROUNDING MICROENVIRONMENT by Salatino, Roberto, Onubogu, Ugoma, Klemm, Florian, Joyce, Johanna, Szentirmai, Oszkar, Janiszewska, Michalina

“…Abstract Tissue organization plays an important role in tumor development and evolution. Systematic investigation of the differences in the local composition…”
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Abstract PR014: Multiregion biopsies and corresponding neurosphere cultures reveal spatial divergence in glioblastoma evolution by Salatino, Roberto, Onubogu, Ugoma, Oakes, Benjamin, Szentirmai, Oszkar, Janiszewska, Michalina

“…Abstract Spatial organization of normal tissues is key for their function, yet the role of distribution of distinct clones of cancer cells in tumor in not…”
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A Novel Approach to Measure and Model the Interplay Between Multiple Layers of Cellular Heterogeneity in Glioblastoma by Salatino, Roberto M

“…Intratumor heterogeneity has been associated with glioblastoma multiforme (GBM) for a long time1–3. The coexistence of heterogeneous cellular sub-populations…”
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PATH-29. GLIOBLASTOMA TUMOR CLASSIFICATION BASED ON SPATIAL ANALYSIS OF ONCOGENIC AMPLIFICATIONS AND PROTEIN EXPRESSION by Walentynowicz, Kacper, Engelhardt, Dalit, Yadav, Shreya, Onubogu, Ugoma, Salatino, Roberto, Vincentelli, Cristina, McDonald, Thomas, Michor, Franziska, Janiszewska, Michalina

“…Abstract Heterogeneity of glioblastoma (GBM) has been extensively studied in recent years with identification of oncogenic drivers of GBM cellular subtypes…”
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Abstract IA013: Genetic heterogeneity and tumor microenvironment in glioblastoma by Walentynowicz, Kacper A., Engelhardt, Dalit, Yadav, Shreya, Onubogu, Ugoma, Salatino, Roberto, Vincentelli, Cristina, McDonald, Thomas O., Michor, Franziska, Janiszewska, Michalina

“…Abstract Glioblastoma (GBM), the most aggressive brain tumor, remains an unmet medical need. Despite aggressive chemotherapy, radiation and surgery, only 5.6%…”
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Spatial analysis of recurrent glioblastoma reveals perivascular niche organization by Onubogu, Ugoma, Gatenbee, Chandler D, Prabhakaran, Sandhya, Wolfe, Kelsey L, Oakes, Benjamin, Salatino, Roberto, Vaubel, Rachael, Szentirmai, Oszkar, Anderson, Alexander Ra, Janiszewska, Michalina

“…Tumor evolution is driven by genetic variation; however, it is the tumor microenvironment (TME) that provides the selective pressure contributing to evolution…”
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