Search Results - "Salamone, Isabella"
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CBX2 is required to stabilize the testis pathway by repressing Wnt signaling
Published in PLoS genetics (22-05-2019)“…XX and XY fetal gonads are initially bipotential, poised between the ovary and testis fate. Multiple lines of evidence suggest that commitment to testis fate…”
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2
Sex reversal following deletion of a single distal enhancer of Sox9
Published in Science (American Association for the Advancement of Science) (29-06-2018)“…Cell fate decisions require appropriate regulation of key genes. , a direct target of SRY, is pivotal in mammalian sex determination. In vivo high-throughput…”
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3
Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms
Published in The Journal of clinical investigation (15-03-2022)“…Glucocorticoid steroids are commonly prescribed for many inflammatory conditions, but chronic daily use produces adverse effects, including muscle wasting and…”
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4
Moderate exercise improves function and increases adiponectin in the mdx mouse model of muscular dystrophy
Published in Scientific reports (08-04-2019)“…The loss of dystrophin produces a mechanically fragile sarcolemma, causing muscle membrane disruption and muscle loss. The degree to which exercise alters…”
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Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination
Published in Developmental biology (15-02-2019)“…Cis-regulatory elements are critical for the precise spatiotemporal regulation of genes during development. However, identifying functional regulatory sites…”
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Mechanisms and Clinical Applications of Glucocorticoid Steroids in Muscular Dystrophy
Published in Journal of neuromuscular diseases (01-01-2021)“…Glucocorticoid steroids are widely used as immunomodulatory agents in acute and chronic conditions. Glucocorticoid steroids such as prednisone and deflazacort…”
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Intermittent Glucocorticoid Dosing Improves Muscle Repair and Function in Mice with Limb-Girdle Muscular Dystrophy
Published in The American journal of pathology (01-11-2017)“…The muscular dystrophies are genetically diverse. Shared pathological features among muscular dystrophies include breakdown, or loss of muscle, and…”
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Anti-latent TGFβ binding protein 4 antibody improves muscle function and reduces muscle fibrosis in muscular dystrophy
Published in Science translational medicine (08-09-2021)“…Duchenne muscular dystrophy, like other muscular dystrophies, is a progressive disorder hallmarked by muscle degeneration, inflammation, and fibrosis. Latent…”
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Hypertrophic Cardiomyopathy Secondary to RAF1 Cysteine-Rich Domain Variants
Published in Circulation. Genomic and precision medicine (01-12-2023)Get full text
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10
Sexually Dimorphic Mechanisms of Skeletal Muscle Adaptation
Published 01-01-2022“…Skeletal muscle is a highly sexually dimorphic tissue, with males and females exhibiting differences in muscle size, gene transcription, and metabolism. This…”
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Dissertation -
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Abstract 439: Trajectory Analysis of Left Ventricular Dimensions From Biobank Data Uncovers Novel Genetic Associations
Published in Circulation research (31-07-2020)“…Abstract only Background: Approximately 6 million adults in the United States have heart failure. The progression of heart failure is variable arising from…”
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Journal Article -
12
Sex reversal following deletion of a single far upstream enhancer of Sox9
Published in Science (American Association for the Advancement of Science) (14-06-2018)“…Cell fate decisions require appropriate regulation of key genes. Sox9 , a direct target of SRY, is pivotal in mammalian sex determination. In vivo…”
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Journal Article -
13
Bioclimatic, ecological, and phenotypic intermediacy and high genetic admixture in a natural hybrid of octoploid strawberries
Published in American journal of botany (01-05-2013)“…• Premise of the Study: Hybrid zones provide “natural laboratories” for understanding the processes of selection, reinforcement, and speciation. We sought to…”
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