Search Results - "Salat, D.H."

Imaging small vessel-associated white matter changes in aging by Salat, D.H

“…Highlights • Changes in small vessel sufficiency with aging impact neural health and function. • Variation in even the ‘normal’ vascular range may measurably…”
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White matter pathology isolates the hippocampal formation in Alzheimer's disease by Salat, D.H, Tuch, D.S, van der Kouwe, A.J.W, Greve, D.N, Pappu, V, Lee, S.Y, Hevelone, N.D, Zaleta, A.K, Growdon, J.H, Corkin, S, Fischl, B, Rosas, H.D

“…Abstract Prior work has demonstrated that the memory dysfunction of Alzheimer's disease (AD) is accompanied by marked cortical pathology in medial temporal…”
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Tract-based analysis of white matter degeneration in Alzheimer’s disease by Lee, S.-H, Coutu, J.-P, Wilkens, P, Yendiki, A, Rosas, H.D, Salat, D.H

“…Highlights • Automated tractography tool TRACULA was used to measure the integrity of WM. • Deterioration of fibers is greatest in tracts known to be connected…”
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Correlations between MRI white matter lesion location and executive function and episodic memory by SMITH, E. E, SALAT, D. H, GREENBERG, S. M, JENG, J, MCCREARY, C. R, FISCHL, B, SCHMAHMANN, J. D, DICKERSON, B. C, VISWANATHAN, A, ALBERT, M. S, BLACKER, D

“…MRI white matter hyperintensity (WMH) volume is associated with cognitive impairment. We hypothesized that specific loci of WMH would correlate with cognition…”
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Age-associated alterations in cortical gray and white matter signal intensity and gray to white matter contrast by Salat, D.H., Lee, S.Y., van der Kouwe, A.J., Greve, D.N., Fischl, B., Rosas, H.D.

“…Prior studies have focused on patterns of brain atrophy with aging and age-associated cognitive decline. It is possible that changes in neural tissue…”
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Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths by Dickerson, B.C., Fenstermacher, E., Salat, D.H., Wolk, D.A., Maguire, R.P., Desikan, R., Pacheco, J., Quinn, B.T., Van der Kouwe, A., Greve, D.N., Blacker, D., Albert, M.S., Killiany, R.J., Fischl, B.

“…In normal humans, relationships between cognitive test performance and cortical structure have received little study, in part, because of the paucity of tools…”
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Age-related alterations in white matter microstructure measured by diffusion tensor imaging by Salat, D.H., Tuch, D.S., Greve, D.N., van der Kouwe, A.J.W., Hevelone, N.D., Zaleta, A.K., Rosen, B.R., Fischl, B., Corkin, S., Rosas, H. Diana, Dale, A.M.

“…Cerebral white matter (WM) undergoes various degenerative changes with normal aging, including decreases in myelin density and alterations in myelin structure…”
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Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease by Rosas, H.D., Wilkens, P., Salat, D.H., Mercaldo, N.D., Vangel, M., Yendiki, A.Y., Hersch, S.M.

“…Although much prior work has focused on the basal ganglia and cortical pathology that defines Huntington's disease (HD), recent studies have also begun to…”
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SKA2 methylation is associated with decreased prefrontal cortical thickness and greater PTSD severity among trauma-exposed veterans by Sadeh, N, Spielberg, J M, Logue, M W, Wolf, E J, Smith, A K, Lusk, J, Hayes, J P, Sperbeck, E, Milberg, W P, McGlinchey, R E, Salat, D H, Carter, W C, Stone, A, Schichman, S A, Humphries, D E, Miller, M W

“…Methylation of the SKA2 (spindle and kinetochore-associated complex subunit 2) gene has recently been identified as a promising biomarker of suicide risk…”
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Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD by DICKERSON, B. C, SALAT, D. H, ALBERT, M. S, SPERLING, R. A, GREVE, D. N, CHUA, E. F, RAND-GIOVANNETTI, E, RENTZ, D. M, BERTRAM, L, MULLIN, K, TANZI, R. E, BLACKER, D

“…To use fMRI to investigate whether hippocampal and entorhinal activation during learning is altered in the earliest phase of mild cognitive impairment (MCI)…”
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Tapping linked to function and structure in premanifest and symptomatic Huntington disease by BECHTEL, N, SCAHILL, R. I, SALAT, D. H, DURR, A, LEAVITT, B. R, ROOS, R. A. C, LANDWEHRMEYER, G. B, LANGBEHN, D. R, STOUT, J. C, TABRIZI, S. J, REILMANN, R, ROSAS, H. D, ACHARYA, T, VAN DEN BOGAARD, S. J. A, JAUFFRET, C, SAY, M. J, STURROCK, A, JOHNSON, H, ONORATO, C. E

“…Motor signs are functionally disabling features of Huntington disease. Characteristic motor signs define disease manifestation. Their severity and onset are…”
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Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's disease by Salat, D.H., Chen, J.J., van der Kouwe, A.J., Greve, D.N., Fischl, B., Rosas, H.D.

“…Recent studies have demonstrated alterations in cortical gray to white matter tissue contrast with nondemented aging and in individuals with Alzheimer's…”
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SKA2 methylation predicts reduced cortical thickness in prefrontal cortex by Sadeh, N, Spielberg, J M, Logue, M W, Wolf, E J, Smith, A K, Lusk, J, Hayes, J P, Sperbeck, E, Milberg, W P, McGlinchey, R E, Salat, D H, Carter, W C, Stone, A, Schichman, S A, Humphries, D E, Miller, M W

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Neuroimaging H.M.: A 10-year follow-up examination by Salat, D.H., van der Kouwe, A.J.W., Tuch, D.S., Quinn, B.T., Fischl, B., Dale, A.M., Corkin, S.

“…In 1997, Corkin et al. described the anatomical boundaries of the amnesic patient H.M.'s surgical resection, based on a comprehensive analysis of magnetic…”
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The Effects of Androgen Deprivation on Prefrontal White Matter by Roalf, D.R., Berlow, Y.A., Lebow, M.R., Young, L.A., Salat, D.H., Janowsky, J.S.

“…Androgen deprivation therapy (ADT) is commonly used to delay the progression of prostate cancer (PC), but neurocognitive side effects such as memory loss are…”
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Classical Eyeblink Conditioning Performance is Associated with Variations in Regional Brain Volumes and Cortical Thickness by McGlinchey, R.E., Fortier, C.B., Leritz, E.C., Salat, D.H., Maksimovskiy, A.L., Venne, J.R., Williams, V., Chapman, C.E., Milberg, W.P.

“…Learning deficits in specific tasks using the eyeblink conditioning paradigm (e.g., discrimination training versus reversal training; production of CRs during…”
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Sex differences in prefrontal volume with aging and Alzheimer’s disease by Salat, D.H, Stangl, P.A, Kaye, J.A, Janowsky, J.S

“…We used volumetric magnetic resonance imaging to examine sex differences in prefrontal tissue volumes of healthy aged and patients with Alzheimer’s disease…”
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