Search Results - "Salameh, Moh'd A."

Purification and Characterization of Two Highly Thermophilic Alkaline Lipases from Thermosyntropha lipolytica by Salameh, Moh'd A, Wiegel, Juergen

“…Two thermostable lipases were isolated and characterized from Thermosyntropha lipolytica DSM 11003, an anaerobic, thermophilic, alkali-tolerant bacterium which…”
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Biochemical and structural insights into mesotrypsin: an unusual human trypsin by Salameh, Moh'd A, Radisky, Evette S

“…Thirty five years ago mesotrypsin was first isolated from the human pancreas. It was described as a minor trypsin isoform with the remarkable property of near…”
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Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin by Salameh, Moh'd A., Soares, Alexei S., Hockla, Alexandra, Radisky, Evette S.

“…Human mesotrypsin is an isoform of trypsin that displays unusual resistance to polypeptide trypsin inhibitors and has been observed to cleave several such…”
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Effects of Detergents on Activity, Thermostability and Aggregation of Two Alkalithermophilic Lipases from Thermosyntropha lipolytica by Salameh, Moh'd A, Wiegel, Juergen

“…Thermosyntropha lipolytica DSM 11003, an anaerobic thermophilic lipolytic bacterium, produces the two alkalithermophilic lipases, LipA and LipB. Among all…”
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The Amyloid Precursor Protein/Protease Nexin 2 Kunitz Inhibitor Domain Is a Highly Specific Substrate of Mesotrypsin by Salameh, Moh'd A., Robinson, Jessica L., Navaneetham, Duraiswamy, Sinha, Dipali, Madden, Benjamin J., Walsh, Peter N., Radisky, Evette S.

“…The amyloid precursor protein (APP) is a ubiquitously expressed transmembrane adhesion protein and the progenitor of amyloid-β peptides. The major splice…”
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Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids by Szabó, András, Salameh, Moh'd A, Ludwig, Maren, Radisky, Evette S, Sahin-Tóth, Miklós

“…Human cationic and anionic trypsins are sulfated on Tyr154, a residue which helps to shape the prime side substrate-binding subsites. Here, we used phage…”
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PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancer by Hockla, Alexandra, Miller, Erin, Salameh, Moh'd A, Copland, John A, Radisky, Derek C, Radisky, Evette S

“…PRSS3/mesotrypsin is an atypical isoform of trypsin that has been associated with breast, lung, and pancreatic cancer cell malignancy. In analyses of open…”
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Determinants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with Mesotrypsin by Salameh, Moh'd A., Soares, Alexei S., Navaneetham, Duraiswamy, Sinha, Dipali, Walsh, Peter N., Radisky, Evette S.

“…An important functional property of protein protease inhibitors is their stability to proteolysis. Mesotrypsin is a human trypsin that has been implicated in…”
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Presence versus absence of hydrogen bond donor Tyr‐39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors by Salameh, Moh'd A., Soares, Alexei S., Alloy, Alexandre, Radisky, Evette S.

“…Mesotrypsin displays unusual resistance to inhibition by polypeptide trypsin inhibitors and cleaves some such inhibitors as substrates, despite a high degree…”
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Synthesis of fatty acid esters and diacylglycerols at elevated temperatures by alkalithermophilic lipases from Thermosyntropha lipolytica by Salameh, Moh’d A., Wiegel, Juergen

“…LipA and LipB of Thermosyntropha lipolytica DSM 11003 as previously published are the most alkalithermophilic (pH opt 25°C  = 9.4–9.6, T opt  = 96°C) and…”
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The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity by Salameh, Moh'd A, Soares, Alexei S, Hockla, Alexandra, Radisky, Derek C, Radisky, Evette S

“…PRSS3/mesotrypsin is an atypical isoform of trypsin, the up-regulation of which has been implicated in promoting tumour progression. Mesotrypsin inhibitors…”
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